M7GpppX diphosphatase

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M7GpppX diphosphatase
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EC no. 3.6.1.59
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M7GpppX diphosphatase (EC 3.6.1.59, DcpS, m7GpppX pyrophosphatase, m7GpppN m7GMP phosphohydrolase) is an enzyme with systematic name m7G5'ppp5'N m7GMP phosphohydrolase. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

(1) m7G5'ppp5'N(3'ppp5'N)n + H2O 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
(2) 7-methylguanosine 5'-diphosphate + H2O 7-methylguanosine 5'-phosphate + phosphate

Decapping is a process in the control of eukaryotic mRNA degradation.

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In enzymology, a m7G(5')pppN diphosphatase (EC 3.6.1.30) is an enzyme that catalyzes the chemical reaction

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<span class="mw-page-title-main">Nucleoside-diphosphatase</span> Group of proteins having nucleoside-diphosphatase activity

In enzymology, a nucleoside-diphosphatase (EC 3.6.1.6) is an enzyme that catalyzes the chemical reaction

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In enzymology, an undecaprenyl-diphosphatase (EC 3.6.1.27) is an enzyme that catalyzes the chemical reaction

The enzyme guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase (EC 3.1.7.2) catalyzes the reaction

The enzyme polynucleotide 5′-phosphatase (RNA 5′-triphosphatase, RTPase, EC 3.1.3.33) is an enzyme that catalyzes the reaction

<span class="mw-page-title-main">DCP2</span> Protein found in humans

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.

<span class="mw-page-title-main">DCPS (gene)</span> Protein-coding gene in the species Homo sapiens

Scavenger mRNA-decapping enzyme DcpS is a protein that in humans is encoded by the DCPS gene.

<span class="mw-page-title-main">Decapping complex</span> Eukaryotic protein complex that removes the 5 cap on mRNA

The mRNA decapping complex is a protein complex in eukaryotic cells responsible for removal of the 5' cap. The active enzyme of the decapping complex is the bilobed Nudix family enzyme Dcp2, which hydrolyzes 5' cap and releases 7mGDP and a 5'-monophosphorylated mRNA. This decapped mRNA is inhibited for translation and will be degraded by exonucleases. The core decapping complex is conserved in eukaryotes. Dcp2 is activated by Decapping Protein 1 (Dcp1) and in higher eukaryotes joined by the scaffold protein VCS. Together with many other accessory proteins, the decapping complex assembles in P-bodies in the cytoplasm.

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase (EC 3.1.3.87, HK-MTPenyl-1-P phosphatase, MtnX, YkrX) is an enzyme with systematic name 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate phosphohydrolase. This enzyme catalyses the following chemical reaction

Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.53, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, ADPRibase-Mn) is an enzyme with systematic name CDP-choline phosphohydrolase. This enzyme catalyses the following chemical reaction

UDP-2,3-diacylglucosamine diphosphatase (EC 3.6.1.54, UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine pyrophosphatase, ybbF (gene), lpxH (gene)) is an enzyme with systematic name UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate phosphohydrolase. This enzyme catalyses the following chemical reaction

M7GpppN-mRNA hydrolase (EC 3.6.1.62, DCP2, NUDT16, D10 protein, D9 protein, D10 decapping enzyme, decapping enzyme) is an enzyme with systematic name m7GpppN-mRNA m7GDP phosphohydrolase. This enzyme catalyses the following chemical reaction

References

  1. ↑ Malys N, McCarthy JE (October 2006). "Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies". Journal of Molecular Biology. 363 (2): 370–82. doi:10.1016/j.jmb.2006.08.015. PMID   16963086.
  2. ↑ Liu SW, Rajagopal V, Patel SS, Kiledjian M (June 2008). "Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme". The Journal of Biological Chemistry. 283 (24): 16427–36. doi: 10.1074/jbc.M800341200 . PMC   2423256 . PMID   18441014.
  3. ↑ Liu H, Rodgers ND, Jiao X, Kiledjian M (September 2002). "The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases". The EMBO Journal. 21 (17): 4699–708. doi:10.1093/emboj/cdf448. PMC   126188 . PMID   12198172.
  4. ↑ van Dijk E, Le Hir H, Séraphin B (October 2003). "DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12081–6. Bibcode:2003PNAS..10012081V. doi: 10.1073/pnas.1635192100 . PMC   218716 . PMID   14523240.
  5. ↑ Chen N, Walsh MA, Liu Y, Parker R, Song H (April 2005). "Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping". Journal of Molecular Biology. 347 (4): 707–18. doi:10.1016/j.jmb.2005.01.062. PMID   15769464.
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