SPHK2

Last updated
SPHK2
Identifiers
Aliases SPHK2 , SK 2, SK-2, SPK 2, SPK-2, sphingosine kinase 2
External IDs OMIM: 607092 MGI: 1861380 HomoloGene: 32456 GeneCards: SPHK2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204158
NM_001204159
NM_001204160
NM_001243876
NM_020126

Contents

NM_001172561
NM_020011
NM_203280

RefSeq (protein)

NP_001191087
NP_001191088
NP_001191089
NP_001230805
NP_064511

NP_001166032
NP_064395
NP_975009

Location (UCSC) Chr 19: 48.62 – 48.63 Mb Chr 7: 45.36 – 45.37 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene. [5]

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [5] [6]

The researchers also found that the expression of sphingosine kinase 2 (SphK2) and the secretion of sphingosine-1-phosphate (S1P) were significantly upregulated in the lungs of CS-exposed mice with COPD-like symptoms. [7]

Inhibitors

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000063176 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057342 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: Sphingosine kinase 2" . Retrieved 2011-12-22.
  6. [provided by RefSeq, Aug 2011].
  7. Chen Y, Zhang Y, Rao C, Huang J, Qing Q (2023-03-16). "Deletion of sphingosine kinase 2 attenuates cigarette smoke-mediated chronic obstructive pulmonary disease-like symptoms by reducing lung inflammation". Biomolecules and Biomedicine. 23 (2): 259–270. doi:10.17305/bjbms.2022.8034. ISSN   2831-090X. PMC   10113950 . PMID   36226596.

Further reading