Human thermoregulation

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As in other mammals, human thermoregulation is an important aspect of homeostasis. In thermoregulation, body heat is generated mostly in the deep organs, especially the liver, brain, and heart, and in contraction of skeletal muscles. [1] Humans have been able to adapt to a great diversity of climates, including hot humid and hot arid. High temperatures pose serious stress for the human body, placing it in great danger of injury or even death. For humans, adaptation to varying climatic conditions includes both physiological mechanisms resulting from evolution and behavioural mechanisms resulting from conscious cultural adaptations. [2] [3]

Contents

There are four avenues of heat loss: convection, conduction, radiation, and evaporation. If skin temperature is greater than that of the surroundings, the body can lose heat by radiation and conduction. But, if the temperature of the surroundings is greater than that of the skin, the body actually gains heat by radiation and conduction. In such conditions, the only means by which the body can rid itself of heat is by evaporation. So, when the surrounding temperature is higher than the skin temperature, anything that prevents adequate evaporation will cause the internal body temperature to rise. [4] During sports activities, evaporation becomes the main avenue of heat loss. [5] Humidity affects thermoregulation by limiting sweat evaporation and thus heat loss. [6]

Humans cannot survive prolonged exposure to a wet-bulb temperature above 35 °C (95 °F). Such a temperature used to be thought not to occur on Earth's surface but has been recorded in some parts of the Indus Valley and Persian Gulf. Occurrence of conditions too hot and humid for human life is expected to increase in the future due to global warming. [7]

Control system

Simplified control circuit of human thermoregulation. Thermoregulation simplified.png
Simplified control circuit of human thermoregulation.

The core temperature of a human is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system, [9] and more specifically by the anterior hypothalamic nucleus and the adjacent preoptic area regions of the hypothalamus. As core temperature varies from the set point, endocrine production initiates control mechanisms to increase or decrease energy production/dissipation as needed to return the temperature toward the set point (see figure). [8]

In hot conditions

Electric fan used in hot weather Electric fan being used in hot weather in Australia-11Jan2010.jpg
Electric fan used in hot weather

In hot and humid conditions

In general, humans appear physiologically well adapted to hot dry conditions. [11] However, effective thermoregulation is reduced in hot, humid environments such as the Red Sea and Persian Gulf (where moderately hot summer temperatures are accompanied by unusually high vapor pressures), tropical environments, and deep mines where the atmosphere can be water-saturated. [11] [2] In hot-humid conditions, clothing can impede efficient evaporation. [3] In such environments, it helps to wear light clothing such as cotton, that is pervious to sweat but impervious to radiant heat from the sun. This minimizes the gaining of radiant heat, while allowing as much evaporation to occur as the environment will allow. Clothing such as plastic fabrics that are impermeable to sweat and thus do not facilitate heat loss through evaporation can actually contribute to heat stress. [6]

In cold conditions

Fitness

The more physically fit a person is, the greater their ability to adjust to temperature variation. This includes adapting for heat (keeping cool) [12] and for cold (keeping warm). [13]

Age

Age can be a factor in a person's ability to adapt to temperature variations. Studies have shown that younger people adapt more efficiently to contact with cold surfaces than elderly people. Notably, a good level of fitness allowed the elderly people to cope better and offset somewhat the drop off to their ability to thermoregulate due to old age. [14]

Body mass

A high body mass has been found to help with thermoregulation in regard to adapting for hot environments. This is considered on the basis that the levels of body fat were within healthy ranges i.e. the person's muscle-to-fat ratio was healthy. [15] However, extra body fat has been shown to offer some benefit in terms of keeping warm, especially during immersion in cold water. For this reason long distance outdoor swimmers often have a generous layer of body fat. This is not necessarily always the case though, and high levels of physical fitness can allow thinner swimmers to also perform effectively in cold water environments. [16]

