Diadenosine hexaphosphate hydrolase (ATP-forming)

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Diadenosine hexaphosphate hydrolase (ATP-forming)
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EC no. 3.6.1.61
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Diadenosine hexaphosphate hydrolase (ATP-forming) (EC 3.6.1.61, Ndx1) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming). [1] This enzyme catalyses the following chemical reaction

(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O 2 ATP
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O ATP + ADP
(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O ATP + AMP

The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+).

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<span class="mw-page-title-main">NUDT2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Cobalamin biosynthesis</span>

Cobalamin biosynthesis is the process by which bacteria and archea make cobalamin, vitamin B12. Many steps are involved in converting aminolevulinic acid via uroporphyrinogen III and adenosylcobyric acid to the final forms in which it is used by enzymes in both the producing organisms and other species, including humans who acquire it through their diet.

Diadenosine hexaphosphate hydrolase (AMP-forming) (EC 3.6.1.60, hAps1, NUDT11 (gene), hAps2, NUDT10 (gene)) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming). This enzyme catalyses the following chemical reaction

References

  1. ↑ Iwai T, Kuramitsu S, Masui R (May 2004). "The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity". The Journal of Biological Chemistry. 279 (21): 21732–9. doi: 10.1074/jbc.m312018200 . PMID   15024014.
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