Vaginal estrogen

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Vaginal estrogen is a form of estrogen that is delivered by intravaginal administration. Vaginally administered estrogens are thereby exerting their effects mainly in the nearby tissue, with more limited systemic effects compared to orally administered estrogens. [1] It will not protect against osteoporosis. [2] With perhaps the exception of the Femring, [3] it also will not alleviate the hot flashes and hormonal imbalance caused by menopause. [2]

Contents

Indications

Vaginally administered estrogen are usually used to treat some menopausal symptoms that are isolated to the vagina, vulva and urethra. [4]

Forms

Side effects

Most of the vaginally administered estrogens are synthetic and therefore cause the following side effects [9]

Serious side effects:

Less serious side effects may include: [10]

Contraindications

Estrogen administered vaginally should not be given to persons who are:

Pregnant women

Estrogen should not be used while pregnant as it could cause serious birth defects.

Breastfeeding

Estrogen passes into the breast milk and will cause a decrease in the production and quality of breast milk.

Alternatives

To effectively alleviate the symptoms of menopause, it is best to take oral estrogen instead of topical estrogen since the results are systemic and it will rejuvenate the entire reproductive system and not just the perineal area. [11] [ additional citation(s) needed ]

Phytoestrogens are plant derived compounds found in a wide variety of foods. Several health benefits including a lowered risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms are frequently attributed to phytoestrogens but many are also considered to have the potential to cause adverse health effects. [12] Plants such as Kacip Fatimah have been found to contain phytoestrogens that could alleviate some symptoms of menopause. [13]

See also

References

  1. 1 2 3 Estrogen (Vaginal Route) from Mayo Clinic / Thomson Healthcare Inc. Portions of this document last updated: Nov. 1, 2011
  2. 1 2 "Estrogen (Vaginal Route) Before Using - Mayo Clinic". www.mayoclinic.org. Retrieved 2015-11-18.
  3. 1 2 Smith BT (2014). Pharmacology for Nurses. Jones & Bartlett Publishers. p. 80. ISBN   978-1449689407.
  4. "Estrogen (Vaginal route)". Mmddic/DDIC602127. National Center for Biotechnology Information. 2015-10-01.[ dead link ]
  5. "Estrogen Vaginal Advanced Patient Information - Drugs.com". www.drugs.com. Retrieved 2015-11-18.
  6. Vagifem - Manufacturer's website
  7. Premarin (conjugated estrogens) Vaginal Cream - Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) -- November 2008 [ dead link ]
  8. Moscou K, Snipe K (2014). Pharmacology for Pharmacy Technicians - E-Book. Elsevier Health Sciences. p. 573. ISBN   978-0323292658.
  9. "Side Effects of Premarin Vaginal Cream (Conjugated Estrogens Vaginal Cream) Drug Center - RxList". RxList. Retrieved 2015-11-18.
  10. "Estrogen Vaginal: MedlinePlus Drug Information". www.nlm.nih.gov. Retrieved 2015-11-18.
  11. "Hormone Replacement Therapy". drmarinajohnson.com. Archived from the original on 2017-08-01. Retrieved 2015-11-18.
  12. Patisaul, Heather B.; Jefferson, Wendy (2010-10-01). "The pros and cons of phytoestrogens". Frontiers in Neuroendocrinology. 31 (4): 400–419. doi:10.1016/j.yfrne.2010.03.003. ISSN   0091-3022. PMC   3074428 . PMID   20347861.
  13. Nadia, M. E.; Nazrun, A. S.; Norazlina, M.; Isa, N. M.; Norliza, M.; Ima Nirwana, S. (2012). "The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumilain Prevention of Postmenopausal Osteoporosis". Advances in Pharmacological Sciences. 2012: 1–7. doi: 10.1155/2012/706905 . PMC   3353141 . PMID   22611381.