Glycerol-1-phosphatase

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glycerol-1-phosphatase
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EC no. 3.1.3.21
CAS no. 37228-75-4
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The enzyme glycerol-1-phosphatase (EC 3.1.3.21) catalyzes the reaction

glycerol 1-phosphate + H2O glycerol + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is glycerol-1-phosphate phosphohydrolase. Other names in common use include α-glycerophosphatase, α-glycerol phosphatase, glycerol 3-phosphatase, glycerol-3-phosphate phosphatase, and glycerol 3-phosphate phosphohydrolase. This enzyme participates in glycerolipid metabolism.

Among the organisms that have been shown to express this enzymatic activity are A. thaliana (plant) via the AtSgpp and AtGpp gene products; [1] D. salina (alga); [2] S. cerevisiae (fungus) via the GPP1/RHR2/YIL053W and GPP2/HOR2/YER062C gene products; [3] [4] C. albicans (fungus) via the GPP1 gene product; [5] M. tuberculosis (bacteria) via the rv1692 gene product; [6] and C57BL/6N mice and Wistar rats (mammals) via the PGP gene product. [7]

Related Research Articles

<span class="mw-page-title-main">Glucose 6-phosphatase</span> Enzyme

The enzyme glucose 6-phosphatase (EC 3.1.3.9, G6Pase; systematic name D-glucose-6-phosphate phosphohydrolase) catalyzes the hydrolysis of glucose 6-phosphate, resulting in the creation of a phosphate group and free glucose:

<span class="mw-page-title-main">Glycerol-3-phosphate dehydrogenase</span> Class of enzymes

Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate to sn-glycerol 3-phosphate.

In enzymology, an undecaprenyl-diphosphatase (EC 3.6.1.27) is an enzyme that catalyzes the chemical reaction

In enzymology, a xenobiotic-transporting ATPase (EC 3.6.3.44) is an enzyme that catalyzes the chemical reaction

The enzyme 2-carboxy-D-arabinitol-1-phosphatase (CA1Pase; EC 3.1.3.63) catalyzes the reaction

The enzyme 2-deoxyglucose-6-phosphatase (EC 3.1.3.68) catalyzes the reaction

The enzyme glucosylglycerol 3-phosphatase (EC 3.1.3.69) catalyzes the reaction

The enzyme glycerophosphoinositol inositolphosphodiesterase (EC 3.1.4.43) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Phosphatidate phosphatase</span>

The enzyme phosphatidate phosphatase (PAP, EC 3.1.3.4) is a key regulatory enzyme in lipid metabolism, catalyzing the conversion of phosphatidate to diacylglycerol:

The enzyme phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) catalyzes the chemical reaction

The enzyme phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) that catalyzes the reaction

<span class="mw-page-title-main">Phosphoglycolate phosphatase</span>

Phosphoglycolate phosphatase(EC 3.1.3.18; systematic name 2-phosphoglycolate phosphohydrolase), also commonly referred to as phosphoglycolate hydrolase, 2-phosphoglycolate phosphatase, P-glycolate phosphatase, and phosphoglycollate phosphatase, is an enzyme responsible for catalyzing the conversion of 2-phosphoglycolate into glycolate and phosphate:

The enzyme pyridoxal phosphatase (EC 3.1.3.74) catalyzes the reaction

<span class="mw-page-title-main">PPAP2A</span> Protein-coding gene in the species Homo sapiens

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.

<span class="mw-page-title-main">NAGPA</span> Protein-coding gene in the species Homo sapiens

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase is an enzyme that in humans is encoded by the NAGPA gene.

<span class="mw-page-title-main">NUDT3</span> Protein-coding gene in the species Homo sapiens

Diphosphoinositol polyphosphate phosphohydrolase 1 is an enzyme that in humans is encoded by the NUDT3 gene.

<span class="mw-page-title-main">SGPP1</span> Protein-coding gene in the species Homo sapiens

Sphingosine-1-phosphate phosphatase 1 is an enzyme that in humans is encoded by the SGPP1 gene.

<span class="mw-page-title-main">Glycerol-3-phosphate dehydrogenase (quinone)</span>

Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3 is an enzyme with systematic name sn-glycerol 3-phosphate:quinone oxidoreductase. This enzyme catalyses the following chemical reaction

Diacylglycerol diphosphate phosphatase (EC 3.1.3.81, DGPP phosphatase, DGPP phosphohydrolase, DPP1, DPPL1, DPPL2, PAP2, pyrophosphate phosphatase) is an enzyme with systematic name 1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase. This enzyme catalyses the following chemical reaction

Steroid-transporting ATPase (EC 3.6.3.45, pleiotropic-drug-resistance protein, PDR protein) is an enzyme with systematic name ATP phosphohydrolase (steroid-exporting). This enzyme catalyses the following chemical reaction

References

  1. ↑ Caparrós-Martín JA, McCarthy-Suárez I, Culiáñez-Macià FA (September 2014). "The kinetic analysis of the substrate specificity of motif 5 in a HAD hydrolase-type phosphosugar phosphatase of Arabidopsis thaliana". Planta (Abstract). 240 (3): 479–87. doi:10.1007/s00425-014-2102-6. PMID   24915748. S2CID   8764480 – via SpringerLink.
  2. ↑ Sussman I, Avron M (13 October 1981). "Characterization and partial purification of DL-glycerol-1-phosphatase from Dunaliella salina". Biochimica et Biophysica Acta (Abstract). 661 (2): 199–204. doi:10.1016/0005-2744(81)90004-8. PMID   6252970.
  3. ↑ Norbeck J, Påhlman AK, Akhtar N, et al. (7 June 1996). "Purification and Characterization of Two Isoenzymes of DL-Glycerol-3-phosphatase from Saccharomyces cerevisiae". Journal of Biological Chemistry . 271 (23): 13875–81. doi: 10.1074/jbc.271.23.13875 . PMID   8662716.
  4. ↑ Påhlman AK, Granath K, Ansell R, et al. (2 February 2001). "The Yeast Glycerol 3-Phosphatases Gpp1p and Gpp2p Are Required for Glycerol Biosynthesis and Differentially Involved in the Cellular Responses to Osmotic, Anaerobic, and Oxidative Stress". Journal of Biological Chemistry . 276 (5): 3555–63. doi: 10.1074/jbc.M007164200 . PMID   11058591.
  5. ↑ Fan J, Whiteway M, Shen SH (April 2005). "Disruption of a gene encoding glycerol 3-phosphatase from Candida albicans impairs intracellular glycerol accumulation-mediated salt-tolerance". FEMS Microbiology Letters . 245 (1): 107–16. doi: 10.1016/j.femsle.2005.02.031 . PMID   15796987 – via Oxford University Press.
  6. ↑ Larrouy-Maumus G, Biswas T, Hunt DM, et al. (25 June 2013). "Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis". Proceedings of the National Academy of Sciences of the United States of America . 110 (28): 11320–5. Bibcode:2013PNAS..11011320L. doi: 10.1073/pnas.1221597110 . PMC   3710836 . PMID   23801751.
  7. ↑ Mugago Y, Zhao S, Seifried A, et al. (11 January 2016). "Identification of a mammalian glycerol-3-phosphate phosphatase". Proceedings of the National Academy of Sciences of the United States of America . 113 (4): E430–9. doi: 10.1073/pnas.1514375113 . PMC   4743820 . PMID   26755581.


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