Exodeoxyribonuclease I

Exodeoxyribonuclease I
Identifiers
EC no.	3.1.11.1
CAS no.	9037-46-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Exodeoxyribonuclease I (EC 3.1.11.1, Escherichia coli exonuclease I, E. coli exonuclease I, exonuclease I) is an enzyme ^{[1] [2] [3]} that catalyses the following chemical reaction:

Exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates

Preference for^{[ clarification needed ]} single-stranded DNA. The Escherichia coli enzyme hydrolyses glucosylated DNA.

References

1. Blakesley RW, Dodgson JB, Nes IF, Wells RD (October 1977). "Duplex regions in "single-stranded" phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius". The Journal of Biological Chemistry. 252 (20): 7300–6. doi: 10.1016/S0021-9258(19)66969-3 . PMID   71298.
2. Kelley RB, Atkinson MR, Huberman JA, Kornberg A (1969). "Excision of thymine dimers and other mismatched sequences by DNA polymerases of Escherichia coli". Nature. 224 (5218): 495–501. Bibcode:1969Natur.224..495K. doi:10.1038/224495a0.
3. Lehman IR, Nussbaum AL (August 1964). "The deoxyribonucleases of Escherichia coli. V. On the specificity of exonuclease I (phosphodiesterase)". The Journal of Biological Chemistry. 239 (8): 2628–36. doi: 10.1016/S0021-9258(18)93898-6 . PMID   14235546.

External links

• Exodeoxyribonuclease+I at the U.S. National Library of Medicine Medical Subject Headings (MeSH)