peptide-O-fucosyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.4.1.221 | ||||||||
CAS no. | 9033-08-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a peptide-O-fucosyltransferase (EC 2.4.1.221) is an enzyme that catalyzes the chemical reaction in which an alpha-L-fucosylpyranoside residue is transferred from GDP-beta-L-fucose to the sidechain oxygen atom of a serine or threonine residue in a protein.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase. Other names in common use include GDP-L-fucose:polypeptide fucosyltransferase, GDP-fucose protein O-fucosyltransferase, and GDP-fucose:polypeptide fucosyltransferase.
GDP-fucose protein O-fucosyltransferase 1 also known as peptide-O-fucosyltransferase 1 (O-FucT-1) is an enzyme that in humans is encoded by the POFUT1 gene.
A fucosyltransferase is an enzyme that transfers an L-fucose sugar from a GDP-fucose donor substrate to an acceptor substrate. The acceptor substrate can be another sugar such as the transfer of a fucose to a core GlcNAc (N-acetylglucosamine) sugar as in the case of N-linked glycosylation, or to a protein, as in the case of O-linked glycosylation produced by O-fucosyltransferase. There are various fucosyltransferases in mammals, the vast majority of which, are located in the Golgi apparatus. The O-fucosyltransferases have recently been shown to localize to the endoplasmic reticulum (ER).
Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.
The enzyme GDP-mannose 4,6-dehydratase (EC 4.2.1.47) catalyzes the chemical reaction
In enzymology, a 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a galactoside 2-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a glycoprotein 3-alpha-L-fucosyltransferase (EC 2.4.1.214) is an enzyme that catalyzes the chemical reaction
In enzymology, a glycoprotein 6-alpha-L-fucosyltransferase (EC 2.4.1.68) is an enzyme that catalyzes the chemical reaction
In enzymology, a fucokinase is an enzyme that catalyzes the chemical reaction
Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.
Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.
Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene, a member of the fringe gene family which also includes the radical fringe (RFNG) and lunatic fringe (LFNG).
Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT9 gene.
Polypeptide N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the GALNT2 gene.
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.
Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.
GDP-mannose 4,6 dehydratase is an enzyme that in humans is encoded by the GMDS gene.
GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene.
Fucose-1-phosphate guanylyltransferase is an enzyme that in humans is encoded by the FPGT gene.