Joomyeong Kim

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Joomyeong Kim
Joomyeong Kim.jpg
Professor Joomyeong Kim
Born
Joomyeong Kim
NationalityAmerican / South Korean
Education LSU Medical Center at New Orleans, LA (Ph. D.)
Seoul National University (M.S., B.S.)
Alma mater LSU Medical Center at New Orleans, LA (Ph. D., 1995)
Scientific career
Fields Genomic imprinting; Epigenetics
Institutions Oak Ridge National Laboratory
Lawrence Livermore National Laboratory
Louisiana State University

Joomyeong Kim is a Russell Thompson, Jr. Family Professor of Biology at Louisiana State University. His research interests include genomic imprinting and epigenetics. Dr. Kim's laboratory is mainly involved in understanding the functions and regulatory mechanisms governing genes subject to genomic imprinting. [1] Having previously characterized an imprinted domain located on proximal mouse chromosome 7/ human chromosome 19q13.4, his laboratory currently focuses on understanding regulatory mechanisms directing the mono-allelic expression of the seven imprinted genes in the cluster: Peg3, Usp29, Zfp264, APeg3 (paternally expressed) and Zim1, Zim2, Zim3 (maternally expressed). [2] [3] [4] [5] [6] [7] [8] As a second project direction, his lab studies the function of the dominant gene in the cluster, Peg3, as a transcriptional regulator. [9] [10] [11] [12] Past projects in the Kim lab have included studying the epigenetic instability of imprinted genes during tumorigenesis, [13] [14] [15] potential roles of AEBP2 as a PRC2 targeting protein and in neural crest cell development, [16] [17] [18] as well as the DNA methylation of mouse and human retrotransposons. [19] [20]

Contents


Education

Selected publications

References

  1. "Joomyeong Kim" . Retrieved Nov 15, 2017.
  2. Kim J, Ekram MB, Kim H, Faisal M, Frey WD, Huang JM, Tran K, Kim MM, Yu S (2012). "Imprinting control region (ICR) of the Peg3 domain". Hum Mol Genet. 21 (12): 2677–87. doi:10.1093/hmg/dds092. PMC   3363340 . PMID   22394678.
  3. Thiaville MM, Kim H, Frey WD, Kim J (2013). "Identification of an evolutionarily conserved cis-regulatory element controlling the Peg3 imprinted domain". PLOS ONE. 8 (9): e75417. Bibcode:2013PLoSO...875417T. doi: 10.1371/journal.pone.0075417 . PMC   3769284 . PMID   24040411.
  4. Kim J, Ye A (2016). "Phylogenetic and Epigenetic Footprinting of the Putative Enhancers of the Peg3 Domain". PLOS ONE. 11 (4): e0154216. Bibcode:2016PLoSO..1154216K. doi: 10.1371/journal.pone.0154216 . PMC   4841594 . PMID   27104590.
  5. Perera BP, Kim J (2016). "Alternative promoters of Peg3 with maternal specificity". Sci Rep. 6: 24438. Bibcode:2016NatSR...624438P. doi:10.1038/srep24438. PMC   4830991 . PMID   27075691.
  6. He H, Perera BP, Ye A, Kim J (2016). "Parental and sexual conflicts over the Peg3 imprinted domain". Sci Rep. 6: 38136. Bibcode:2016NatSR...638136H. doi:10.1038/srep38136. PMC   128876 . PMID   27901122.
  7. He H, Ye A, Perera BP, Kim J (2017). "YY1's role in the Peg3 imprinted domain". Sci Rep. 7 (1): 6427. Bibcode:2017NatSR...7.6427H. doi:10.1038/s41598-017-06817-5. PMC   5526879 . PMID   28743993.
  8. Bretz CL, Kim J (2017). "Transcription-driven DNA methylation setting on the mouse Peg3 locus". Epigenetics. Sep 19 [Epub ahead of print] (11): 945–952. doi:10.1080/15592294.2017.1377869. PMC   5788428 . PMID   28925797.
  9. Ye A, He H, Kim J (2014). "Paternally expressed Peg3 controls maternally expressed Zim1 as a trans factor". PLOS ONE. 9 (9): e108596. Bibcode:2014PLoSO...9j8596Y. doi: 10.1371/journal.pone.0108596 . PMC   4180786 . PMID   25265264.
  10. Lee S, Ye A, Kim J (2015). "DNA-Binding Motif of the Imprinted Transcription Factor PEG3". PLOS ONE. 10 (12): e0145531. Bibcode:2015PLoSO..1045531L. doi: 10.1371/journal.pone.0145531 . PMC   4686966 . PMID   26692216.
  11. Ye A, He H, Kim J (2016). "PEG3 binds to H19-ICR as a transcriptional repressor". Epigenetics. 11 (12): 889–900. doi:10.1080/15592294.2016.1255385. PMC   5193492 . PMID   27824289.
  12. Ye A, He H, Kim J (2017). "PEG3 control on the mammalian MSL complex". PLOS ONE. 12 (6): e0178363. Bibcode:2017PLoSO..1278363Y. doi: 10.1371/journal.pone.0178363 . PMC   5469463 . PMID   28609438.
  13. Kim J, Bretz CL, Lee S (2015). "Epigenetic instability of imprinted genes in human cancers". Nucleic Acids Res. 43 (22): 10689–99. doi:10.1093/nar/gkv867. PMC   4678850 . PMID   26338779.
  14. Bretz CL, Langohr IM, Lee S, Kim J (2015). "Epigenetic instability at imprinting control regions in a Kras(G12D)-induced T-cell neoplasm". Epigenetics. 10 (12): 1111–201. doi:10.1080/15592294.2015.1110672. PMC   4844204 . PMID   26507119.
  15. Bretz CL, Langohr IM, Kim J (2017). "Epigenetic response of imprinted domains during carcinogenesis". Clin Epigenetics. 9: 90. doi: 10.1186/s13148-017-0393-8 . PMC   5572065 . PMID   28855972.
  16. Kim H, Kang K, Kim J (2009). "AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2". Nucleic Acids Res. 37 (9): 2940–50. doi:10.1093/nar/gkp149. PMC   2685092 . PMID   19293275.
  17. Kim H, Kang K, Ekram MB, Roh TY, Kim J (2011). "Aebp2 as an epigenetic regulator for neural crest cells". PLOS ONE. 6 (9): e25174. Bibcode:2011PLoSO...625174K. doi: 10.1371/journal.pone.0025174 . PMC   3176318 . PMID   21949878.
  18. Kim H, Ekram MB, Bakshi A, Kim J (2015). "AEBP2 as a transcriptional activator and its role in cell migration". Genomics. 105 (2): 108–15. doi:10.1016/j.ygeno.2014.11.007. PMC   4314425 . PMID   25451679.
  19. Bakshi A, Kim J (2014). "Retrotransposon-based profiling of mammalian epigenomes: DNA methylation of IAP LTRs in embryonic stem, somatic and cancer cells". Genomics. 104 (6): 538–44. doi:10.1016/j.ygeno.2014.09.009. PMC   4262695 . PMID   25277721.
  20. Bakshi A, Herke SW, Batzer MA, Kim J (2016). "ADNA methylation variation of human-specific Alu repeats". Epigenetics. 11 (2): 163–73. doi:10.1080/15592294.2015.1130518. PMC   4846114 . PMID   26890526.