This is a detailed list of human spaceflights from 2021 to present.
- Green indicates a suborbital flight (including flights that failed to attain intended orbit).
| # | Crew | Launch spacecraft | Habitation | Return spacecraft | Brief mission summary | |
|---|---|---|---|---|---|---|
| 329 |  Oleg Novitsky (3) | 9 April 2021 Soyuz MS-18 | ISS (crew 64/65) | 17 October 2021 Soyuz MS-18 | ISS crew rotation. | |
Pyotr Dubrov  Mark T. Vande Hei (2) | ISS (crew 64/65/66) | 30 March 2022 Soyuz MS-19 | ||||
| 330 | Shane Kimbrough (3) K. Megan McArthur (2) Akihiko Hoshide (3) Thomas Pesquet (2) | 23 April 2021 SpaceX Crew-2, Endeavour | ISS (crew 65/66) | 9 November 2021 SpaceX Crew-2, Endeavour | ISS crew rotation. | |
| — | Frederick W. Sturckow | 22 May 2021 | First human spaceflight from the State of New Mexico. Reached an altitude of 89.24 km (55.45 mi), crossing the U.S. definition of space, but not the FAI's definition. | |||
| 331 |  Nie Haisheng (3) Liu Boming (2) Tang Hongbo (1) | 17 June 2021 Shenzhou 12 | TSS | 17 September 2021 Shenzhou 12 | First crew to Tiangong Space Station. | |
| — |  David Mackay Michael Masucci Beth Moses Richard Branson Colin Bennett Sirisha Bandla | 11 July 2021 | Reached an altitude of 86 km (53 mi), crossing the U.S. definition of space. | |||
| 332 | Jeff Bezos Mark Bezos Wally Funk  Oliver Daemen | 20 July 2021 | Reached an altitude of 107 km (66 mi), crossing the FAI definition of space. | |||
| 333 | Jared Isaacman (1) Sian Proctor Hayley Arceneaux Christopher Sembroski | 16 September 2021 Inspiration4, Resilience | 18 September 2021 Inspiration4, Resilience | |||
| 334 | Klim Shipenko Yulia Peresild | 5 October 2021 Soyuz MS-19 | ISS (Vyzov) | 17 October 2021 Soyuz MS-18 | ISS crew rotation. | |
| Anton Shkaplerov (4) | ISS (crew 65/66) | 30 March 2022 Soyuz MS-19 | ||||
| 335 | Audrey Powers  Chris Boshuizen Glen de Vries  William Shatner | 13 October 2021 | Reached an altitude of 107 km (66 mi), crossing the FAI definition of space. | |||
| 336 | Zhai Zhigang (2) Wang Yaping (2) Ye Guangfu (1) | 15 October 2021 Shenzhou 13 | TSS | 16 April 2022 Shenzhou 13 | Second crew to Tiangong Space Station. | |
| 337 | Raja Chari Thomas Marshburn (3) Kayla Barron  Matthias Maurer | 11 November 2021 SpaceX Crew-3, Endurance | ISS (crew 66/67) | 6 May 2022 SpaceX Crew-3, Endurance | ISS crew rotation. | |
| 338 | Alexander Misurkin (3) Yusaku Maezawa Yozo Hirano | 8 December 2021, Soyuz MS-20 | ISS | 20 December 2021, Soyuz MS-20 | ||
| 339 | Laura Shepard Churchley Michael Strahan Dylan Taylor Evan Dick Lane Bess Cameron Bess | 11 December 2021 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 340 | Oleg Artemyev (3) Denis Matveev Sergey Korsakov | 18 March 2022, Soyuz MS-21 | ISS (crew 66/67) | 29 September 2022, Soyuz MS-21 | ISS crew rotation. | |
| 341 | Marty Allen Sharon Hagle Marc Hagle Jim Kitchen George Nield Gary Lai | 31 March 2022 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 342 | /  Michael López-Alegría (5) Larry Connor Mark Pathy  Eytan Stibbe | 8 April 2022, Axiom Mission 1, Endeavour | ISS | 25 April 2022, Axiom Mission 1, Endeavour | ||
