ANGPT4

ANGPT4
Identifiers
Aliases	ANGPT4 , AGP4, ANG-3, ANG4, ANG3, angiopoietin 4
External IDs	OMIM: 603705; MGI: 1336887; HomoloGene: 36302; GeneCards: ANGPT4; OMA:ANGPT4 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 869,900 bp [1] End 916,334 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 G3|2 74.83 cM Start 151,753,130 bp [2] End 151,787,257 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in subcutaneous adipose tissue left uterine tube right ovary canal of the cervix popliteal artery tibial arteries body of uterus left ovary ectocervix right coronary artery Top expressed in decidua stroma of bone marrow gastrula body of femur lip molar efferent ductule vas deferens skin of external ear abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding transmembrane receptor protein tyrosine kinase activator activity Cellular component extracellular region extracellular space Biological process Notch signaling pathway positive regulation of endothelial cell migration negative regulation of angiogenesis negative regulation of apoptotic process negative regulation of blood vessel endothelial cell migration cellular response to hypoxia endothelial cell proliferation angiogenesis positive regulation of blood vessel endothelial cell migration leukocyte migration positive regulation of angiogenesis positive regulation of peptidyl-tyrosine phosphorylation activation of transmembrane receptor protein tyrosine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51378 11602 Ensembl ENSG00000101280 ENSMUSG00000027460 UniProt Q9Y264 Q9WVH6 RefSeq (mRNA) NM_015985 NM_001322809 NM_009641 RefSeq (protein) NP_001309738 NP_057069 NP_033771 Location (UCSC) Chr 20: 0.87 – 0.92 Mb Chr 2: 151.75 – 151.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene. ^{[5] [6] [7]}

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells.

The protein encoded by this gene functions as an agonist and is an angiopoietin. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000101280 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027460 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD (Apr 1999). "Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans". Proc Natl Acad Sci U S A. 96 (5): 1904–9. Bibcode:1999PNAS...96.1904V. doi: 10.1073/pnas.96.5.1904 . PMC   26709 . PMID   10051567.
6. Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S (May 1999). "Angiopoietin-3, a novel member of the angiopoietin family". FEBS Lett. 448 (2–3): 254–6. doi:10.1016/S0014-5793(99)00381-6. PMID   10218486. S2CID   11265148.
7. "Entrez Gene: ANGPT4 angiopoietin 4".

External links

• Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser .

Further reading

• Grosios K, Leek JP, Markham AF, et al. (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet. 84 (1–2): 118–20. doi:10.1159/000015235. PMID   10343124. S2CID   40232421.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Ward EG, Grosios K, Markham AF, Jones PF (2002). "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3–4): 147–54. doi:10.1159/000048807. PMID   11856872. S2CID   22445942.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi: 10.1007/s100380300025 . PMID   12624729.
• Yamakawa M, Liu LX, Belanger AJ, et al. (2004). "Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis". Am. J. Physiol. Renal Physiol. 287 (4): F649–57. doi:10.1152/ajprenal.00028.2004. PMID   15198927.
• Lee HJ, Cho CH, Hwang SJ, et al. (2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200–8. doi: 10.1096/fj.03-1466com . PMID   15284220. S2CID   19001234.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Oliner J, Min H, Leal J, et al. (2004). "Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2". Cancer Cell. 6 (5): 507–16. doi: 10.1016/j.ccr.2004.09.030 . PMID   15542434.
• Olsen MW, Ley CD, Junker N, et al. (2006). "Angiopoietin-4 Inhibits Angiogenesis and Reduces Interstitial Fluid Pressure". Neoplasia. 8 (5): 364–72. doi:10.1593/neo.06127. PMC   1592453 . PMID   16790085.