This is a detailed list of human spaceflights from 2021 to present.
| # | Crew | Launch spacecraft | Habitation | Return spacecraft | Brief mission summary | |
|---|---|---|---|---|---|---|
| 329 | | 9 April 2021 | ISS (crew 64/65) | 17 October 2021 | ISS crew rotation. | |
| | ISS (crew 64/65/66) | 30 March 2022 | ||||
| 330 | | 23 April 2021 | ISS (crew 65/66) | 9 November 2021 | ISS crew rotation. | |
| — | | 22 May 2021 | First human spaceflight from the State of New Mexico. Reached an altitude of 89.24 km (55.45 mi), crossing the U.S. definition of space, but not the FAI's definition. | |||
| 331 | | 17 June 2021 | TSS | 17 September 2021 | First crew to Tiangong Space Station. | |
| — | | 11 July 2021 | Reached an altitude of 86 km (53 mi), crossing the U.S. definition of space. | |||
| 332 | | 20 July 2021 | Reached an altitude of 107 km (66 mi), crossing the FAI definition of space. | |||
| 333 | | 16 September 2021 | 18 September 2021 | |||
| 334 | | 5 October 2021 | ISS (Vyzov) | 17 October 2021 | ISS crew rotation. | |
| | ISS (crew 65/66) | 30 March 2022 | ||||
| 335 | | 13 October 2021 | Reached an altitude of 107 km (66 mi), crossing the FAI definition of space. | |||
| 336 | | 15 October 2021 | TSS | 16 April 2022 | Second crew to Tiangong Space Station. | |
| 337 | | 11 November 2021 | ISS (crew 66/67) | 6 May 2022 | ISS crew rotation. | |
| 338 | | 8 December 2021, | ISS | 20 December 2021, | ||
| 339 | | 11 December 2021 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 340 | | 18 March 2022, | ISS (crew 66/67) | 29 September 2022, | ISS crew rotation. | |
| 341 | | 31 March 2022 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 342 | | 8 April 2022, | ISS | 25 April 2022, | ||
| 343 | | 27 April 2022 | ISS (crew 67/68) | 14 October 2022 | ISS crew rotation. | |
| 344 | | 4 June 2022 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 345 | | 5 June 2022 | TSS | 4 December 2022 | Third crew to Tiangong Space Station. | |
| 346 | | 4 August 2022 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 347 | | 21 September 2022, | ISS (crew 67/68/69) | 27 September 2023, | ISS crew rotation. | |
| 348 | | 5 October 2022 | ISS (crew 68) | 12 March 2023 | ISS crew rotation. | |
| 349 | | 29 November 2022 | TSS | 3 June 2023 | Fourth crew to Tiangong Space Station. | |
| 350 | | 2 March 2023 | ISS (crew 68/69) | 4 September 2023 | ISS crew rotation. | |
| 351 | | 21 May 2023 | ISS | 31 May 2023 | ||
| — | | 25 May 2023 | Reached an altitude of 87.2 km (54.2 mi), crossing the U.S. definition of space. | |||
| 352 | | 30 May 2023 | TSS | 31 October 2023 | Fifth crew to Tiangong Space Station. | |
| — | | 29 June 2023 | Reached an altitude of 85.1 km (52.9 mi), crossing the U.S. definition of space. | |||
| — | | 10 August 2023 | Reached an altitude of 88.5 km (55.0 mi), crossing the U.S. definition of space. | |||
| 353 | | 26 August 2023 | ISS (crew 69/70) | 12 March 2024 | ISS crew rotation. | |
| — | | 8 September 2023 | Reached an altitude of 88.56 km (55 mi), crossing the U.S. definition of space. | |||
| 354 | | 15 September 2023, | ISS (69/70/71) | 23 September 2024 | ISS crew rotation. | |
| | ISS (crew 69/70) | 6 April 2024, | ||||
| — | | 6 October 2023 | Reached an altitude of 87.38 km (54.3 mi), crossing the U.S. definition of space. | |||
| 355 | | 26 October 2023 | TSS | 30 April 2024 | Sixth crew to Tiangong Space Station. | |
| — | | 2 November 2023 | Reached an altitude of 87.2 km (54.2 mi), crossing the U.S. definition of space. | |||
| 356 | | 18 January 2024, | ISS | 09 February 2024, | ||
| — | | 26 January 2024 | Reached an altitude of 88.8 km (55.2 mi), crossing the U.S. definition of space. | |||
| 357 | | 4 March 2024 | ISS (crew 70/71) | 25 October 2024 | ISS crew rotation. | |
| 358 | | 23 March 2024, | ISS | 6 April 2024, | ISS EP-21. | |
| | ISS (70/71) | 23 September 2024 | ISS crew rotation. | |||
| 359 | | 25 April 2024 | TSS | 3 November 2024 | Seventh crew to Tiangong Space Station. | |
| 360 | | 19 May 2024 | Reached an altitude of 106 km (66 mi), crossing the FAI definition of space. | |||
| 361 | | 5 June 2024 | ISS | 18 March 2025 | Crewed Flight Test to International Space Station. | |
| — | | 8 June 2024 | Reached an altitude of 87.5 km (54.4 mi), crossing the U.S. definition of space. | |||
| 362 | | 29 August 2024 | Reached an altitude of 104 km (65 mi), crossing the FAI definition of space. | |||
| 363 | | 10 September 2024 | 15 September 2024 | First private spacewalk. | ||
| 364 | | 11 September 2024, | ISS (crew 71/72) | 20 April 2025, | ISS crew rotation. | |
| 365 | | 28 September 2024 | ISS (crew 72) | 18 March 2025 | ISS crew rotation. | |
| 366 | | 29 October 2024 | TSS | 29 April 2025 | Tiangong Space Station crew rotation. | |
| 367 | | 22 November 2024 | Reached an altitude of 104 km (65 mi), crossing the FAI definition of space. | |||
| 368 | | 25 February 2025 | Reached an altitude of 107 km (66 mi), crossing the FAI definition of space. | |||
| 369 | | 14 March 2025 | ISS (crew 72/73) | in orbit | ISS crew rotation. | |
| 370 | | 1 April 2025 | 4 April 2025 | First crewed spaceflight to enter a polar orbit around Earth. [6] | ||
| 371 | | 8 April 2025, | ISS (crew 72/73) | in orbit | ISS crew rotation. | |
| 372 | | 14 April 2025 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 373 | | 24 April 2025 | TSS | in orbit | Tiangong Space Station crew rotation. | |
| 374 | | 31 May 2025 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 375 | | 25 June 2025, | ISS | 15 July 2025 | ||
| 376 | 29 June 2025 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | ||||
| 377 | | 1 August 2025 | ISS (crew 73/74) | in orbit | ISS crew rotation. | |
| 378 |
| 3 August 2025 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 379 | 8 October 2025 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | ||||