Heartland banyangvirus

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Heartland banyangvirus
Virus classification Red Pencil Icon.png
(unranked): Virus
Realm: Riboviria
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Phenuiviridae
Genus: Banyangvirus
Species:
Heartland banyangvirus
Synonyms [1]

Heartland virus

Heartland banyangvirus, sometimes called Heartland virus (HRTV), is a tick-borne phlebovirus of the Bhanja virus serocomplex discovered in 2009. The lone star tick transmits the virus to people when feeding on blood. As of 2017, only five Midwestern United States have reported 20 human infections, namely Arkansas, Indiana, Missouri, Oklahoma, and Tennessee; symptoms resemble those of two other tick-borne infections ehrlichiosis and anaplasmosis. The reservoir host is unknown, but deer, raccoon, coyotes, and moose in 13 different states have antibody titers against the virus.

Contents

History

The Heartland virus (HRTV) was discovered in 2009 in northwestern Missouri by Dr. Scott Folk of Heartland Regional Medical Center in St. Joseph, Missouri. [2] The virus was first proven to infect humans in June 2009 when two farmers, living 60 miles (97 km) apart, presented with fever, fatigue, diarrhea, thrombocytopenia, and leukopenia. [3] The Lone Star Tick transmits the virus to people when feeding on blood.

Classification

The Heartland virus is part of the Bunyavirales order of viruses which contain 3 segments of −ssRNA. The genus of the virus is Phlebovirus and the species is the Heartland virus. [4] The SFTS virus from China, discovered in 2011, is a related species causing a similar disease.[ citation needed ]

Transmission

In 2013, researchers from the CDC and Missouri Western State University first isolated the Heartland virus (HRTV) from the Lone Star Tick ( Amblyomma americanum ). [4] [5] As of 2013 work continued to identify the reservoir host, [4] as HRTV has not been isolated from any wild or domestic animals though many white-tailed deer and raccoon from northwestern Missouri had antibodies to HRTV, suggesting that they may be hosts.

In a 2015 retrospective study using convenience samples of different wild animal sera deer, raccoon, coyotes, and moose had antibodies against HRTV. They lived in thirteen states: Florida, Georgia, Illinois, Indiana, Kansas, Kentucky, Missouri, North Carolina, Tennessee, Texas, but also New Hampshire, Maine and Vermont. The infections could have occurred as early as 2003, based on the estimated ages of affected deer. Since the Lone Star tick does not occur in northern New England it is assumed that a second type of tick can carry HRTV. [6]

Infection

Signs and symptoms

Signs and symptoms include fever in excess of 100.4 °F (38 °C), lethargy (weakness), headaches, muscle pain (myalgia), loss of appetite, nausea, diarrhea, weight loss, joint pain (arthralgia), low white blood cell count (leukopenia) and easy bruising due to a low platelet count (thrombocytopenia). Elevated liver transaminases may also be present. [7]

Risk factors

All known human cases have been reported from five U.S. states: Arkansas, Indiana, Missouri, Oklahoma, and Tennessee. Most people infected were spending time outdoors in regions where ticks are endemic. Most infections are diagnosed between May and September. People usually report having been bitten by a tick within two weeks prior to seeking health care.[ citation needed ]

Diagnosis

Diagnosis is through the elimination of other causes of infectious diseases with related symptoms like ehrlichiosis and anaplasmosis or if the patient fails to respond to treatment with the antibiotic doxycycline. RT-PCR may then be used to detect viral ssRNA in the blood. Antibody titers against the virus may also be used to indicate infection with the Heartland virus. [8]

Treatment

Treatment is non-specific. Antibiotics are not useful against viruses. Intravenous fluid administration and medications for the relief of pain are currently the best options. [9]

Prevention

When planning to spend time outdoors in areas where the virus is known or suspected to be harbored by ticks, it is recommended that one cover the body completely with long sleeves and pants, and to avoid bushy and wooded areas. Although ticks are not consistently repelled by DEET-containing repellents, insect repellents should still be applied to one's body and gear. It is recommended that one perform thorough tick checks after being outside, and to remove any tick immediately. If a tick is found, one should remove the tick by the head, preferably with a pair of fine-tipped tweezers. Squeezing the abdomen of a tick while it is attached can force viruses and bacteria into the wound, increasing the chance of infection. Crushing an unattached tick will also release bacteria and viruses from its abdomen, which may then be able to enter a wound or burrow through the skin.[ citation needed ]

Human Cases

More than 20 human infections have been reported in the United States. [10]

Heartland virus cases
YearLocationDeathsCases
2009Northwestern Missouri02
2012–2013 [8] Missouri, Tennessee [11] 16
2014Missouri, [12] Oklahoma [13] 13
2017Northwestern Arkansas, [10] Indiana [14] 03

Related Research Articles

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Arbovirus Virus transmitted by arthropod vectors

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<i>Bunyavirales</i> Order of negative-sense single-stranded RNA viruses

Bunyavirales is an order of negative-sense single-stranded RNA viruses. It is the only order in the class Ellioviricetes. It was formerly known as Bunyaviridae family of viruses. The name Bunyavirales derives from Bunyamwera, where the original type species Bunyamwera orthobunyavirus was first discovered. Ellioviricetes is named in honor of late virologist Richard M. Elliott for his early work on bunyaviruses.

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Anaplasmosis is a disease caused by a rickettsial parasite of ruminants, Anaplasma spp and is therefore related to rickettsial disease. The microorganisms are Gram-negative, and infect red blood cells. They are transmitted by natural means through a number of haematophagous species of ticks. The Ixodes tick that commonly transmits Lyme disease also spreads anaplasmosis.

Ehrlichiosis is a tick-borne bacterial infection, caused by bacteria of the family Anaplasmataceae, genera Ehrlichia and Anaplasma. These obligate intracellular bacteria infect and kill white blood cells.

