N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase

N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
Identifiers
EC no.	2.4.1.289
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase (EC 2.4.1.289, WbbL) is an enzyme with systematic name dTDP-6-deoxy-beta-L-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-alpha-L-rhamnosyltransferase. ^{[1] [2]} This enzyme catalyses the following chemical reaction

dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol ${\displaystyle \rightleftharpoons }$ dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol

This enzyme requires Mn²⁺ or Mg²⁺.

References

1. Mills JA, Motichka K, Jucker M, Wu HP, Uhlik BC, Stern RJ, Scherman MS, Vissa VD, Pan F, Kundu M, Ma YF, McNeil M (October 2004). "Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability". The Journal of Biological Chemistry. 279 (42): 43540–6. doi: 10.1074/jbc.M407782200 . PMID   15294902.
2. Grzegorzewicz AE, Ma Y, Jones V, Crick D, Liav A, McNeil MR (December 2008). "Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL". Microbiology. 154 (Pt 12): 3724–30. doi:10.1099/mic.0.2008/023366-0. PMC   2717732 . PMID   19047740.

External links

• N-acetylglucosaminyl-diphospho-decaprenol+L-rhamnosyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)