Glycosulfatase

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glycosulfatase
Identifiers
EC no. 3.1.6.3
CAS no. 9025-61-0
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The enzyme glycosulfatase (EC 3.1.6.3) [1] [2] [3] catalyzes the reaction

D-glucose 6-sulfate + H2O D-glucose + sulfate

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is sugar-sulfate sulfohydrolase. This enzyme is also called glucosulfatase. This enzyme participates in glycolysis and gluconeogenesis.

Related Research Articles

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<span class="mw-page-title-main">Gallic acid</span> 3,4,5-Trihydroxybenzoic acid

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<span class="mw-page-title-main">Trehalase</span> Class of enzymes

The enzyme Trehalase is a glycoside hydrolase, produced by cells in the brush border of the small intestine, which catalyzes the conversion of trehalose to glucose. It is found in most animals.

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<span class="mw-page-title-main">Glucuronic acid</span> Sugar acid

Glucuronic acid is a uronic acid that was first isolated from urine. It is found in many gums such as gum arabic, xanthan, and kombucha tea and is important for the metabolism of microorganisms, plants and animals.

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Glycogen synthase is a key enzyme in glycogenesis, the conversion of glucose into glycogen. It is a glycosyltransferase that catalyses the reaction of UDP-glucose and n to yield UDP and n+1.

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Sulfatases EC 3.1.6.- are enzymes of the esterase class that catalyze the hydrolysis of sulfate esters. These may be found on a range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. In the latter case the resultant N-sulfates can also be termed sulfamates.

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<span class="mw-page-title-main">N-acetylglucosamine-6-sulfatase</span> Protein-coding gene in the species Homo sapiens

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In enzymology, an inositol-3-phosphate synthase is an enzyme that catalyzes the chemical reaction

An aryl sulfotransferase is an enzyme that transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate.

In enzymology, a tyrosine-ester sulfotransferase is an enzyme that catalyzes the chemical reaction

The enzyme 6-acetylglucose deacetylase (EC 3.1.1.33) catalyzes the reaction

The enzyme N-acetylgalactosamine-6-sulfatase catalyzes the chemical reaction of cleaving off the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of the macromolecule chondroitin sulfate and, similarly, of the D-galactose 6-sulfate units of the macromolecule keratan sulfate.

The enzyme N-sulfoglucosamine-3-sulfatase catalyzes cleaving off the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.

In enzymology, a N-hydroxythioamide S-beta-glucosyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Thymidine diphosphate glucose</span> Chemical compound

Thymidine diphosphate glucose is a nucleotide-linked sugar consisting of deoxythymidine diphosphate linked to glucose. It is the starting compound for the syntheses of many deoxysugars.

<span class="mw-page-title-main">Estradiol glucuronide</span> Chemical compound

Estradiol glucuronide, or estradiol 17β-D-glucuronide, is a conjugated metabolite of estradiol. It is formed from estradiol in the liver by UDP-glucuronyltransferase via attachment of glucuronic acid and is eventually excreted in the urine by the kidneys. It has much higher water solubility than does estradiol. Glucuronides are the most abundant estrogen conjugates.

References

    • Dodgson KS (1961). "Glycosulphatase: observations on the activity of partially purified preparations towards the sulphate esters of certain monosaccharides and steroids". Biochem. J. 78 (2): 324–333. doi:10.1042/bj0780324. PMC   1205270 . PMID   16748876.
  1. Egami F; Takahaski N (1955). "Syntheses of adenosinesulfuric acids". Bull. Chem. Soc. Jpn. 28 (9): 666–668. doi: 10.1246/bcsj.28.666 .
  2. Roy, AB (1960). "The synthesis and hydrolysis of sulfate esters". Adv. Enzymol. Relat. Subj. Biochem. 22: 205–235.