<i>Amblyomma americanum</i> species of arachnid

Amblyomma americanum, also known as the lone star tick, the northeastern water tick, or the turkey tick, is a type of tick indigenous to much of the eastern United States and Mexico, that bites painlessly and commonly goes unnoticed, remaining attached to its host for as long as seven days until it is fully engorged with blood. It is a member of the phylum Arthropoda, class Arachnida. The adult lone star tick is sexually dimorphic, named for a silvery-white, star-shaped spot or "lone star" present near the center of the posterior portion of the adult female shield (scutum); adult males conversely have varied white streaks or spots around the margins of their shields.

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Human granulocytic anaplasmosis human disease

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Human monocytotropic ehrlichiosis human disease

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Ehrlichiosis ewingii infection is an infectious disease caused by an intracellular bacteria, Ehrlichia ewingii. The infection is transmitted to humans by the tick, Amblyomma americanum. This tick can also transmit Ehrlichia chaffeensis, the bacteria that causes human monocytic ehrlichiosis (HME).

Huaiyangshan banyangvirus, formerly SFTS virus, is a tick-borne Banyangvirus in the order Bunyavirales. It appears to be more closely related to the Uukuniemi virus serogroup than to the Sandfly fever group. It is a member of the Bhanja virus serocomplex.

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Batai virus (BATV) is a RNA virus belonging to order Bunyavirales, genus Orthobunyavirus.

Bourbon virus species of virus

Bourbon virus is an RNA virus in the genus Thogotovirus of the family Orthomyxoviridae, which is similar to Dhori virus and Batken virus. It was first identified in 2014 in a man from Bourbon County, Kansas, United States, who died after being bitten by ticks. The case is the eighth report of human disease associated with a thogotovirus globally, and the first in the Western hemisphere. As of May 2015, a case was discovered in Stillwater, Oklahoma and relatively little is known about the virus. No specific treatment or vaccine is available. The virus is suspected to be transmitted by ticks or insects, and avoidance of bites is recommended to reduce risk of infection. In June 2017 a 58-year-old female Missouri State Park employee died from an infection of the Bourbon virus after it had been misdiagnosed for a significant period of time.

References

  1. Maes, Piet; Kuhn, Jens H. (31 August 2018). "Expansion of the order Bunyavirales" (docx). International Committee on Taxonomy of Viruses (ICTV). Retrieved 20 December 2019. Heartland banyangvirus: derived from Heartland virus (and genus Banyangvirus)
  2. Knox, Richard. "Mysterious New 'Heartland Virus' Discovered in Missouri". Shots: NPR's Health Blog. NPR. Retrieved 2012-08-30.
  3. Grady, Denise (2012-09-03). "New Virus Tied to Ticks Poses Puzzle for Doctors". New York Times. Retrieved 2012-09-07.
  4. 1 2 3 Schnirring, Lisa (2013-07-22). "Researchers trace novel Heartland virus to Missouri ticks". CIDRAP. Retrieved 2013-07-23.
  5. Harry M. Savage; Marvin S. Godsey Jr.; Amy Lambert; Nickolas A. Panella; Kristen L. Burkhalter; Jessica R. Harmon; R. Ryan Lash; David C. Ashley; William L. Nicholson (22 July 2013). "First Detection of Heartland Virus (Bunyaviridae: Phlebovirus) from Field Collected Arthropods". Am J Trop Med Hyg. 89 (3): 445–452. doi:10.4269/ajtmh.13-0209. PMC   3771279 . PMID   23878186.
  6. Riemersma KK, Komar N. Heartland Virus Neutralizing Antibodies in Vertebrate Wildlife, United States, 2009–2014. Emerg Infect Dis. 2015 Oct;21(10):1830–3. doi : 10.3201/eid2110.150380
  7. Laura K. McMullan; Scott M. Folk; Aubree J. Kelly; Adam MacNeil; Cynthia S. Goldsmith; Maureen G. Metcalfe; Brigid C. Batten; César G. Albariño; Sherif R. Zaki; Pierre E. Rollin; William L. Nicholson; Stuart T. Nichol (2012-08-30). "A New Phlebovirus Associated with Severe Febrile Illness in Missouri". New England Journal of Medicine. 367 (9): 834–841. doi:10.1056/NEJMoa1203378. PMID   22931317.
  8. 1 2 Pastula, DM; Turabelidze, G; Yates, KF; Jones, TF; Lambert, AJ; Panella, AJ; Kosoy, OI; Velez, JO; Fisher, M; Staples, E (Mar 2014). "Notes from the field: Heartland virus disease - United States, 2012–2013". MMWR Morb Mortal Wkly Rep. 63 (12): 270–1. PMC   5779346 . PMID   24670929.
  9. CDC Media relations CDC Reports More Cases of Heartland Virus Disease CDC press release, 27 March 2014
  10. 1 2 "Case of Heartland virus found in Arkansas resident". Arkansas Department of Health. July 7, 2017. Retrieved July 7, 2017.
  11. Muehlenbachs A, Fata CR, Lambert AJ, Paddock CD, Velez JO, Blau DM, Staples JE, Karlekar MB, Bhatnagar J, Nasci RS, Zaki SR.Heartland Virus–Associated Death in Tennessee Clin Infect Dis. 2014 Sep 15;59(6):845–50. doi : 10.1093/cid/ciu434
  12. TEDDYE SNELL Taking up arms against Heartland disease, Tahlequah Daily Press, June 18, 2014
  13. Associated Press Rare Heartland virus kills man in Oklahoma CBS News, May 28, 2014
  14. Indiana State Department of Health two cases of Heartland virus confirmed in Indiana, 7/11/2017