Diacylglycerol diphosphate phosphatase

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Diacylglycerol diphosphate phosphatase
Identifiers
EC no. 3.1.3.81
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Diacylglycerol diphosphate phosphatase (EC 3.1.3.81, DGPP phosphatase, DGPP phosphohydrolase, DPP1, DPPL1, DPPL2, PAP2, pyrophosphate phosphatase) is an enzyme with systematic name 1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase. [1] [2] [3] [4] [5] [6] This enzyme catalyses the following chemical reaction

1,2-diacyl-sn-glycerol 3-diphosphate + H2O 1,2-diacyl-sn-glycerol 3-phosphate + phosphate

The phosphatase activity of this enzyme is Mg2+-independent.

Related Research Articles

<span class="mw-page-title-main">Sphingolipid</span> Family of chemical compounds

Sphingolipids are a class of lipids containing a backbone of sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature. These compounds play important roles in signal transduction and cell recognition. Sphingolipidoses, or disorders of sphingolipid metabolism, have particular impact on neural tissue. A sphingolipid with a terminal hydroxyl group is a ceramide. Other common groups bonded to the terminal oxygen atom include phosphocholine, yielding a sphingomyelin, and various sugar monomers or dimers, yielding cerebrosides and globosides, respectively. Cerebrosides and globosides are collectively known as glycosphingolipids.

Phosphatidic acids are anionic phospholipids important to cell signaling and direct activation of lipid-gated ion channels. Hydrolysis of phosphatidic acid gives rise to one molecule each of glycerol and phosphoric acid and two molecules of fatty acids. They constitute about 0.25% of phospholipids in the bilayer.

<span class="mw-page-title-main">Glycerophospholipid</span> Class of lipids

Glycerophospholipids or phosphoglycerides are glycerol-based phospholipids. They are the main component of biological membranes in eukaryotic cells. They are a type of lipid, of which its composition affects membrane structure and properties. Two major classes are known: those for bacteria and eukaryotes and a separate family for archaea.

<span class="mw-page-title-main">Glycerol-3-phosphate dehydrogenase</span> Class of enzymes

Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate to sn-glycerol 3-phosphate.

The enzyme glycosylphosphatidylinositol diacylglycerol-lyase catalyzes the reaction

<span class="mw-page-title-main">Phosphatidylinositol diacylglycerol-lyase</span>

The enzyme phosphatidylinositol diacylglycerol-lyase catalyzes the following reaction:

In enzymology, an undecaprenyl-diphosphatase (EC 3.6.1.27) is an enzyme that catalyzes the chemical reaction

The enzyme glycerol-1-phosphatase (EC 3.1.3.21) catalyzes the reaction

<span class="mw-page-title-main">Phosphatidate phosphatase</span>

The enzyme phosphatidate phosphatase (PAP, EC 3.1.3.4) is a key regulatory enzyme in lipid metabolism, catalyzing the conversion of phosphatidate to diacylglycerol:

The enzyme polynucleotide 5′-phosphatase (RNA 5′-triphosphatase, RTPase, EC 3.1.3.33) is an enzyme that catalyzes the reaction

In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a digalactosyldiacylglycerol synthase is an enzyme that catalyzes the chemical reaction

In enzymology, a monogalactosyldiacylglycerol synthase is an enzyme that catalyzes the chemical reaction

In enzymology, a CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction

Phosphatidate cytidylyltransferase (CDS) is the enzyme that catalyzes the synthesis of CDP-diacylglycerol from cytidine triphosphate and phosphatidate.

<span class="mw-page-title-main">PPAP2A</span> Protein-coding gene in the species Homo sapiens

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.

<span class="mw-page-title-main">LPIN1</span> Protein-coding gene in the species Homo sapiens

Lipin-1 is a protein that in humans is encoded by the LPIN1 gene.

<span class="mw-page-title-main">AGK (gene)</span> Protein-coding gene in the species Homo sapiens

The human gene AGK encodes the enzyme mitochondrial acylglycerol kinase.

Diacylglycerol kinase (CTP dependent) (EC 2.7.1.174, DAG kinase, CTP-dependent diacylglycerol kinase, diglyceride kinase) is an enzyme with systematic name CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase. This enzyme catalyses the following chemical reaction

References

  1. Dillon DA, Wu WI, Riedel B, Wissing JB, Dowhan W, Carman GM (November 1996). "The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity". The Journal of Biological Chemistry. 271 (48): 30548–53. doi: 10.1074/jbc.271.48.30548 . PMID   8940025.
  2. Dillon DA, Chen X, Zeimetz GM, Wu WI, Waggoner DW, Dewald J, Brindley DN, Carman GM (April 1997). "Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity". The Journal of Biological Chemistry. 272 (16): 10361–6. doi:10.1074/jbc.272.16.10361. PMID   9099673.
  3. Wu WI, Liu Y, Riedel B, Wissing JB, Fischl AS, Carman GM (January 1996). "Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae". The Journal of Biological Chemistry. 271 (4): 1868–76. doi: 10.1074/jbc.271.4.1868 . PMID   8567632.
  4. Oshiro J, Han GS, Carman GM (November 2003). "Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1635 (1): 1–9. doi:10.1016/j.bbalip.2003.10.002. PMID   14642771.
  5. Carman GM (September 1997). "Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1348 (1–2): 45–55. doi:10.1016/s0005-2760(97)00095-7. PMID   9370315.
  6. Han GS, Johnston CN, Chen X, Athenstaedt K, Daum G, Carman GM (March 2001). "Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc". The Journal of Biological Chemistry. 276 (13): 10126–33. doi: 10.1074/jbc.m011421200 . PMID   11139591.