Hydroxybutyrate-dimer hydrolase

Last updated
hydroxybutyrate-dimer hydrolase
Identifiers
EC no. 3.1.1.22
CAS no. 37278-37-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

The enzyme hydroxybutyrate-dimer hydrolase (EC 3.1.1.22) catalyzes the reaction

(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O 2 (R)-3-hydroxybutanoate

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is (R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase. The enzyme is also called D-(–)-3-hydroxybutyrate-dimer hydrolase. It participates in butanoate metabolism.

Related Research Articles

Hydrolase is a class of enzymes that commonly perform as biochemical catalysts that use water to break a chemical bond, which typically results in dividing a larger molecule into smaller molecules. Some common examples of hydrolase enzymes are esterases including lipases, phosphatases, glycosidases, peptidases, and nucleosidases.

β-Hydroxybutyric acid Chemical compound

β-Hydroxybutyric acid, also known as 3-hydroxybutyric acid or BHB, is an organic compound and a beta hydroxy acid with the chemical formula CH3CH(OH)CH2CO2H; its conjugate base is β-hydroxybutyrate, also known as 3-hydroxybutyrate. β-Hydroxybutyric acid is a chiral compound with two enantiomers: D-β-hydroxybutyric acid and L-β-hydroxybutyric acid. Its oxidized and polymeric derivatives occur widely in nature. In humans, D-β-hydroxybutyric acid is one of two primary endogenous agonists of hydroxycarboxylic acid receptor 2 (HCA2), a Gi/o-coupled G protein-coupled receptor (GPCR).

<span class="mw-page-title-main">Glycoside hydrolase</span> Enzyme

Glycoside hydrolases catalyze the hydrolysis of glycosidic bonds in complex sugars. They are extremely common enzymes with roles in nature including degradation of biomass such as cellulose (cellulase), hemicellulose, and starch (amylase), in anti-bacterial defense strategies, in pathogenesis mechanisms and in normal cellular function. Together with glycosyltransferases, glycosidases form the major catalytic machinery for the synthesis and breakage of glycosidic bonds.

Paenarthrobacter ureafaciens KI72, popularly known as nylon-eating bacteria, is a strain of Paenarthrobacter ureafaciens that can digest certain by-products of nylon 6 manufacture. It uses a set of enzymes to digest nylon, popularly known as nylonase.

Paucimonas lemoignei, formerly [Pseudomonas lemoignei], is a Gram-negative soil bacterium. It is aerobic, motile, and rod-shaped.

<span class="mw-page-title-main">4-Hydroxybutyrate dehydrogenase</span> Class of enzymes

In enzymology, a 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) is an enzyme that catalyzes the chemical reaction

In enzymology, a D-malate dehydrogenase (decarboxylating) (EC 1.1.1.83) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">3-hydroxyacyl-CoA dehydrogenase</span> Enzyme

In enzymology, a 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) is an enzyme that catalyzes the chemical reaction

In enzymology, 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) is an enzyme that catalyzes the chemical reaction:

In enzymology, a beta-diketone hydrolase (EC 3.7.1.7) is an enzyme that catalyzes the chemical reaction

The enzyme acetolactate decarboxylase (EC 4.1.1.5) catalyzes the chemical reaction

<span class="mw-page-title-main">3-hydroxybutyryl-CoA dehydratase</span> Class of enzymes

The enzyme 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) catalyzes the chemical reaction

The enzyme acetoacetyl-CoA hydrolase (EC 3.1.2.11) catalyzes the reaction

The enzyme phorbol-diester hydrolase (EC 3.1.1.51) catalyzes the reaction

Poly(3-hydroxybutyrate) depolymerase (EC 3.1.1.75, PHB depolymerase, systematic name poly[(R)-3-hydroxybutanoate] hydrolase) is an enzyme used in the degradation processes of a natural polyester poly(3-hydroxyburate). This enzyme has growing commercialization interests due to it implications in biodegradable plastic decomposition.

In enzymology, a 6-aminohexanoate-cyclic-dimer hydrolase (EC 3.5.2.12) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">6-aminohexanoate-dimer hydrolase</span> Class of enzymes

In enzymology, a 6-aminohexanoate-dimer hydrolase (EC 3.5.1.46) is an enzyme that catalyzes the chemical reaction N-(6-aminohexanoyl)-6-aminohexanoate + H2O 2 6-aminohexanoate. Thus, the two substrates of this enzyme are N-(6-aminohexanoyl)-6-aminohexanoate and H2O, whereas its product is two molecules of 6-aminohexanoate.

In enzymology, a gamma-glutamyl-gamma-aminobutyrate hydrolase (EC 3.5.1.94) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Formylmethanofuran—tetrahydromethanopterin N-formyltransferase</span>

In enzymology, a formylmethanofuran-tetrahydromethanopterin N-formyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">BDH1</span> Protein-coding gene in the species Homo sapiens

D-beta-hydroxybutyrate dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the BDH1 gene.

References