| 343 | Kjell N. Lindgren (2) Robert Hines  Samantha Cristoforetti (2) Jessica Watkins | 27 April 2022 SpaceX Crew-4, Freedom | ISS (crew 67/68) | 14 October 2022 SpaceX Crew-4, Freedom | ISS crew rotation. | |
| 344 | Hamish Harding  Victor Correa Hespanha Evan Dick (2) Katya Echazarreta Jaison Robinson Victor Vescovo | 4 June 2022 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 345 | Chen Dong (2) Liu Yang (2) Cai Xuzhe (1) | 5 June 2022 Shenzhou 14 | TSS | 4 December 2022 Shenzhou 14 | Third crew to Tiangong Space Station. | |
| 346 | Coby Cotton  Mário Ferreira Vanessa O'Brien Clint Kelly III Sara Sabry Steve Young | 4 August 2022 | Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space. | |||
| 347 | Sergey Prokopyev (2) Dmitry Petelin Francisco Rubio | 21 September 2022, Soyuz MS-22 | ISS (crew 67/68/69) | 27 September 2023, Soyuz MS-23 | ISS crew rotation. | |
| 348 | Nicole Aunapu Mann Josh A. Cassada Koichi Wakata (5) Anna Kikina | 5 October 2022 SpaceX Crew-5, Endurance | ISS (crew 68) | 12 March 2023 SpaceX Crew-5, Endurance | ISS crew rotation. | |
| 349 | Fei Junlong (2) Deng Qingming Zhang Lu | 29 November 2022 Shenzhou 15 | TSS | 3 June 2023 Shenzhou 15 | Fourth crew to Tiangong Space Station. | |
| 350 | Stephen G. Bowen (4) Warren Hoburg  Sultan Al Neyadi Andrey Fedyaev | 2 March 2023 SpaceX Crew-6, Endeavour | ISS (crew 68/69) | 4 September 2023 SpaceX Crew-6, Endeavour | ISS crew rotation. | |
| 351 | Peggy Whitson (4) John Shoffner  Ali AlQarni Rayyanah Barnawi | 21 May 2023 Axiom Mission 2, Freedom | ISS | 31 May 2023 Axiom Mission 2, Freedom | ||
| — | Michael Masucci Frederick W. Sturckow Beth Moses Luke Mays Jamila Gilbert Christopher Huie | 25 May 2023 | Reached an altitude of 87.2 km (54.2 mi), crossing the U.S. definition of space. | |||
| 352 | Jing Haipeng (4) Zhu Yangzhu Gui Haichao | 30 May 2023 Shenzhou 16 | TSS | 31 October 2023 Shenzhou 16 | Fifth crew to Tiangong Space Station. | |
| — | Michael Masucci Walter Villadei Angelo Landolfi Nicola Pecile Pantaleone Carlucci Colin Bennett | 29 June 2023 | Reached an altitude of 85.1 km (52.9 mi), crossing the U.S. definition of space. | |||
| — | Frederick Sturckow Kelly Latimer Beth Moses Jon Goodwin  Keisha Schahaff Anastatia Mayers | 10 August 2023 | Reached an altitude of 88.5 km (55.0 mi), crossing the U.S. definition of space. | |||
| 353 | Jasmin Moghbeli  Andreas Mogensen (2) Satoshi Furukawa (2) Konstantin Borisov | 26 August 2023 SpaceX Crew-7, Endurance | ISS (crew 69/70) | 12 March 2024 SpaceX Crew-7, Endurance | ISS crew rotation. | |
| — | Michael Masucci Beth Moses Adrian Reynard [1] Nicola Pecile Ken Baxter [2] /  Timothy Nash [3] | 8 September 2023 | Reached an altitude of 88.56 km (55 mi), crossing the U.S. definition of space. | |||
| 354 | Oleg Kononenko (5) Nikolai Chub | 15 September 2023, Soyuz MS-24 | ISS (69/70/71) | 23 September 2024 Soyuz MS-25 | ISS crew rotation. | |
| Loral O'Hara | ISS (crew 69/70) | 6 April 2024, Soyuz MS-24 | ||||
| — | Frederick Sturckow Kelly Latimer Beth Moses Trevor Beattie  Namira Salim Ron Rosano | 6 October 2023 | Reached an altitude of 87.38 km (54.3 mi), crossing the U.S. definition of space. | |||
