L-threonine 3-dehydrogenase

Last updated
L-threonine 3-dehydrogenase
2ejv.jpg
L-threonine 3-dehydrogenase homotetramer, Thermus thermophilus
Identifiers
EC no. 1.1.1.103
CAS no. 9067-99-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins
L-Threonine dehydrogenase
Identifiers
SymbolTDH
NCBI gene 157739
HGNC 15547
RefSeq NM_152566
UniProt Q8IZJ6
Other data
EC number 1.1.1.103
Locus Chr. 8 p23.1
Search for
Structures Swiss-model
Domains InterPro

In enzymology, a L-threonine 3-dehydrogenase (EC 1.1.1.103) is an enzyme that catalyzes the chemical reaction

L-threonine + NAD+ L-2-amino-3-oxobutanoate + NADH + H+

Thus, the two substrates of this enzyme are L-threonine and NAD+, whereas its 3 products are L-2-amino-3-oxobutanoate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-threonine:NAD+ oxidoreductase. Other names in common use include L-threonine dehydrogenase, threonine 3-dehydrogenase, and threonine dehydrogenase. This enzyme participates in glycine, serine and threonine metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2D8A, 2DFV, and 2DQ4.

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References


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