Uses of hypothermia

Adjusting the human body temperature downward has been used therapeutically, in particular, as a method of stabilizing a body following trauma. It has been suggested that adjusting the adenosine A1 receptor of the hypothalamus may allow humans to enter a hibernation-like state of reduced body temperature, which could be useful for applications such as long-duration space flight. [17]

The thermoregulatory sweat test (TST) can be used to diagnose certain conditions that cause abnormal temperature regulation and defects in sweat production in the body. To perform the test, the patient is placed in a chamber that slowly rises in temperature. Before the chamber is heated, the patient is coated with a special kind of indicator powder that will change in color when sweat is produced. This powder, when changing color, will be useful in visualizing which skin is sweating versus not sweating. Results of the patient's sweat pattern will be documented by digital photography, and abnormal TST patterns can indicate if there is dysfunction in the autonomic nervous system. Certain differentials can be made depending on the type of sweat pattern found from the TST (along with history and clinical presentation) including hyperhidrosis, small fiber and autonomic neuropathies, multiple system atrophy, Parkinson disease with autonomic dysfunction, and pure autonomic failure. [18]

Related Research Articles

<span class="mw-page-title-main">Warm-blooded</span> Animal species that can maintain a body temperature higher than their environment

Warm-blooded is an informal term referring to animal species whose bodies maintain a temperature higher than that of their environment. In particular, homeothermic species maintain a stable body temperature by regulating metabolic processes. Other species have various degrees of thermoregulation.

<span class="mw-page-title-main">Hyperthermia</span> Elevated body temperature due to failed thermoregulation

Hyperthermia, also known simply as overheating, is a condition in which an individual's body temperature is elevated beyond normal due to failed thermoregulation. The person's body produces or absorbs more heat than it dissipates. When extreme temperature elevation occurs, it becomes a medical emergency requiring immediate treatment to prevent disability or death. Almost half a million deaths are recorded every year from hyperthermia.

<span class="mw-page-title-main">Perspiration</span> Fluid secreted from sudoriferous glands

Perspiration, also known as sweat, is the fluid secreted by sweat glands in the skin of mammals.

<span class="mw-page-title-main">Hypothermia</span> Human body core temperature below 35.0 °C (95.0 °F)

Hypothermia is defined as a body core temperature below 35.0 °C (95.0 °F) in humans. Symptoms depend on the temperature. In mild hypothermia, there is shivering and mental confusion. In moderate hypothermia, shivering stops and confusion increases. In severe hypothermia, there may be hallucinations and paradoxical undressing, in which a person removes their clothing, as well as an increased risk of the heart stopping.

<span class="mw-page-title-main">Endotherm</span> Organism that maintains body temperature largely by heat from internal bodily functions

An endotherm is an organism that maintains its body at a metabolically favorable temperature, largely by the use of heat released by its internal bodily functions instead of relying almost purely on ambient heat. Such internally generated heat is mainly an incidental product of the animal's routine metabolism, but under conditions of excessive cold or low activity an endotherm might apply special mechanisms adapted specifically to heat production. Examples include special-function muscular exertion such as shivering, and uncoupled oxidative metabolism, such as within brown adipose tissue.

<span class="mw-page-title-main">Thermoregulation</span> Ability of an organism to keep its body temperature within certain boundaries

Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different. A thermoconforming organism, by contrast, simply adopts the surrounding temperature as its own body temperature, thus avoiding the need for internal thermoregulation. The internal thermoregulation process is one aspect of homeostasis: a state of dynamic stability in an organism's internal conditions, maintained far from thermal equilibrium with its environment. If the body is unable to maintain a normal temperature and it increases significantly above normal, a condition known as hyperthermia occurs. Humans may also experience lethal hyperthermia when the wet bulb temperature is sustained above 35 °C (95 °F) for six hours. Work in 2022 established by experiment that a wet-bulb temperature exceeding 30.55°C caused uncompensable heat stress in young, healthy adult humans. The opposite condition, when body temperature decreases below normal levels, is known as hypothermia. It results when the homeostatic control mechanisms of heat within the body malfunction, causing the body to lose heat faster than producing it. Normal body temperature is around 37°C(98.6°F), and hypothermia sets in when the core body temperature gets lower than 35 °C (95 °F). Usually caused by prolonged exposure to cold temperatures, hypothermia is usually treated by methods that attempt to raise the body temperature back to a normal range. It was not until the introduction of thermometers that any exact data on the temperature of animals could be obtained. It was then found that local differences were present, since heat production and heat loss vary considerably in different parts of the body, although the circulation of the blood tends to bring about a mean temperature of the internal parts. Hence it is important to identify the parts of the body that most closely reflect the temperature of the internal organs. Also, for such results to be comparable, the measurements must be conducted under comparable conditions. The rectum has traditionally been considered to reflect most accurately the temperature of internal parts, or in some cases of sex or species, the vagina, uterus or bladder.

<span class="mw-page-title-main">Ectotherm</span> Organism where internal heating sources are small or negligible

An ectotherm, more commonly referred to as a "cold-bloodedanimal", is an animal in which internal physiological sources of heat are of relatively small or of quite negligible importance in controlling body temperature. Such organisms rely on environmental heat sources, which permit them to operate at very economical metabolic rates.

<span class="mw-page-title-main">Exercise physiology</span>

Exercise physiology is the physiology of physical exercise. It is one of the allied health professions, and involves the study of the acute responses and chronic adaptations to exercise. Exercise physiologists are the highest qualified exercise professionals and utilise education, lifestyle intervention and specific forms of exercise to rehabilitate and manage acute and chronic injuries and conditions.

Chills is a feeling of coldness occurring during a high fever, but sometimes is also a common symptom which occurs alone in specific people. It occurs during fever due to the release of cytokines and prostaglandins as part of the inflammatory response, which increases the set point for body temperature in the hypothalamus. The increased set point causes the body temperature to rise (pyrexia), but also makes the patient feel cold or chills until the new set point is reached. Shivering also occurs along with chills because the patient's body produces heat during muscle contraction in a physiological attempt to increase body temperature to the new set point. When it does not accompany a high fever, it is normally a light chill.

At the end of pregnancy, the fetus must take the journey of childbirth to leave the reproductive mother. Upon its entry to the air-breathing world, the newborn must begin to adjust to life outside the uterus. This is true for all viviparous animals; this article discusses humans as the most-researched example.

Ecophysiology, environmental physiology or physiological ecology is a biological discipline that studies the response of an organism's physiology to environmental conditions. It is closely related to comparative physiology and evolutionary physiology. Ernst Haeckel's coinage bionomy is sometimes employed as a synonym.

Normal human body temperature is the typical temperature range found in humans. The normal human body temperature range is typically stated as 36.5–37.5 °C (97.7–99.5 °F).

<span class="mw-page-title-main">Median preoptic nucleus</span> Nucleus in the anterior hypothalamus

The median preoptic nucleus is located dorsal to the other three nuclei of the preoptic area of the anterior hypothalamus. The hypothalamus is located just beneath the thalamus, the main sensory relay station of the nervous system, and is considered part of the limbic system, which also includes structures such as the hippocampus and the amygdala. The hypothalamus is highly involved in maintaining homeostasis of the body, and the median preoptic nucleus is no exception, contributing to regulation of blood composition, body temperature, and non-REM sleep.

