Disulfoglucosamine-6-sulfatase

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disulfoglucosamine-6-sulfatase
Identifiers
EC no. 3.1.6.11
CAS no. 37288-32-7
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MetaCyc metabolic pathway
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The enzyme disulfoglucosamine-6-sulfatase (EC 3.1.6.1) [1] catalyzes the reaction

2-N,6-O-disulfo-D-glucosamine + H2O 2-N-sulfo-D-glucosamine + sulfate

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name is 2-N,6-O-disulfo-D-glucosamine 6-sulfohydrolase. Other names in common use include N-sulfoglucosamine-6-sulfatase, and 6,N-disulfoglucosamine 6-O-sulfohydrolase.

Related Research Articles

Cerebroside-sulfatase (EC 3.1.6.8, arylsulfatase A, cerebroside sulfate sulfatase) is an enzyme with systematic name cerebroside-3-sulfate 3-sulfohydrolase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Steroid sulfatase</span> Protein-coding gene in the species Homo sapiens

Steroid sulfatase (STS), or steryl-sulfatase, formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded by the STS gene.

<span class="mw-page-title-main">Sulfatase</span> Class of enzymes

Sulfatases EC 3.1.6.- are enzymes of the esterase class that catalyze the hydrolysis of sulfate esters. These may be found on a range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. In the latter case the resultant N-sulfates can also be termed sulfamates.

<span class="mw-page-title-main">Arylsulfatase B</span> Mammalian protein found in Homo sapiens

Arylsulfatase B is an enzyme associated with mucopolysaccharidosis VI.

<span class="mw-page-title-main">Arylsulfatase</span>

Arylsulfatase (EC 3.1.6.1, sulfatase, nitrocatechol sulfatase, phenolsulfatase, phenylsulfatase, p-nitrophenyl sulfatase, arylsulfohydrolase, 4-methylumbelliferyl sulfatase, estrogen sulfatase) is a type of sulfatase enzyme with systematic name aryl-sulfate sulfohydrolase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Iduronate-2-sulfatase</span> Class of enzymes

Iduronate 2-sulfatase is a sulfatase enzyme associated with Hunter syndrome. It catalyses hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.

N-acetylgalactosamine-4-sulfatase is an enzyme with systematic name N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase. It catalyses the following reaction:

<span class="mw-page-title-main">N-acetylglucosamine-6-sulfatase</span> Protein-coding gene in the species Homo sapiens

N-acetylglucosamine-6-sulfatase (EC 3.1.6.14, glucosamine (N-acetyl)-6-sulfatase, systematic name N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase) is an enzyme that in humans is encoded by the GNS gene. It is deficient in Sanfilippo Syndrome type IIId. It catalyses the hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate

<span class="mw-page-title-main">N-sulfoglucosamine sulfohydrolase</span>

In enzymology, a N-sulfoglucosamine sulfohydrolase (EC 3.10.1.1), otherwise known as SGSH, is an enzyme that catalyzes the chemical reaction

In enzymology, a phosphoadenylylsulfatase (EC 3.6.2.2) is an enzyme that catalyzes the chemical reaction

The enzyme choline-sulfatase (EC 3.1.6.6) catalyzes the reaction

The enzyme chondro-4-sulfatase (EC 3.1.6.9) catalyzes the reaction

The enzyme chondro-6-sulfatase (EC 3.1.6.10) catalyzes the reaction

The enzyme D-lactate-2-sulfatase (EC 3.1.6.17) catalyzes the reaction

The enzyme monomethyl-sulfatase (EC 3.1.6.16) catalyzes the reaction

In enzymology, a glucuronate-2-sulfatase is an enzyme that catalyzes the chemical reaction of cleaving off the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.

The enzyme N-acetylgalactosamine-6-sulfatase catalyzes the chemical reaction of cleaving off the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of the macromolecule chondroitin sulfate and, similarly, of the D-galactose 6-sulfate units of the macromolecule keratan sulfate.

The enzyme N-sulfoglucosamine-3-sulfatase catalyzes cleaving off the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.

The enzyme glucuronosyl-disulfoglucosamine glucuronidase (EC 3.2.1.56) catalyzes the following chemical reaction:

<span class="mw-page-title-main">SGSH</span> Protein-coding gene in the species Homo sapiens

N-sulphoglucosamine sulphohydrolase is an enzyme that in humans is encoded by the SGSH gene.

References

  1. Dietrich CP (January 1969). "Enzymic degradation of heparin. A sulphamidase and a sulphoesterase from Flavobacterium heparinum". The Biochemical Journal. 111 (1): 91–5. PMC   1187498 . PMID   5775690.