Pyrethroid hydrolase

Pyrethroid hydrolase
Identifiers
EC no.	3.1.1.88
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme pyrethroid hydrolase (EC 3.1.1.88, pyrethroid-hydrolyzing carboxylesterase, pyrethroid-hydrolysing esterase, pyrethroid-hydrolyzing esterase, pyrethroid-selective esterase, pyrethroid-cleaving enzyme, permethrinase, PytH, EstP; systematic name pyrethroid-ester hydrolase) ^{[1] [2] [3] [4] [5] [6]} catalyses the reaction

trans-permethrin + H₂O ${\displaystyle \rightleftharpoons }$ (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

The enzyme is involved in degradation of pyrethroid pesticides.

References

1. Wang BZ, Guo P, Hang BJ, Li L, He J, Li SP (September 2009). "Cloning of a novel pyrethroid-hydrolyzing carboxylesterase gene from Sphingobium sp. strain JZ-1 and characterization of the gene product". Applied and Environmental Microbiology. 75 (17): 5496–500. Bibcode:2009ApEnM..75.5496W. doi:10.1128/aem.01298-09. PMC   2737939 . PMID   19581484.
2. Wu PC, Liu YH, Wang ZY, Zhang XY, Li H, Liang WQ, Luo N, Hu JM, Lu JQ, Luan TG, Cao LX (February 2006). "Molecular cloning, purification, and biochemical characterization of a novel pyrethroid-hydrolyzing esterase from Klebsiella sp. strain ZD112". Journal of Agricultural and Food Chemistry. 54 (3): 836–42. Bibcode:2006JAFC...54..836W. doi:10.1021/jf052691u. PMID   16448191.
3. Liang WQ, Wang ZY, Li H, Wu PC, Hu JM, Luo N, Cao LX, Liu YH (September 2005). "Purification and characterization of a novel pyrethroid hydrolase from Aspergillus niger ZD11". Journal of Agricultural and Food Chemistry. 53 (19): 7415–20. Bibcode:2005JAFC...53.7415L. doi:10.1021/jf051460k. PMID   16159167.
4. Stok JE, Huang H, Jones PD, Wheelock CE, Morisseau C, Hammock BD (July 2004). "Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes". The Journal of Biological Chemistry. 279 (28): 29863–9. doi: 10.1074/jbc.m403673200 . PMID   15123619.
5. Maloney SE, Maule A, Smith AR (July 1993). "Purification and preliminary characterization of permethrinase from a pyrethroid-transforming strain of Bacillus cereus". Applied and Environmental Microbiology. 59 (7): 2007–13. Bibcode:1993ApEnM..59.2007M. doi:10.1128/aem.59.7.2007-2013.1993. PMC   182228 . PMID   8357241.
6. Guo, P.; Wang, B.; Hang, B.; Li, L.; Ali, W.; He, J.; Li, S. (2009). "Pyrethroid-degrading Sphingobium sp. JZ-2 and the purification and characterization of a novel pyrethroid hydrolase". Int. Biodeter. Biodegrad. 63 (8): 1107–1112. Bibcode:2009IBiBi..63.1107G. doi:10.1016/j.ibiod.2009.09.008.

External links

• Pyrethroid+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)