Ro07-3953

Last updated

Ro07-3953
Ro07-3953 structure.png
Legal status
Legal status
Identifiers
  • 7-chloro-5-(2,6-difluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C15H91ClF2N2O
Molar mass 389.35 g·mol−1
3D model (JSmol)
  • C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=C(C=CC=C3F)F
  • InChI=1S/C15H9ClF2N2O/c16-8-4-5-12-9(6-8)15(19-7-13(21)20-12)14-10(17)2-1-3-11(14)18/h1-6H,7H2,(H,20,21)
  • Key:WENMWXYJTWETRE-UHFFFAOYSA-N

Ro07-3953 (Diflunordazepam) is a benzodiazepine derivative which is the 2',6'-difluoro derivative of nordazepam. It was invented in the 1970s but was never marketed, [1] [2] however it has recently appeared on the market as a designer drug, first reported in Sweden in December 2024. [3] [4]

See also

References

  1. ↑ Maddalena DJ, Johnston GA (February 1995). "Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural networks". Journal of Medicinal Chemistry. 38 (4): 715–724. doi:10.1021/jm00004a017. PMID   7861419.
  2. ↑ So SS, Karplus M (December 1996). "Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors". Journal of Medicinal Chemistry. 39 (26): 5246–5256. doi:10.1021/jm960536o. PMID   8978853.
  3. ↑ "EU Early Warning System – Formal Notification: EU‑EWS‑RCS‑FN‑2024‑0044 (Ro 07‑3953)" (PDF). EU Early Warning System (EWS) / EUDA. 16 December 2024.
  4. ↑ "European Drug Report 2025 – Full Book" (PDF). European Union Drugs Agency (euda.europa.eu). 6 June 2025.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.