| m7G(5')pppN diphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.6.1.59 | ||||||||
| CAS no. | 82599-75-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a m7G(5')pppN diphosphatase or m7G(5')pppN pyrophosphatase (EC 3.6.1.59) is an enzyme that catalyzes the chemical reaction
- 7-methylguanosine 5'-triphospho-5'-polyribonucleotide + H2O 7-methylguanosine 5'-phosphate + 5'-diphospho-polyribonucleotide
Thus, the two substrates of this enzyme are 7-methylguanosine 5'-triphospho-5'-polynucleotide and H2O, whereas its two products are 7-methylguanosine 5'-phosphate and 5'-diphospho-polyribonucleotide. [1] [2] [3]
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase.
Another name in common use is decapase because this enzyme removes the N7-methylguanosine 5-phosphate cap from an mRNA. The process of mRNA decapping controls eukaryotic mRNA degradation. [4]
This is the enzyme involved in the processing of amphetamines of the cathinone group, including mephedrone and khat.
