Fibroblast growth factor receptor-like 1

FGFRL1
Identifiers
Aliases	FGFRL1 , FGFR5, FHFR, fibroblast growth factor receptor-like 1, fibroblast growth factor receptor like 1, FGFR-5
External IDs	OMIM: 605830 MGI: 2150920 HomoloGene: 11067 GeneCards: FGFRL1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	1,026,898 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	108,854,790 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; body of pancreas; ; ascending aorta; ; left adrenal gland; ; right adrenal gland; ; right lobe of liver; ; stromal cell of endometrium; ; left uterine tube;
	Top expressed in
	basilar part of occipital bone; ; larynx; ; Paneth cell; ; ascending aorta; ; thumb; ; aortic valve; ; index finger; ; white adipose tissue; ; brown adipose tissue; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor binding ; heparin binding ; fibroblast growth factor-activated receptor activity ;
Cellular component	integral component of membrane ; Golgi apparatus ; transport vesicle ; cell-cell contact zone ; membrane ; plasma membrane ;
Biological process	skeletal system development ; ventricular septum morphogenesis ; cell-cell adhesion via plasma-membrane adhesion molecules ; substrate adhesion-dependent cell spreading ; protein homooligomerization ; heart valve morphogenesis ; protein heterooligomerization ; diaphragm development ; negative regulation of cell population proliferation ; fibroblast growth factor receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	53834
	116701
	ENSG00000127418
	ENSMUSG00000008090
	Q8N441
	Q91V87
	NM_001004356 ; NM_001004358 ; NM_021923 ; NM_001370296 ; NM_017862
	NM_001164259 ; NM_054071
	NP_001004356 ; NP_001004358 ; NP_068742 ; NP_001357225 ; NP_001004356.1
	NP_001157731 ; NP_473412
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 10, 2023

Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene.^[5]

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.^[5]

Transgenic mice expressing the giraffe ortholog of FGFRL1 are resistant against hypertension induced by angiotensin II.^[6]

Related Research Articles

Fibroblast growth factor 2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules. Fibroblast growth factor protein was first purified in 1975; soon thereafter three variants were isolated: 'basic FGF' (FGF2); Heparin-binding growth factor-2; and Endothelial cell growth factor-2. Gene sequencing revealed that this group is the same FGF2 protein and is a member of a family of FGF proteins.

Fibroblast growth factor 1, (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.

Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor.

Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome, and clonal eosinophilias.

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334.

Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.

Fibroblast growth factor 18 (FGF18) is a protein that is encoded by the Fgf18 gene in humans. The protein was first discovered in 1998, when two newly-identified murine genes Fgf17 and Fgf18 were described and confirmed as being closely related by sequence homology to Fgf8. The three proteins were eventually grouped into the FGF8 subfamily, which contains several of the endocrine FGF superfamily members FGF8, FGF17, and FGF18. Subsequent studies identified FGF18's role in promoting chondrogenesis, and an apparent specific activity for the generation of the hyaline cartilage in articular joints.

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.

Ubiquitin-associated and SH3 domain-containing protein B is a protein that in humans is encoded by the UBASH3B gene.

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene.

Tyrosine-protein kinase STYK1 is an enzyme that in humans is encoded by the STYK1 gene.

Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.

Epidermal growth factor receptor kinase substrate 8-like protein 3 is an enzyme that in humans is encoded by the EPS8L3 gene.

Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000127418 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008090 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: FGFRL1 fibroblast growth factor receptor-like 1".
↑ Liu, Chang; Gao, Jianbo; Cui, Xinxin; Li, Zhipeng; Chen, Lei; Yuan, Yuan; Zhang, Yaolei; Mei, Liangwei; Zhao, Lan; Cai, Dan; Hu, Mingliang; Zhou, Botong; Li, Zihe; Qin, Tao; Si, Huazhe (2021-03-19). "A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe". Science Advances. 7 (12). doi:10.1126/sciadv.abe9459. ISSN 2375-2548. PMC 7968835 . PMID 33731352.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wiedemann M, Trueb B (2001). "Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors". Genomics. 69 (2): 275–279. doi:10.1006/geno.2000.6332. PMID 11031111.
Kim I, Moon S, Yu K, et al. (2001). "A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas(1)". Biochim. Biophys. Acta. 1518 (1–2): 152–6. doi:10.1016/s0167-4781(00)00282-7. PMID 11267671.
Sleeman M, Fraser J, McDonald M, et al. (2001). "Identification of a new fibroblast growth factor receptor, FGFR5". Gene. 271 (2): 171–182. doi:10.1016/S0378-1119(01)00518-2. PMID 11418238.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Trueb B, Zhuang L, Taeschler S, Wiedemann M (2003). "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues". J. Biol. Chem. 278 (36): 33857–33865. doi: 10.1074/jbc.M300281200 . PMID 12813049.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Antoine M, Wirz W, Tag CG, et al. (2005). "Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells". Growth Factors. 23 (2): 87–95. doi:10.1080/08977190500096004. PMID 16019430. S2CID 27380246.
Schild C, Trueb B (2006). "Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors". Int. J. Mol. Med. 16 (6): 1169–73. doi:10.3892/ijmm.16.6.1169. PMID 16273302.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000127418 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008090 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: FGFRL1 fibroblast growth factor receptor-like 1".

[6] Liu, Chang; Gao, Jianbo; Cui, Xinxin; Li, Zhipeng; Chen, Lei; Yuan, Yuan; Zhang, Yaolei; Mei, Liangwei; Zhao, Lan; Cai, Dan; Hu, Mingliang; Zhou, Botong; Li, Zihe; Qin, Tao; Si, Huazhe (2021-03-19). "A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe". Science Advances. 7 (12). doi:10.1126/sciadv.abe9459. ISSN 2375-2548. PMC 7968835 . PMID 33731352.

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Fibroblast growth factor receptor-like 1

Related Research Articles

References

Further reading