M7G(5')pppN diphosphatase

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m7G(5')pppN diphosphatase
Identifiers
EC no. 3.6.1.30
CAS no. 82599-75-5
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In enzymology, a m7G(5')pppN diphosphatase (EC 3.6.1.30) is an enzyme that catalyzes the chemical reaction

7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O 7-methylguanosine 5'-phosphate + polynucleotide

Thus, the two substrates of this enzyme are 7-methylguanosine 5'-triphospho-5'-polynucleotide and H2O, whereas its two products are 7-methylguanosine 5'-phosphate and polynucleotide.

This is the enzyme involved in the processing of amphetamines of the cathinone group, including mephedrone and khat.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase. Other names in common use include decapase, and m7G(5')pppN pyrophosphatase.

See also

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M7GpppX diphosphatase (EC 3.6.1.59, DcpS, m7GpppX pyrophosphatase, m7GpppN m7GMP phosphohydrolase) is an enzyme with systematic name m7G5'ppp5'N m7GMP phosphohydrolase. This enzyme catalyses the following chemical reaction

References


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