Stratum corneum chymotryptic enzyme

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Stratum corneum chymotryptic enzyme
Identifiers
EC no. 3.4.21.117
CAS no. 155215-90-0
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Stratum corneum chymotryptic enzyme (EC 3.4.21.117, kallikrein 7, SCCE, KLK7 , PRSS6, hK7) is an enzyme. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

Cleavage of proteins with aromatic side chains in the P1 position

This enzyme has wide substrate specificity.

References

  1. ↑ Skytt A, Strömqvist M, Egelrud T (June 1995). "Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme". Biochemical and Biophysical Research Communications. 211 (2): 586–9. Bibcode:1995BBRC..211..586S. doi:10.1006/bbrc.1995.1853. PMID   7794273.
  2. ↑ Egelrud T (August 1993). "Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation". The Journal of Investigative Dermatology. 101 (2): 200–4. doi: 10.1111/1523-1747.ep12363804 . PMID   8393902.
  3. ↑ Hansson L, Strömqvist M, Bäckman A, Wallbrandt P, Carlstein A, Egelrud T (July 1994). "Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase". The Journal of Biological Chemistry. 269 (30): 19420–6. doi: 10.1016/S0021-9258(17)32185-3 . PMID   8034709.
  4. ↑ Yousef GM, Scorilas A, Magklara A, Soosaipillai A, Diamandis EP (August 2000). "The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation". Gene. 254 (1–2): 119–28. doi:10.1016/S0378-1119(00)00280-8. PMID   10974542.
  5. ↑ Vasilopoulos Y, Cork MJ, Murphy R, Williams HC, Robinson DA, Duff GW, Ward SJ, Tazi-Ahnini R (July 2004). "Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis". The Journal of Investigative Dermatology. 123 (1): 62–6. doi: 10.1111/j.0022-202X.2004.22708.x . PMID   15191543.
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