Inositol-1,4-bisphosphate 1-phosphatase

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inositol-1,4-bisphosphate 1-phosphatase
Identifiers
EC no. 3.1.3.57
CAS no. 111070-17-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

The enzyme inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) catalyzes the reaction

1D-myo-inositol 1,4-bisphosphate + H2O 1D-myo-inositol 4-phosphate + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase. This enzyme is also called inositol-polyphosphate 1-phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1INP and 1JP4.

Related Research Articles

<span class="mw-page-title-main">Inositol-3-phosphate synthase</span>

In enzymology, an inositol-3-phosphate synthase is an enzyme that catalyzes the chemical reaction

The enzyme glycosylphosphatidylinositol diacylglycerol-lyase catalyzes the reaction

<span class="mw-page-title-main">3'(2'),5'-bisphosphate nucleotidase</span> Class of enzymes

The enzyme 3′(2′),5′-bisphosphate nucleotidase (EC 3.1.3.7) catalyzes the reaction

The enzyme glycerophosphoinositol inositolphosphodiesterase (EC 3.1.4.43) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Inositol-phosphate phosphatase</span> Class of enzymes

The enzyme Inositol phosphate-phosphatase is of the phosphodiesterase family of enzymes. It is involved in the phosphophatidylinositol signaling pathway, which affects a wide array of cell functions, including but not limited to, cell growth, apoptosis, secretion, and information processing. Inhibition of inositol monophosphatase may be key in the action of lithium in treating bipolar disorder, specifically manic depression.

The enzyme multiple inositol-polyphosphate phosphatase (EC 3.1.3.62) catalyzes the reaction

The enzyme phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) catalyzes the chemical reaction

The enzyme phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) that catalyzes the reaction

The enzyme phosphatidylinositol-3-phosphatase (EC 3.1.3.64) catalyzes the reaction

The enzyme phosphoinositide 5-phosphatase (EC 3.1.3.36) catalyzes the reaction

<span class="mw-page-title-main">1-phosphatidylinositol 4-kinase</span> Class of enzymes

In enzymology, a 1-phosphatidylinositol 4-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, an inositol-tetrakisphosphate 1-kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">INPP4A</span> Protein-coding gene in the species Homo sapiens

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.

<span class="mw-page-title-main">INPP5B</span> Protein-coding gene in the species Homo sapiens

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.

<span class="mw-page-title-main">INPP5A</span> Protein-coding gene in the species Homo sapiens

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.

<span class="mw-page-title-main">INPP1</span> Protein-coding gene in the species Homo sapiens

Inositol polyphosphate 1-phosphatase is an enzyme that, in humans, is encoded by the INPP1 gene. INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.

<span class="mw-page-title-main">INPP4B</span> Protein-coding gene in the species Homo sapiens

Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.

The enzyme inositol-polyphosphate 5-phosphatase (EC 3.1.3.56), systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase, catalyses the following reactions:

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P2 4-Ptase, type II PtdIns-4,5-P2 4-Ptase, IpgD, PtdIns-4,5-P2 4-phosphatase type I, PtdIns-4,5-P2 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase. This enzyme catalyses the following chemical reaction

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase, that has two isoforms: SHIP1 and SHIP2 (INPPL1).

References