phosphatidylinositol N-acetylglucosaminyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.4.1.198 | ||||||||
CAS no. | 144388-35-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a phosphatidylinositol N-acetylglucosaminyltransferase (EC 2.4.1.198) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are UDP-N-acetylglucosamine and phosphatidylinositol, whereas its two products are UDP and N-acetyl-D-glucosaminylphosphatidylinositol.
The mammalian enzyme is composed of at least six subunits (PIG-A, PIG-H, PIG-C, PIG-P, PIG-Y, and GPI1). PIG-A is the catalytic subunit.
This enzyme belongs to the family of glycosyltransferases, to be specific the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase. Other names in common use include UDP-N-acetyl-D-glucosamine:phosphatidylinositol, N-acetyl-D-glucosaminyltransferase, uridine diphosphoacetylglucosamine, and alpha1,6-acetyl-D-glucosaminyltransferase. This enzyme participates in 3 metabolic pathways: glycosylphosphatidylinositol(gpi)-anchor, ???, and glycan structures - biosynthesis 2.
In enzymology, an UDP-N-acetylglucosamine 2-epimerase is an enzyme that catalyzes the chemical reaction
In enzymology, a N-acetylglucosaminylphosphatidylinositol deacetylase (EC 3.5.1.89) is an enzyme that catalyzes the chemical reaction
In enzymology, an UDP-N-acetylglucosamine 1-carboxyvinyltransferase is an enzyme that catalyzes the first committed step in peptidoglycan biosynthesis of bacteria:
In enzymology, a dolichyl-phosphate alpha-N-acetylglucosaminyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a lipopolysaccharide N-acetylglucosaminyltransferase is an enzyme that catalyzes the chemical reaction
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A is the catalytic subunit of the phosphatidylinositol N-acetylglucosaminyltransferase enzyme, which in humans is encoded by the PIGA gene.
GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.
GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.
Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.
Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.
GPI transamidase component PIG-S is an enzyme that in humans is encoded by the PIGS gene. This gene encodes a protein that is involved in GPI-anchor biosynthesis.
Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.
Subunit P of phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme subunit that in humans is encoded by the PIGP gene.
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene. The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.
dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.
Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the DPM2 gene.
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction
Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction