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Tremelimumab, sold under the brand name Imjudo, is a fully human monoclonal antibody used for the treatment of hepatocellular carcinoma. Tremelimumab is designed to attach to and block CTLA-4, a protein that controls the activity of T cells, which are part of the immune system.
Ofatumumab is a fully human monoclonal antibody to CD20, which appears to provide rapid B-cell depletion. Under the brand name Kesimpta, it is approved for the treatment of multiple sclerosis in the United States as well as in the European Union and other regions. Under the brand name Arzerra, it is approved for the treatment of certain types of chronic lymphocytic leukemia (CLL) in the United States. It is sold by Novartis under license from Genmab.
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Tixagevimab/cilgavimab, sold under the brand name Evusheld, is a combination of two human monoclonal antibodies, tixagevimab (AZD8895) and cilgavimab (AZD1061) targeted against the surface spike protein of SARS-CoV-2 used to prevent COVID-19. It is being developed by British-Swedish multinational pharmaceutical and biotechnology company AstraZeneca. It is co-packaged and given as two separate consecutive intramuscular injections.
References
- 1 2 "Idefirix". Therapeutic Goods Administration (TGA). 19 July 2023. Retrieved 10 September 2023.
- ↑ "Idefirix (Hansa Biopharma (Australia) Pty Ltd)". Therapeutic Goods Administration (TGA). 28 July 2023. Retrieved 10 September 2023.
- 1 2 3 4 5 6 7 8 9 10 "Imlifidase: EPAR". European Medicines Agency (EMA). 25 June 2020. Archived from the original on 24 October 2020. Retrieved 24 September 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ↑ "Idefirix Product information". Union Register of medicinal products. Retrieved 3 March 2023.
- ↑ "New treatment to enable kidney transplant in highly sensitized patients". European Medicines Agency (Press release). 26 June 2020. Archived from the original on 29 June 2020. Retrieved 26 June 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ↑ "EU/3/16/1826". European Medicines Agency (EMA). 12 January 2017. Archived from the original on 29 June 2020. Retrieved 27 June 2020.
This article incorporates text from this source, which is in the public domain . - 1 2 "EU/3/18/2096". European Medicines Agency (EMA). 13 February 2019. Archived from the original on 28 June 2020. Retrieved 27 June 2020. This article incorporates text from this source, which is in the public domain .
- ↑ "Imlifidase Orphan Drug Designation and Approval". U.S. Food and Drug Administration (FDA). 3 July 2018. Archived from the original on 29 June 2020. Retrieved 27 June 2020.
- ↑ "Imlifidase Orphan Drug Designation and Approval". U.S. Food and Drug Administration (FDA). 14 February 2018. Archived from the original on 28 June 2020. Retrieved 27 June 2020.