<span class="mw-page-title-main">Axon reflex</span>

The axon reflex is the response stimulated by peripheral nerves of the body that travels away from the nerve cell body and branches to stimulate target organs. Reflexes are single reactions that respond to a stimulus making up the building blocks of the overall signaling in the body's nervous system. Neurons are the excitable cells that process and transmit these reflex signals through their axons, dendrites, and cell bodies. Axons directly facilitate intercellular communication projecting from the neuronal cell body to other neurons, local muscle tissue, glands and arterioles. In the axon reflex, signaling starts in the middle of the axon at the stimulation site and transmits signals directly to the effector organ skipping both an integration center and a chemical synapse present in the spinal cord reflex. The impulse is limited to a single bifurcated axon, or a neuron whose axon branches into two divisions and does not cause a general response to surrounding tissue.

Endothermic organisms known as homeotherms maintain internal temperatures with minimal metabolic regulation within a range of ambient temperatures called the thermal neutral zone (TNZ). Within the TNZ the basal rate of heat production is equal to the rate of heat loss to the environment. Homeothermic organisms adjust to the temperatures within the TNZ through different responses requiring little energy.

<span class="mw-page-title-main">Heat stroke</span> Condition caused by excessive exposure to high temperatures.

Heat stroke or heatstroke, also known as sun-stroke, is a severe heat illness that results in a body temperature greater than 40.0 °C (104.0 °F), along with red skin, headache, dizziness, and confusion. Sweating is generally present in exertional heatstroke, but not in classic heatstroke. The start of heat stroke can be sudden or gradual. Heatstroke is a life-threatening condition due to the potential for multi-organ dysfunction, with typical complications including seizures, rhabdomyolysis, or kidney failure.

Cold and heat adaptations in humans are a part of the broad adaptability of Homo sapiens. Adaptations in humans can be physiological, genetic, or cultural, which allow people to live in a wide variety of climates. There has been a great deal of research done on developmental adjustment, acclimatization, and cultural practices, but less research on genetic adaptations to colder and hotter temperatures.

<span class="mw-page-title-main">Skin temperature</span> Temperature at the outer surface of a living body

Skin temperature is the temperature of the outermost surface of the body. Normal human skin temperature on the trunk of the body varies between 33.5 and 36.9 °C, though the skin's temperature is lower over protruding parts, like the nose, and higher over muscles and active organs. Recording skin temperature presents extensive difficulties. Although it is not a clear indicator of internal body temperature, skin temperature is significant in assessing the healthy function of skin. Some experts believe the physiological significance of skin temperature has been overlooked, because clinical analysis has favoured measuring temperatures of the mouth, armpit, and/or rectum. Temperatures of these parts typically are consistent with internal body temperature.

<span class="mw-page-title-main">Clothing physiology</span> Study of clothings interaction with the human body

Clothing physiology is a branch of science that studies the interaction between clothing and the human body, with a particular focus on how clothing affects the physiological and psychological responses of individuals to different environmental conditions. The goal of clothing physiology research is to develop a better understanding of how clothing can be designed to optimize comfort, performance, and protection for individuals in various settings, including outdoor recreation, occupational environments, and medical contexts.

Thermal balance of a diver occurs when the total heat exchanged between the diver and their surroundings results in a stable temperature of the diver. Ideally this is within the range of normal human body temperature. Thermal status of the diver is the temperature distribution and heat balance of the diver. The terms are frequently used as synonyms. Thermoregulation is the process by which an organism keeps its body temperature within specific bounds, even when the surrounding temperature is significantly different. The internal thermoregulation process is one aspect of homeostasis: a state of dynamic stability in an organism's internal conditions, maintained far from thermal equilibrium with its environment. If the body is unable to maintain a normal human body temperature and it increases significantly above normal, a condition known as hyperthermia occurs. The opposite condition, when body temperature decreases below normal levels, is known as hypothermia. It occurs when the body loses heat faster than producing it. The core temperature of the body normally remains steady at around 36.5–37.5 °C (97.7–99.5 °F). Only a small amount of hypothermia or hyperthermia can be tolerated before the condition becomes debiltating, further deviation can be fatal. Hypothermia does not easily occur in a diver with reasonable passive thermal insulation over a moderate exposure period, even in very cold water.

References

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