CDS2

For the aerodrome using the TC LID, CDS2, see Disley Aerodrome.

CDS2
Identifiers
Aliases	CDS2 , CDP-diacylglycerol synthase 2
External IDs	OMIM: 603549; MGI: 1332236; HomoloGene: 37854; GeneCards: CDS2; OMA:CDS2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p12.3 Start 5,126,879 bp [1] End 5,197,887 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 F2|2 64.15 cM Start 132,105,068 bp [2] End 132,153,970 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus middle temporal gyrus pars compacta pars reticulata postcentral gyrus spinal ganglia entorhinal cortex superior vestibular nucleus external globus pallidus ventral tegmental area Top expressed in motor neuron substantia nigra facial motor nucleus habenula Epithelium of choroid plexus renal corpuscle ciliary body deep cerebellar nuclei medial vestibular nucleus medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity phosphatidate cytidylyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane mitochondrion endoplasmic reticulum membrane mitochondrial inner membrane Biological process phosphatidylglycerol biosynthetic process CDP-diacylglycerol biosynthetic process lipid metabolism phospholipid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8760 110911 Ensembl ENSG00000101290 ENSMUSG00000058793 UniProt O95674 Q99L43 RefSeq (mRNA) NM_003818 NM_001291039 NM_001291040 NM_138651 RefSeq (protein) NP_003809 NP_001277968 NP_001277969 NP_619592 Location (UCSC) Chr 20: 5.13 – 5.2 Mb Chr 2: 132.11 – 132.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidate cytidylyltransferase 2 is an enzyme that in humans is encoded by the CDS2 gene. ^{[5] [6] [7]}

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin. ^{[8] [9]} and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (CDS1) and a second (this gene) to 20p13. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000101290 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058793 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (Nov 1998). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–4. doi:10.1006/geno.1998.5547. PMID   9806839.
6. Volta M, Bulfone A, Gattuso C, Rossi E, Mariani M, Consalez GG, Zuffardi O, Ballabio A, Banfi S, Franco B (Jan 1999). "Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene". Genomics. 55 (1): 68–77. doi:10.1006/geno.1998.5610. PMID   9889000.
7. "Entrez Gene: CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2".
8. Nowicki M, Müller F, Frentzen M (Apr 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–5. doi: 10.1016/j.febslet.2005.03.007 . PMID   15811335. S2CID   21937549.
9. Nowicki M (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. Thesis, RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.
10. "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1".

External links

• Human CDS2 genome location and CDS2 gene details page in the UCSC Genome Browser .

Further reading

• Lykidis A, Jackson PD, Rock CO, Jackowski S (Dec 1997). "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content". The Journal of Biological Chemistry. 272 (52): 33402–9. doi: 10.1074/jbc.272.52.33402 . PMID   9407135.
• Halford S, Inglis S, Gwilliam R, Spencer P, Mohamed M, Ebenezer ND, Hunt DM (Nov 2002). "Genomic organization of human CDS2 and evaluation as a candidate gene for corneal hereditary endothelial dystrophy 2 on chromosome 20p13". Experimental Eye Research. 75 (5): 619–23. doi:10.1006/exer.2002.2052. PMID   12457874.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.