Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

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bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
Identifiers
EC no. 3.6.1.17
CAS no. 37289-29-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, a bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (EC 3.6.1.17) is an enzyme that catalyzes the chemical reaction

P1,P4-bis(5'-guanosyl) tetraphosphate + H2O GTP + GMP

Thus, the two substrates of this enzyme are P1,P4-bis(5'-guanosyl) tetraphosphate and H2O, whereas its two products are GTP and GMP.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase. Other names in common use include bis(5'-guanosyl)-tetraphosphatase, bis(5'-adenosyl)-tetraphosphatase, diguanosinetetraphosphatase (asymmetrical), dinucleosidetetraphosphatase (asymmetrical), diadenosine P1,P4-tetraphosphatase, dinucleoside tetraphosphatase, and 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase. This enzyme participates in purine metabolism and pyrimidine metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1F3Y, 1JKN, 1KT9, 1KTG, 1XSA, 1XSB, and 1XSC.

Related Research Articles

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References


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