Clinical data | |
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Trade names | Beleodaq |
Other names | PXD101 |
AHFS/Drugs.com | beleodaq |
Routes of administration | Intravenous (IV) |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | 100% (IV) |
Protein binding | 92.9–95.8% [1] |
Metabolism | UGT1A1 |
Excretion | Urine |
Identifiers | |
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Chemical and physical data | |
Formula | C15H14N2O4S |
Molar mass | 318.35 g·mol−1 |
3D model (JSmol) | |
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Belinostat (trade name Beleodaq, previously known as PXD101) is a histone deacetylase inhibitor drug developed by TopoTarget for the treatment of hematological malignancies and solid tumors. [2]
It was approved in July 2014 by the US FDA to treat peripheral T-cell lymphoma. [3]
In 2007 preliminary results were released from the Phase II clinical trial of intravenous belinostat in combination with carboplatin and paclitaxel for relapsed ovarian cancer. [4] Final results in late 2009 of a phase II trial for T-cell lymphoma were encouraging. [5] Belinostat has been granted orphan drug and fast track designation by the FDA, [6] and was approved in the US for the use against peripheral T-cell lymphoma on 3 July 2014. [3] It is not approved in Europe as of August 2014 [update] . [7]
The approved pharmaceutical formulation is given intravenously. [8] : 180 Belinostat is primarily metabolized by UGT1A1; the initial dose should be reduced if the recipient is known to be homozygous for the UGT1A1*28 allele. [8] : 179 and 181
Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, others being hormonal therapy and cytotoxic chemotherapy. As a form of molecular medicine, targeted therapy blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth, rather than by simply interfering with all rapidly dividing cells. Because most agents for targeted therapy are biopharmaceuticals, the term biologic therapy is sometimes synonymous with targeted therapy when used in the context of cancer therapy. However, the modalities can be combined; antibody-drug conjugates combine biologic and cytotoxic mechanisms into one targeted therapy.
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