Type I site-specific deoxyribonuclease

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Type I site-specific deoxyribonuclease
Identifiers
EC no. 3.1.21.3
CAS no. 37263-09-5
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NCBI proteins

Type I site-specific deoxyribonuclease (EC 3.1.21.3, type I restriction enzyme, deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent), restriction-modification system, deoxyribonuclease (adenosine triphosphate-hydrolyzing), adenosine triphosphate-dependent deoxyribonuclease, ATP-dependent DNase, type 1 site-specific deoxyribonuclease) is an enzyme. [1] This enzyme catalyses the following chemical reaction

Contents

Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolysed

They have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine.

See also

References

  1. ↑ Roberts RJ (April 1990). "Restriction enzymes and their isoschizomers". Nucleic Acids Research. 18 Suppl (Suppl): 2331–65. doi:10.1093/nar/18.suppl.2331. PMC   331877 . PMID   2159140.
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