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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.017.990 |
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| Formula | C17H23N3O |
| Molar mass | 285.391 g·mol−1 |
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Piperylone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties. [1]
Hydrazone formation of 1-methyl-4-piperidone (1) with benzohydrazide (2) gives (3). Catalytic hydrogenation using Adams' catalyst gives the substituted hydrazine (6) after acid-catalyzed hydrolysis to remove the benzoyl group and neutralization. The pyrazolone ring is formed in a condensation reaction with ethyl 2-benzoylbutanoate (7), yielding piperylone. [2] [3] [4]
In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of one or more hydroxyl groups (−OH) bonded directly to an aromatic hydrocarbon group. The simplest is phenol, C
6H
5OH. Phenolic compounds are classified as simple phenols or polyphenols based on the number of phenol units in the molecule.
Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring. It is also known as E number E102, C.I. 19140, FD&C Yellow 5, Yellow 5 Lake, Acid Yellow 23, Food Yellow 4, and trisodium 1-(4-sulfonatophenyl)-4-(4-sulfonatophenylazo)-5-pyrazolone-3-carboxylate.
Curling at the 2006 Winter Olympics was held in the town of Pinerolo, Italy from February 13 to February 24. It proved to be the sleeper hit in terms of television ratings in Italy. According to a CBC feature, curling at the 2006 Winter Games drew 5 million viewers, eclipsing ice hockey and figure skating. This, and the success of the Italian men's curling team created a surge of interest in curling within Italy, where there was no previous tradition of the sport and only a few hundred players.
Edwin Louis Jucker was an American basketball and baseball coach and college athletics administrator. He served as the head basketball coach at the United States Merchant Marine Academy from 1945 to 1948, Rensselaer Polytechnic Institute (RPI) from 1948 to 1953, the University of Cincinnati from 1960 to 1965, and Rollins College from 1972 to 1977, compiling a career college basketball coaching record of 270–122. He led the Cincinnati Bearcats men's basketball program to consecutive national titles, winning the NCAA basketball tournament in 1961 and 1962. Jucker was also the head coach of the Cincinnati Bearcats baseball team from 1954 to 1960 while serving as an assistant coach for the basketball team. He spent two seasons coaching in the professional ranks, leading the Cincinnati Royals of the National Basketball Association (NBA) from 1967 to 1969. Jucker served as the athletic director at Rollins College from 1981 to 1983.
Amyloid plaques are extracellular deposits of the amyloid beta (Aβ) protein mainly in the grey matter of the brain. Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques. Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400-450 square micrometers (μm2). The smallest plaques, which often consist of diffuse deposits of Aβ, are particularly numerous. Plaques form when Aβ misfolds and aggregates into oligomers and longer polymers, the latter of which are characteristic of amyloid.
Oxybuprocaine (INN), also known as benoxinate or BNX, is an ester-type local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine is sold by Novartis under the brand names Novesine or Novesin.
Pyrazolone is 5-membered heterocycle containing two adjacent nitrogen atoms. It can be viewed as a derivative of pyrazole possessing an additional carbonyl (C=O) group. Compounds containing this functional group are useful commercially in analgesics and dyes.
Seegräben is a village and a municipality in the district of Hinwil in the canton of Zürich in Switzerland. Besides the village of Seegräben itself, the municipality also includes the settlements of Aathal, Aathal-Seegräben, Aretshalden, Ottenhausen, Sack and Wagenburg.
Propyphenazone is a derivative of phenazone with similar analgesic and antipyretic effects. Originally patented in 1931, propyphenazone is marketed as a combination formulation with paracetamol and caffeine for treatment of primary headache disorder.
The 2004 Continental Cup of Curling was held in Medicine Hat, Alberta from November 25 to 28. North America won its second title, defeating Team Europe 228–172.
Dilazep is a vasodilator that acts as an adenosine reuptake inhibitor.
Thioproperazine, sold under the brand name Majeptil, is a typical antipsychotic of the phenothiazine group which is used as a tranquilizer, antiemetic, sedative, and in the treatment of schizophrenia and manic phase of bipolar disorder. Majeptil is available in 10 mg tablets.
Dimethisterone, formerly sold under the brand names Lutagan and Secrosteron among others, is a progestin medication which was used in birth control pills and in the treatment of gynecological disorders but is now no longer available. It was used both alone and in combination with an estrogen. It is taken by mouth.
Noxiptiline, also known as noxiptyline and dibenzoxine, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1970s for the treatment of depression. It has imipramine-like effects, acting as a serotonin and norepinephrine reuptake inhibitor, among other properties. Of the TCAs, noxiptiline has been described as one of the most effective, rivaling amitriptyline in clinical efficacy.
Alan Ebnother is a contemporary American artist. His practice as an artist is usually associated with monochrome, concrete, modernist, post, color-based, radical, minimalist, and abstract painting.
Morazone is a nonsteroidal anti-inflammatory drug (NSAID), originally developed by the German pharmaceutical company Ravensberg in the 1950s, which is used as an analgesic. It produces phenmetrazine as a major metabolite and has been reported to have been abused as a recreational drug in the past.
Famprofazone is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan. It has analgesic, anti-inflammatory, and antipyretic effects. Famprofazone has been known to produce methamphetamine as an active metabolite, with 15–20% of an oral dose being converted to it. As a result, famprofazone has occasionally been implicated in causing positives on drug tests for amphetamines.
The Keg 2002 Continental Cup of Curling was held at the Agridome in Regina, Saskatchewan November 7–10. It was the very first edition of the event. North America defeated their European counterparts 207-193. Despite the fact that all the teams were from Europe, North America's opposition was known as Team World. Later events would name the team "Team Europe" until 2008, when "Team World" was re-adopted after the inclusion of Chinese teams.
Estradiol undecylenate is an estrogen medication and estrogen ester which was never marketed. It is the C17β undecenoate (undecylenate) ester of estradiol. Following an intramuscular injection, EUe has a very prolonged effect, exceeding that of other estradiol esters like estradiol valerate and estradiol enanthate. Due to its very long duration of action, EUe releases only subthreshold amounts of estradiol at conventional doses. However, this may still be useful in menopausal hormone therapy.
Jucker, also known as Juckerspiel or Juckern, is a card game that was popular in the Alsace and Palatinate regions on either side of the modern Franco-German border. It is believed to be the ancestor of Euchre and may have given its name to the playing card known as the Joker.
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