Tegomil fumarate

Last updated

Tegomil fumarate
Tegomil fumarate.svg
Clinical data
ATC code
Identifiers
  • dimethyl 3,6,9-trioxaundecane-1,11-diyl di((2E)-but-2-enedioate)
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C18H26O11
Molar mass 418.395 g·mol−1
3D model (JSmol)
  • COC(=O)/C=C/C(=O)OCCOCCOCCOCCOC(=O)/C=C/C(=O)OC
  • InChI=1S/C18H26O11/c1-23-15(19)3-5-17(21)28-13-11-26-9-7-25-8-10-27-12-14-29-18(22)6-4-16(20)24-2/h3-6H,7-14H2,1-2H3/b5-3+,6-4+
  • Key:XBRIIHOHDRTZMQ-GGWOSOGESA-N

Tegomil fumarate is an experimental medication under investigation for the treatment of relapsing remitting multiple sclerosis. [1]

Contents

The mechanism of action of tegomil fumarate is not fully understood but it is thought to act via its main active metabolite monomethyl fumarate. [1] This metabolite activates the NRF2 transcriptional pathway, which reduces inflammation and modulates the activity of immune cells, thereby protecting the cells of the central nervous system from damage. [1]

Society and culture

In May 2025, the Committee for Medicinal Products for Human Use of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Riulvy, intended for the treatment of adults and children from 13 years of age with relapsing remitting multiple sclerosis. [1] The applicant for this medicinal product is Neuraxpharm Pharmaceuticals, S.L. [1] Riulvy is a hybrid medicine of Tecfidera, which has been authorized in the EU since January 2014. [1] Riulvy contains a different active substance but acts via the same active metabolite as Tecfidera, monomethyl fumarate. [1]

Names

Tegomil fumarate is the international nonproprietary name. [2]

References

  1. 1 2 3 4 5 6 7 "Riulvy EPAR". European Medicines Agency (EMA). 23 May 2025. Retrieved 15 June 2025. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  2. ↑ World Health Organization (2024). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 91". WHO Drug Information. 38 (1). hdl: 10665/378096 .


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