PRSS22

PRSS22
Identifiers
Aliases	PRSS22 , BSSP-4, hBSSP-4, SP001LA, protease, serine 22, serine protease 22
External IDs	OMIM: 609343 MGI: 1918085 HomoloGene: 23344 GeneCards: PRSS22
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,858,170 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,217,074 bp
RNA expression pattern
	Top expressed in
	minor salivary gland; ; gallbladder; ; body of pancreas; ; right uterine tube; ; prostate; ; thymus; ; vagina; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; pituitary gland;
	Top expressed in
	conjunctival fornix; ; lip; ; cornea; ; superior cervical ganglion; ; external carotid artery; ; esophagus; ; internal carotid artery; ; ciliary body; ; trachea; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity ; serine-type endopeptidase activity ; hydrolase activity ; serine-type peptidase activity ;
Cellular component	extracellular region ; extrinsic component of plasma membrane ; anchored component of plasma membrane ;
Biological process	proteolysis ;
	Sources:Amigo / QuickGO
Orthologs
	64063
	70835
	ENSG00000005001 ; ENSG00000282937
	ENSMUSG00000045027
	Q9GZN4
	Q9ER10
	NM_022119
	NM_133731
	NP_071402
	NP_598492
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene.^[5]^[6]^[7]

Related Research Articles

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<span class="mw-page-title-main">Kallikrein-5</span> Protein-coding gene in the species Homo sapiens

Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.

Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. The HTRA1 protein is composed of four distinct protein domains. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kazal domain, a trypsin-like peptidase domain and a PDZ domain.

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.

Kunitz-type protease inhibitor 1 is an enzyme that in humans is encoded by the SPINT1 gene.

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.

Cathepsin L2,, is a protein encoded in humans by the CTSV gene.

Serine protease 23 is an enzyme that in humans is encoded by the PRSS23 gene.

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.

Granzyme H is a protein that in humans is encoded by the GZMH gene.

Granzyme M is a protein that in humans is encoded by the GZMM gene.

Tryptase delta is an enzyme that in humans is encoded by the TPSD1 gene.

Eppin is a protein that in humans is encoded by the SPINLW1 gene.

Thymus-specific serine protease is an enzyme that in humans is encoded by the PRSS16 gene.

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1. Serpin A9 is a member of the serpin family of serine protease inhibitors.

Chymotrypsin C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene.

Tryptase beta-2, also known as tryptase II, is an enzyme that in humans is encoded by the TPSB2 gene.

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References

1 2 3 ENSG00000282937 GRCh38: Ensembl release 89: ENSG00000005001, ENSG00000282937 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045027 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: protease".
↑ Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL (December 2001). "Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells". J. Biol. Chem. 276 (52): 49169–82. doi: 10.1074/jbc.M108677200 . PMID 11602603.
↑ Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL (May 2005). "Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22". Blood. 105 (10): 3893–901. doi:10.1182/blood-2003-10-3501. PMC 1895090 . PMID 15701722.

Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Martin J, Han C, Gordon LA, et al. (2004). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi: 10.1038/nature03187 . PMID 15616553.
Mitsui S, Okui A, Kominami K, et al. (2005). "A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells". FEBS J. 272 (19): 4911–23. doi: 10.1111/j.1742-4658.2005.04901.x . PMID 16176265. S2CID 25290079.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000282937 GRCh38: Ensembl release 89: ENSG00000005001, ENSG00000282937 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045027 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: protease".

[pmid11602603-6] Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL (December 2001). "Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells". J. Biol. Chem. 276 (52): 49169–82. doi: 10.1074/jbc.M108677200 . PMID 11602603.

[pmid15701722-7] Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL (May 2005). "Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22". Blood. 105 (10): 3893–901. doi:10.1182/blood-2003-10-3501. PMC 1895090 . PMID 15701722.

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v t e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PRSS22

Contents

See also

Related Research Articles

References

Further reading