Masoprocol

Last updated
Masoprocol
Masoprocol.svg
Clinical data
Trade names Actinex
AHFS/Drugs.com Micromedex Detailed Consumer Information
Routes of
administration 		Topical
ATC code
Pharmacokinetic data
Bioavailability Very low
Identifiers
  • 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.044.172 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C18H22O4
Molar mass 302.370 g·mol−1
3D model (JSmol)
  • Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2
  • InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ Yes check.svgY
  • Key:HCZKYJDFEPMADG-TXEJJXNPSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. It is the meso form of nordihydroguaiaretic acid that is taken by mouth. The substance is being studied in the treatment of prostate cancer.

Contents

Masoprocol is also called NDGA, and Actinex.

Mechanism

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor. [1]

References

  1. ↑ Gowri MS, Azhar RK, Kraemer FB, Reaven GM, Azhar S (September 2000). "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". American Journal of Physiology. Endocrinology and Metabolism. 279 (3): E593-600. doi: 10.1152/ajpendo.2000.279.3.E593 . PMID   10950827.
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