|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
In enzymology, a thymidine-triphosphatase (EC 188.8.131.52) is an enzyme that catalyzes the chemical reaction
The Enzyme Commission number is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. As a system of enzyme nomenclature, every EC number is associated with a recommended name for the respective enzyme.
Catalysis is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst, which is not consumed in the catalyzed reaction and can continue to act repeatedly. Because of this, only very small amounts of catalyst are required to alter the reaction rate in principle.
A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and breaking of chemical bonds between atoms, with no change to the nuclei, and can often be described by a chemical equation. Nuclear chemistry is a sub-discipline of chemistry that involves the chemical reactions of unstable and radioactive elements where both electronic and nuclear changes can occur.
Thus, the two substrates of this enzyme are dTTP and H2O, whereas its two products are dTDP and phosphate.
Water is a transparent, tasteless, odorless, and nearly colorless chemical substance, which is the main constituent of Earth's streams, lakes, and oceans, and the fluids of most living organisms. It is vital for all known forms of life, even though it provides no calories or organic nutrients. Its chemical formula is H2O, meaning that each of its molecules contains one oxygen and two hydrogen atoms, connected by covalent bonds. Water is the name of the liquid state of H2O at standard ambient temperature and pressure. It forms precipitation in the form of rain and aerosols in the form of fog. Clouds are formed from suspended droplets of water and ice, its solid state. When finely divided, crystalline ice may precipitate in the form of snow. The gaseous state of water is steam or water vapor. Water moves continually through the water cycle of evaporation, transpiration (evapotranspiration), condensation, precipitation, and runoff, usually reaching the sea.
Products are the species formed from chemical reactions. During a chemical reaction reactants are transformed into products after passing through a high energy transition state. This process results in the consumption of the reactants. It can be a spontaneous reaction or mediated by catalysts which lower the energy of the transition state, and by solvents which provide the chemical environment necessary for the reaction to take place. When represented in chemical equations products are by convention drawn on the right-hand side, even in the case of reversible reactions. The properties of products such as their energies help determine several characteristics of a chemical reaction such as whether the reaction is exergonic or endergonic. Additionally the properties of a product can make it easier to extract and purify following a chemical reaction, especially if the product has a different state of matter than the reactants. Reactants are molecular materials used to create chemical reactions. The atoms aren't created or destroyed. The materials are reactive and reactants are rearranging during a chemical reaction. Here is an example of reactants: CH4 + O2. A non-example is CO2 + H2O or "energy".
A Phosphate is a chemical derivative of phosphoric acid. The phosphate ion (PO
is an inorganic chemical, the conjugate base that can form many different salts. In organic chemistry, a phosphate, or organophosphate, is an ester of phosphoric acid. Of the various phosphoric acids and phosphates, organic phosphates are important in biochemistry and biogeochemistry, and inorganic phosphates are mined to obtain phosphorus for use in agriculture and industry. At elevated temperatures in the solid state, phosphates can condense to form pyrophosphates.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dTTP nucleotidohydrolase. Other names in common use include thymidine triphosphate nucleotidohydrolase, dTTPase, and deoxythymidine-5'-triphosphatase. This enzyme participates in pyrimidine metabolism.
Hydrolase is a class of enzyme that commonly perform as biochemical catalysts that use water to break a chemical bond, which typically results in dividing a larger molecule to smaller molecules. Some common examples of hydrolase enzymes are esterases including lipases, phosphatases, glycosidases, peptidases, and nucleosidases.
Pyrimidine biosynthesis occurs both in the body and through organic synthesis.
A salvage pathway is a pathway in which nucleotides are synthesized from intermediates in the degradative pathway for nucleotides.
In enzymology, a bis(5'-adenosyl)-triphosphatase (EC 184.108.40.206) is an enzyme that catalyzes the chemical reaction
In enzymology, a bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (EC 220.127.116.11) is an enzyme that catalyzes the chemical reaction
In enzymology, a dCTP diphosphatase (EC 18.104.22.168) is an enzyme that catalyzes the chemical reaction
In enzymology, a dUTP diphosphatase (EC 22.214.171.124) is an enzyme that catalyzes the chemical reaction
In enzymology, a guanosine-5'-triphosphate,3'-diphosphate diphosphatase (EC 126.96.36.199) is an enzyme that catalyzes the chemical reaction
In enzymology, a nucleoside-diphosphatase (EC 188.8.131.52) is an enzyme that catalyzes the chemical reaction
In enzymology, a nucleoside-triphosphatase(NTPase) (EC 184.108.40.206) is an enzyme that catalyzes the chemical reaction
Thiamine-triphosphatase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction
In enzymology, a triphosphatase (EC 220.127.116.11) is an enzyme that catalyzes the chemical reaction
In enzymology, a dTDP-4-amino-4,6-dideoxy-D-glucose transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a dTDP-4-amino-4,6-dideoxygalactose transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a dTMP kinase is an enzyme that catalyzes the chemical reaction
In enzymology, a galactose-1-phosphate thymidylyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a glucose-1-phosphate thymidylyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a thiamine-diphosphate kinase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction
Thymidine diphosphate glucose is a nucleotide-linked sugar consisting of deoxythymidine diphosphate linked to glucose. It is the starting compound for the syntheses of many deoxysugars.
Thymidylate kinase catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:
DTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase. This enzyme catalyses the following chemical reaction
DTDP-dihydrostreptose---streptidine-6-phosphate dihydrostreptosyltransferase is an enzyme with systematic name dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase. This enzyme catalyses the following chemical reaction
In computing, a digital object identifier (DOI) is a persistent identifier or handle used to identify objects uniquely, standardized by the International Organization for Standardization (ISO). An implementation of the Handle System, DOIs are in wide use mainly to identify academic, professional, and government information, such as journal articles, research reports and data sets, and official publications though they also have been used to identify other types of information resources, such as commercial videos.
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