3-Trifluoromethyl-4-chlorophenylpiperazine

Last updated

TFMCPP
4-Chloro-3-trifluoromethylphenylpiperazine.svg
Clinical data
Other namesTFMCPP; meta-Trifluoromethyl-para-chlorophenylpiperazine; PAL-179; PAL179
Drug class Selective partial serotonin releasing agent
Identifiers
  • 1-[4-chloro-3-(trifluoromethyl)phenyl]piperazine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C11H12ClF3N2
Molar mass 264.68 g·mol−1
3D model (JSmol)
  • C1CN(CCN1)C2=CC(=C(C=C2)Cl)C(F)(F)F
  • InChI=1S/C11H12ClF3N2/c12-10-2-1-8(7-9(10)11(13,14)15)17-5-3-16-4-6-17/h1-2,7,16H,3-6H2
  • Key:SOVLQDJRXJFKHO-UHFFFAOYSA-N

3-Trifluoromethyl-4-chlorophenylpiperazine (TFMCPP; code name PAL-179), or meta-trifluoromethyl-para-chlorophenylpiperazine, is a monoamine releasing agent of the phenylpiperazine family. [1] It acts specifically as a selective partial serotonin releasing agent, with an EC50 Tooltip half-maximal effective concentration of 33 nM and an Emax Tooltip maximal efficacy of 66%. [1] The drug was inactive as a releasing agent of dopamine or norepinephrine (EC50 >10,000 nM). [1] Its possible activity at serotonin receptors was not reported. [1] TFMCPP was first described in the scientific literature by 2012. [1]

Contents

See also

References

  1. 1 2 3 4 5 Rothman RB, Partilla JS, Baumann MH, Lightfoot-Siordia C, Blough BE (April 2012). "Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters". The Journal of Pharmacology and Experimental Therapeutics. 341 (1): 251–262. doi:10.1124/jpet.111.188946. PMC   3364510 . PMID   22271821.
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