Alkylglycerophosphoethanolamine phosphodiesterase

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alkylglycerophosphoethanolamine phosphodiesterase
Identifiers
EC no. 3.1.4.39
CAS no. 62213-15-4
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MetaCyc metabolic pathway
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The enzyme alkylglycerophosphoethanolamine phosphodiesterase (EC 3.1.4.39) catalyzes the reaction

1-alkyl-sn-glycero-3-phosphoethanolamine + H2O 1-alkyl-sn-glycerol 3-phosphate + ethanolamine

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is 1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase. This enzyme is also called lysophospholipase D. This enzyme participates in ether lipid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1FJ2.

Related Research Articles

<span class="mw-page-title-main">Phospholipase</span> Class of enzymes that cleave phospholipids

A phospholipase is an enzyme that hydrolyzes phospholipids into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C, and D, which are distinguished by the type of reaction which they catalyze:

<span class="mw-page-title-main">Glycerophospholipid</span> Class of lipids

Glycerophospholipids or phosphoglycerides are glycerol-based phospholipids. They are the main component of biological membranes in eukaryotic cells. They are a type of lipid, of which its composition affects membrane structure and properties. Two major classes are known: those for bacteria and eukaryotes and a separate family for archaea.

<span class="mw-page-title-main">Ether lipid</span>

In biochemistry, an ether lipid refers to any lipid in which the lipid "tail" group is attached to the glycerol backbone via an ether bond at any position. In contrast, conventional glycerophospholipids and triglycerides are triesters. Structural types include:

In enzymology, a phosphatidylcholine desaturase (EC 1.14.19.22, previously EC 1.3.1.35) is an enzyme that catalyzes the chemical reaction

In enzymology, a plasmanylethanolamine desaturase (EC 1.14.99.19) is an enzyme that catalyzes the chemical reaction

In enzymology, an alkenylglycerophosphocholine hydrolase (EC 3.3.2.2) is an enzyme that catalyzes the chemical reaction

In enzymology, an alkenylglycerophosphoethanolamine hydrolase (EC 3.3.2.5) is an enzyme that catalyzes the chemical reaction

The enzyme 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) catalyzes the reaction

The enzyme alkylacetylglycerophosphatase (EC 3.1.3.59) catalyzes the reaction

In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a 1-alkyl-2-acetylglycerol O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a 1-alkylglycerophosphocholine O-acetyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a 1-alkylglycerophosphocholine O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an alkylglycerophosphate 2-O-acetyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glycerophospholipid acyltransferase (CoA-dependent) is an enzyme that catalyzes the chemical reaction

In the field of enzymology, a glycerophospholipid arachidonoyl-transferase (CoA-independent) is an enzyme that catalyzes the chemical reaction:

In enzymology, an alkylglycerol kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Diacylglycerol cholinephosphotransferase</span>

In enzymology, a diacylglycerol cholinephosphotransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">1-Lysophosphatidylcholine</span>

1-Lysophosphatidylcholines are a class of phospholipids that are intermediates in the metabolism of lipids. They result from the hydrolysis of an acyl group from the sn-1 position of phosphatidylcholine. They are also called 2-acyl-sn-glycero-3-phosphocholines. The synthesis of phosphatidylcholines with specific fatty acids occurs through the synthesis of 1-lysoPC. The formation of various other lipids generates 1-lysoPC as a by-product.

Lipid A phosphoethanolamine transferase is an enzyme that modifies Lipid A by linkage to a phosphoethanolamine moiety. Doing so at some positions reduces the affinity to colistin and related polymyxins, resulting in reduced activity of the antimicrobial. This type of resistance is known as target modification. This type of enzyme is of special medical note, as it offers resistance to a last-resort antibiotic. The modifications also provide cross-resistance to host immunity factors, specifically antimicrobial peptides and lysozyme. EC 2.7.8.43 catalyzes one of the following three reactions:

References


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