PRSS22

PRSS22
Identifiers
Aliases	PRSS22 , BSSP-4, hBSSP-4, SP001LA, protease, serine 22, serine protease 22
External IDs	OMIM: 609343; MGI: 1918085; HomoloGene: 23344; GeneCards: PRSS22; OMA:PRSS22 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 2,852,730 bp [1] End 2,858,170 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 A3.3|17 12.18 cM Start 24,212,508 bp [2] End 24,217,074 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa minor salivary glands gallbladder body of pancreas right uterine tube prostate tonsil vagina right lobe of thyroid gland left lobe of thyroid gland Top expressed in conjunctival fornix lip transitional epithelium of urinary bladder cornea superior cervical ganglion epithelium of lens external carotid artery esophagus internal carotid artery ciliary body More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type endopeptidase activity hydrolase activity serine-type peptidase activity Cellular component extracellular region extrinsic component of plasma membrane anchored component of plasma membrane Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64063 70835 Ensembl ENSG00000005001 ENSG00000282937 ENSMUSG00000045027 UniProt Q9GZN4 Q9ER10 RefSeq (mRNA) NM_022119 NM_133731 RefSeq (protein) NP_071402 NP_598492 Location (UCSC) Chr 16: 2.85 – 2.86 Mb Chr 17: 24.21 – 24.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene. ^{[5] [6] [7]}

This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. ^[5]

See also

• tryptase

References

1. ENSG00000282937 GRCh38: Ensembl release 89: ENSG00000005001, ENSG00000282937 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045027 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: protease".
6. Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL (December 2001). "Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells". J. Biol. Chem. 276 (52): 49169–82. doi: 10.1074/jbc.M108677200 . PMID   11602603.
7. Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL (May 2005). "Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22". Blood. 105 (10): 3893–901. doi:10.1182/blood-2003-10-3501. PMC   1895090 . PMID   15701722.

Further reading

• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Martin J, Han C, Gordon LA, et al. (2004). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi: 10.1038/nature03187 . PMID   15616553.
• Mitsui S, Okui A, Kominami K, et al. (2005). "A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells". FEBS J. 272 (19): 4911–23. doi: 10.1111/j.1742-4658.2005.04901.x . PMID   16176265. S2CID   25290079.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.