ANGPT4

ANGPT4
Identifiers
Aliases	ANGPT4 , AGP4, ANG-3, ANG4, ANG3, angiopoietin 4
External IDs	OMIM: 603705; MGI: 1336887; HomoloGene: 36302; GeneCards: ANGPT4; OMA:ANGPT4 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	916,334 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	151,787,257 bp
RNA expression pattern
	Top expressed in
	subcutaneous adipose tissue; ; left uterine tube; ; right ovary; ; canal of the cervix; ; popliteal artery; ; tibial arteries; ; body of uterus; ; left ovary; ; ectocervix; ; right coronary artery;
	Top expressed in
	decidua; ; stroma of bone marrow; ; gastrula; ; body of femur; ; lip; ; molar; ; efferent ductule; ; vas deferens; ; skin of external ear; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	receptor tyrosine kinase binding ; transmembrane receptor protein tyrosine kinase activator activity ;
Cellular component	extracellular region ; extracellular space ;
Biological process	Notch signaling pathway ; positive regulation of endothelial cell migration ; negative regulation of angiogenesis ; negative regulation of apoptotic process ; negative regulation of blood vessel endothelial cell migration ; cellular response to hypoxia ; endothelial cell proliferation ; angiogenesis ; positive regulation of blood vessel endothelial cell migration ; leukocyte migration ; positive regulation of angiogenesis ; positive regulation of peptidyl-tyrosine phosphorylation ; activation of transmembrane receptor protein tyrosine kinase activity ;
	Sources:Amigo / QuickGO
Orthologs
	51378
	11602
	ENSG00000101280
	ENSMUSG00000027460
	Q9Y264
	Q9WVH6
	NM_015985 ; NM_001322809
	NM_009641
	NP_001309738 ; NP_057069
	NP_033771
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 06, 2024

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.^[5]^[6]^[7]

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells.

The protein encoded by this gene functions as an agonist and is an angiopoietin.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101280 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027460 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD (Apr 1999). "Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans". Proc Natl Acad Sci U S A. 96 (5): 1904–9. Bibcode:1999PNAS...96.1904V. doi: 10.1073/pnas.96.5.1904 . PMC 26709 . PMID 10051567.
↑ Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S (May 1999). "Angiopoietin-3, a novel member of the angiopoietin family". FEBS Lett. 448 (2–3): 254–6. doi:10.1016/S0014-5793(99)00381-6. PMID 10218486. S2CID 11265148.
1 2 "Entrez Gene: ANGPT4 angiopoietin 4".

External links

Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser .

Grosios K, Leek JP, Markham AF, et al. (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet. 84 (1–2): 118–20. doi:10.1159/000015235. PMID 10343124. S2CID 40232421.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Ward EG, Grosios K, Markham AF, Jones PF (2002). "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3–4): 147–54. doi:10.1159/000048807. PMID 11856872. S2CID 22445942.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi: 10.1007/s100380300025 . PMID 12624729.
Yamakawa M, Liu LX, Belanger AJ, et al. (2004). "Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis". Am. J. Physiol. Renal Physiol. 287 (4): F649–57. doi:10.1152/ajprenal.00028.2004. PMID 15198927.
Lee HJ, Cho CH, Hwang SJ, et al. (2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200–8. doi: 10.1096/fj.03-1466com . PMID 15284220. S2CID 19001234.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Oliner J, Min H, Leal J, et al. (2004). "Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2". Cancer Cell. 6 (5): 507–16. doi: 10.1016/j.ccr.2004.09.030 . PMID 15542434.
Olsen MW, Ley CD, Junker N, et al. (2006). "Angiopoietin-4 Inhibits Angiogenesis and Reduces Interstitial Fluid Pressure". Neoplasia. 8 (5): 364–72. doi:10.1593/neo.06127. PMC 1592453 . PMID 16790085.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101280 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027460 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10051567-5] Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD (Apr 1999). "Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans". Proc Natl Acad Sci U S A. 96 (5): 1904–9. Bibcode:1999PNAS...96.1904V. doi: 10.1073/pnas.96.5.1904 . PMC 26709 . PMID 10051567.

[pmid10218486-6] Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S (May 1999). "Angiopoietin-3, a novel member of the angiopoietin family". FEBS Lett. 448 (2–3): 254–6. doi:10.1016/S0014-5793(99)00381-6. PMID 10218486. S2CID 11265148.

[entrez-7] 1 2 "Entrez Gene: ANGPT4 angiopoietin 4".

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ANGPT4

Contents

Related Research Articles

References

External links

Further reading