Dolichylphosphate-glucose phosphodiesterase

Last updated
dolichylphosphate-glucose phosphodiesterase
Identifiers
EC no. 3.1.4.48
CAS no. 89287-42-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

The enzyme dolichylphosphate-glucose phosphodiesterase (EC 3.1.4.48) [1] catalyzes the reaction

dolichyl β-D-glucosyl phosphate + H2O dolichyl phosphate + D-glucose

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is dolichyl-β-D-glucosyl-phosphate dolichylphosphohydrolase. Other names in common use include dolichol phosphoglucose phosphodiesterase, and Dol-P-Glc phosphodiesterase. This enzyme participates in n-glycan biosynthesis.

Related Research Articles

<span class="mw-page-title-main">Glycogen phosphorylase</span> Class of enzymes

Glycogen phosphorylase is one of the phosphorylase enzymes. Glycogen phosphorylase catalyzes the rate-limiting step in glycogenolysis in animals by releasing glucose-1-phosphate from the terminal alpha-1,4-glycosidic bond. Glycogen phosphorylase is also studied as a model protein regulated by both reversible phosphorylation and allosteric effects.

<span class="mw-page-title-main">Cyclic nucleotide phosphodiesterase</span>

3′,5′-cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a nucleoside 3′,5′-cyclic phosphate to a nucleoside 5′-phosphate:

<span class="mw-page-title-main">Sucrose phosphorylase</span>

Sucrose phosphorylase is an important enzyme in the metabolism of sucrose and regulation of other metabolic intermediates. Sucrose phosphorylase is in the class of hexosyltransferases. More specifically it has been placed in the retaining glycoside hydrolases family although it catalyzes a transglycosidation rather than hydrolysis. Sucrose phosphorylase catalyzes the conversion of sucrose to D-fructose and α-D-glucose-1-phosphate. It has been shown in multiple experiments that the enzyme catalyzes this conversion by a double displacement mechanism.

The enzyme dolichylphosphate-mannose phosphodiesterase (EC 3.1.4.49) catalyzes the reaction

The enzyme glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase (EC 3.1.4.51) catalyzes the reaction

The enzyme 6-phospho-β-glucosidase (EC 3.2.1.86) catalyzes the following reaction:

In enzymology, a 1,3-beta-D-glucan phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, a 1,3-beta-oligoglucan phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, a cellodextrin phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, a dolichyl-phosphate beta-glucosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a dolichyl-phosphate-mannose-protein mannosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glucosylglycerol-phosphate synthase is an enzyme that catalyzes the chemical reaction

In enzymology, a kojibiose phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, a laminaribiose phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, a poly(glycerol-phosphate) alpha-glucosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a poly(ribitol-phosphate) beta-glucosyltransferase is an enzyme that catalyzes the chemical reaction

Dolichyl <i>beta</i>-<small>D</small>-glucosyl phosphate Chemical compound

Dolichyl β-d-glucosyl phosphate is a molecule involved in glycosylation. It is a polyprenyl glycosyl phosphate having dolichol as the polyprenyl component and β-d-glucose as the glycosyl component.

<span class="mw-page-title-main">ALG10 (enzyme class)</span>

Dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase is an enzyme with systematic name dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha- -D-Man-alpha- - -D-Man-alpha- )-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 2-alpha-D-glucosyltransferase.

<span class="mw-page-title-main">ALG8 (enzyme class)</span>

Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase is an enzyme with systematic name dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha- -D-Man-alpha- - -D-Man-alpha- )-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase.

<span class="mw-page-title-main">ALG6 (enzyme class)</span>

Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase is an enzyme with systematic name dolichyl beta-D-glucosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha- -D-Man-alpha- - -D-Man-alpha- )-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase.

References

  1. Crean EV (1984). "Synthesis and degradation of dolichyl phosphoryl glucose by the cellular slime mold, Dictyostelium discoideum". Biochim. Biophys. Acta. 792: 149–157. doi:10.1016/0005-2760(84)90216-9.