| 355 | Tang Hongbo (2) Tang Shengjie Jiang Xinlin | 26 October 2023 Shenzhou 17 | TSS | 30 April 2024 Shenzhou 17 | Sixth crew to Tiangong Space Station. | |
| — | Michael Masucci Kelly Latimer Colin Bennett Alan Stern Kellie Gerardi Ketty Maisonrouge | 2 November 2023 | Reached an altitude of 87.2 km (54.2 mi), crossing the U.S. definition of space. | |||
| 356 | / Michael López-Alegría (6) Walter Villadei  Alper Gezeravcı  /  Marcus Wandt | 18 January 2024, Axiom Mission 3, Freedom | ISS | 09 February 2024, Axiom Mission 3, Freedom | ||
| — | Frederick Sturckow Nicola Pecile / Lina Borozdina Robie Vaughn Franz Haider Neil Kornswiet | 26 January 2024 | Reached an altitude of 88.8 km (55.2 mi), crossing the U.S. definition of space. | |||
| 357 | Matthew Dominick Michael Barratt (3) Jeanette Epps Alexander Grebenkin | 4 March 2024 SpaceX Crew-8, Endeavour | ISS (crew 70/71) | 25 October 2024 SpaceX Crew-8, Endeavour | ISS crew rotation. | |
| 358 | Oleg Novitsky (4) Marina Vasilevskaya | 23 March 2024, Soyuz MS-25 | ISS | 6 April 2024, Soyuz MS-24 | ISS EP-21. | |
| Tracy Caldwell-Dyson (3) | ISS (70/71) | 23 September 2024 Soyuz MS-25 | ISS crew rotation. | |||
| 359 | Ye Guangfu (2) Li Cong Li Guangsu | 25 April 2024 Shenzhou 18 | TSS | in orbit | Seventh crew to Tiangong Space Station. | |
| 360 | Mason Angel Sylvain Chiron Ed Dwight Carol Schaller Kenneth Hess  Thotakura Gopichand | 19 May 2024 | Reached an altitude of 106 km (66 mi), crossing the FAI definition of space. | |||
| 361 | Barry E. Wilmore (3) Sunita Williams (3) | 5 June 2024 Boeing CFT | ISS | in orbit | Crewed Flight Test to International Space Station. | |
| — | Nicola Pecile Jameel Janjua Tuva Cihangir Atasever Giorgio Manenti Irving Pergament Andy Sadhwani | 8 June 2024 | Reached an altitude of 87.5 km (54.4 mi), crossing the U.S. definition of space. | |||
| 362 | /  Nicolina Elrick Karsen Kitchen Rob Ferl Eugene Grin / Eiman Jahangir / Ephraim Rabin | 29 August 2024 | Reached an altitude of 104 km (65 mi), crossing the FAI definition of space. | |||
| 363 | Jared Isaacman (2) Scott Poteet Sarah Gillis Anna Menon | 10 September 2024 Polaris Dawn, Resilience | 15 September 2024 Polaris Dawn, Resilience | |||
| 364 | Aleksey Ovchinin (4) Ivan Vagner (2) Donald Pettit (4) | 11 September 2024, Soyuz MS-26 | ISS (crew 71/72) | in orbit | ISS crew rotation. | |
| 365 | Nick Hague (3) Aleksandr Gorbunov | 28 September 2024 SpaceX Crew-9, Freedom | ISS (crew 72) | in orbit | ISS crew rotation. | |
| 366 | Cai Xuzhe (2) Song Lingdong Wang Haoze | 29 October 2024 Shenzhou 19 | TSS | in orbit | Tiangong Space Station crew rotation. | |
| 367 | James (J.D.) Russell Emily Calandrelli Austin Litteral Marc Hagle (2) Sharon Hagle (2) Henry (Hank) Wolfond | 22 November 2024 | Reached an altitude of 104 km (65 mi), crossing the FAI definition of space. | |||
| 368 | Lane Bess (2) Jesús Calleja Dr. Richard Scott Tushar Shah Elaine Chia Hyde Robert Wilson | 25 February 2025 | Reached an altitude of 107 km (66 mi), crossing the FAI definition of space. | |||
| 369 | Anne McClain (2) Nichole Ayers Takuya Onishi (2) Kirill Peskov | 14 March 2025 SpaceX Crew-10, Endurance | ISS (crew 72/73) | in orbit | ISS crew rotation. | |
