Phosphatidylinositol N-acetylglucosaminyltransferase

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phosphatidylinositol N-acetylglucosaminyltransferase
Identifiers
EC no. 2.4.1.198
CAS no. 144388-35-2
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MetaCyc metabolic pathway
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In enzymology, a phosphatidylinositol N-acetylglucosaminyltransferase (EC 2.4.1.198) is an enzyme that catalyzes the chemical reaction

UDP-N-acetylglucosamine + phosphatidylinositol UDP + N-acetyl-D-glucosaminylphosphatidylinositol

Thus, the two substrates of this enzyme are UDP-N-acetylglucosamine and phosphatidylinositol, whereas its two products are UDP and N-acetyl-D-glucosaminylphosphatidylinositol.

The mammalian enzyme is composed of at least six subunits (PIG-A, PIG-H, PIG-C, PIG-P, PIG-Y, and GPI1). PIG-A is the catalytic subunit.

This enzyme belongs to the family of glycosyltransferases, to be specific the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase. Other names in common use include UDP-N-acetyl-D-glucosamine:phosphatidylinositol, N-acetyl-D-glucosaminyltransferase, uridine diphosphoacetylglucosamine, and alpha1,6-acetyl-D-glucosaminyltransferase. This enzyme participates in 3 metabolic pathways: glycosylphosphatidylinositol(gpi)-anchor, ???, and glycan structures - biosynthesis 2.

Related Research Articles

<span class="mw-page-title-main">UDP-N-acetylglucosamine 2-epimerase</span> Class of enzymes

In enzymology, an UDP-N-acetylglucosamine 2-epimerase is an enzyme that catalyzes the chemical reaction

In enzymology, a N-acetylglucosaminylphosphatidylinositol deacetylase (EC 3.5.1.89) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</span> Class of enzymes

In enzymology, an UDP-N-acetylglucosamine 1-carboxyvinyltransferase is an enzyme that catalyzes the first committed step in peptidoglycan biosynthesis of bacteria:

In enzymology, a dolichyl-phosphate alpha-N-acetylglucosaminyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a lipopolysaccharide N-acetylglucosaminyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">PIGA</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A is the catalytic subunit of the phosphatidylinositol N-acetylglucosaminyltransferase enzyme, which in humans is encoded by the PIGA gene.

<span class="mw-page-title-main">PIGT</span> Protein-coding gene in the species Homo sapiens

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.

<span class="mw-page-title-main">PIGK</span> Protein-coding gene in the species Homo sapiens

GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.

<span class="mw-page-title-main">GPAA1</span> Protein-coding gene in the species Homo sapiens

Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.

<span class="mw-page-title-main">PIGQ</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.

<span class="mw-page-title-main">PIGC</span> Enzyme

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.

<span class="mw-page-title-main">PIGF</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.

<span class="mw-page-title-main">PIGS (gene)</span> Protein-coding gene in the species Homo sapiens

GPI transamidase component PIG-S is an enzyme that in humans is encoded by the PIGS gene. This gene encodes a protein that is involved in GPI-anchor biosynthesis.

<span class="mw-page-title-main">PIGU</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.

<span class="mw-page-title-main">PIGP</span> Protein-coding gene in the species Homo sapiens

Subunit P of phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme subunit that in humans is encoded by the PIGP gene.

<span class="mw-page-title-main">PIGH</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene. The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.

<span class="mw-page-title-main">DPM3</span> Protein-coding gene in the species Homo sapiens

dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.

<span class="mw-page-title-main">DPM2</span> Protein-coding gene in the species Homo sapiens

Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the DPM2 gene.

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction

Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction

References