Fluoroacetyl-CoA thioesterase

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Fluoroacetyl-CoA thioesterase
Identifiers
EC no. 3.1.2.29
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The enzyme fluoroacetyl-CoA thioesterase (EC 3.1.2.29; systematic name fluoroacetyl-CoA hydrolase) catalyses the following reaction: [1] [2] [3]

fluoroacetyl-CoA + H2O fluoroacetate + CoA

Fluoroacetate is extremely toxic.

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References

  1. Meyer JJ, Grobbelaar N, Vleggaar R, Louw AI (1992). "Fluoroacetyl-coenzyme-A hydrolase-like activity in Dichapetalum cymosum". J. Plant Physiol. 139 (3): 369–372. doi:10.1016/s0176-1617(11)80352-4.
  2. Huang F, Haydock SF, Spiteller D, Mironenko T, Li TL, O'Hagan D, Leadlay PF, Spencer JB (May 2006). "The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A". Chemistry & Biology. 13 (5): 475–84. doi:10.1016/j.chembiol.2006.02.014. PMID   16720268.
  3. Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL (July 2010). "Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK". The Journal of Biological Chemistry. 285 (29): 22495–504. doi: 10.1074/jbc.m110.107177 . PMC   2903362 . PMID   20430898.