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| Other names | ONC-201 |
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| Formula | C24H26N4O |
| Molar mass | 386.499 g·mol−1 |
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Dordaviprone is an investigational new drug that is being evaluated for the treatment of diffuse intrinsic pontine glioma (a type of brain tumor). [1] It is dopamine receptor D2 antagonist and an allosteric activator of the mitochondrial caseinolytic protease P. [2]
The cat, also referred to as domestic cat or house cat, is a small domesticated carnivorous mammal. It is the only domesticated species of the family Felidae. Advances in archaeology and genetics have shown that the domestication of the cat occurred in the Near East around 7500 BC. It is commonly kept as a house pet and farm cat, but also ranges freely as a feral cat avoiding human contact. Valued by humans for companionship and its ability to kill vermin, the cat's retractable claws are adapted to killing small prey like mice and rats. It has a strong, flexible body, quick reflexes, and sharp teeth, and its night vision and sense of smell are well developed. It is a social species, but a solitary hunter and a crepuscular predator. Cat communication includes vocalizations like meowing, purring, trilling, hissing, growling, and grunting as well as cat body language. It can hear sounds too faint or too high in frequency for human ears, such as those made by small mammals. It secretes and perceives pheromones.
Earth is the third planet from the Sun and the only astronomical object known to harbor life. This is enabled by Earth being an ocean world, the only one in the Solar System sustaining liquid surface water. Almost all of Earth's water is contained in its global ocean, covering 70.8% of Earth's crust. The remaining 29.2% of Earth's crust is land, most of which is located in the form of continental landmasses within Earth's land hemisphere. Most of Earth's land is somewhat humid and covered by vegetation, while large sheets of ice at Earth's polar deserts retain more water than Earth's groundwater, lakes, rivers and atmospheric water combined. Earth's crust consists of slowly moving tectonic plates, which interact to produce mountain ranges, volcanoes, and earthquakes. Earth has a liquid outer core that generates a magnetosphere capable of deflecting most of the destructive solar winds and cosmic radiation.
Jennifer Lynn Affleck, also known by her nickname J.Lo, is an American singer, songwriter, actress, dancer and businesswoman. Lopez is regarded as one of the most influential Latin entertainers of her time, credited with breaking barriers for Latino Americans in Hollywood and helping propel the Latin pop movement in music. She is also noted for her impact on popular culture through fashion, branding, and shifting mainstream beauty standards.
The Lord of the Rings is an epic high fantasy novel by the English author and scholar J. R. R. Tolkien. Set in Middle-earth, the story began as a sequel to Tolkien's 1937 children's book The Hobbit, but eventually developed into a much larger work. Written in stages between 1937 and 1949, The Lord of the Rings is one of the best-selling books ever written, with over 150 million copies sold.
Michael Andrew Fox, known professionally as Michael J. Fox, is a Canadian and American activist and retired actor. Beginning his career as a child actor in the 1970s, he rose to prominence portraying Alex P. Keaton on the NBC sitcom Family Ties (1982–1989) and Marty McFly in the Back to the Future film trilogy (1985–1990). Fox went on to star in films such as Teen Wolf (1985), The Secret of My Success (1987), Casualties of War (1989), Doc Hollywood (1991), and The Frighteners (1996). He returned to television on the ABC sitcom Spin City in the lead role of Mike Flaherty (1996–2000).
Johnson & Johnson (J&J) is an American multinational pharmaceutical, biotechnology, and medical technologies corporation headquartered in New Brunswick, New Jersey, and publicly traded on the New York Stock Exchange. Its common stock is a component of the Dow Jones Industrial Average, and the company is ranked No. 40 on the 2023 Fortune 500 list of the largest United States corporations. In 2023, the company was ranked 40th in the Forbes Global 2000. Johnson & Johnson has a global workforce of approximately 130,000 employees who are led by the company's current chairman and chief executive officer, Joaquin Duato.
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Humans or modern humans are the most common and widespread species of primate, and the last surviving species of the genus Homo. They are great apes characterized by their hairlessness, bipedalism, and high intelligence. Humans have large brains, enabling more advanced cognitive skills that enable them to thrive and adapt in varied environments, develop highly complex tools, and form complex social structures and civilizations. Humans are highly social, with individual humans tending to belong to a multi-layered network of cooperating, distinct, or even competing social groups – from families and peer groups to corporations and political states. As such, social interactions between humans have established a wide variety of values, social norms, languages, and traditions, each of which bolsters human society. Humans are also highly curious, with the desire to understand and influence phenomena having motivated humanity's development of science, technology, philosophy, mythology, religion, and other frameworks of knowledge; humans also study themselves through such domains as anthropology, social science, history, psychology, and medicine. There are estimated to be more than eight billion humans alive.
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The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began with an outbreak of COVID-19 in Wuhan, China, in December 2019. It spread to other areas of Asia, and then worldwide in early 2020. The World Health Organization (WHO) declared the outbreak a public health emergency of international concern (PHEIC) on 30 January 2020, and assessed the outbreak had become a pandemic on 11 March.
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