Ivonescimab

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Ivonescimab
Monoclonal antibody
Type ?
Source Humanized (from hamster)
Target PD-1, VEGF-A
Clinical data
Other namesAK112
Pharmacokinetic data
Elimination half-life 6-7 days
Identifiers
CAS Number
PubChem SID
DrugBank
UNII

Ivonescimab is a humanized bispecific monoclonal antibody currently being trialed for use against non-small-cell lung cancer. Developed by Akeso Biopharma, it has been approved in China for the treatment of epidermal growth factor receptor-mutated locally advanced or metastatic non-squamous NSCLC in patients who have progressed past tyrosine kinase inhibitor therapy, [1] and is undergoing clinical trials elsewhere.

Contents

Mechanism of action

Ivonescimab prevents tumor proliferation and angiogenesis by inhibiting programmed cell death protein 1 and vascular endothelial growth factor A, respectively. [2]

Research

Ivonescimab so far has only completed trials in Chinese patients, [3] and is currently undergoing phase III trials in the United States for the treatment of non-squamous non-small-cell lung cancer and advanced NSCLC. [4]

Society and culture

The initial success of ivonescimab in trials is compared to already-approved drugs such as Merck & Co.'s Keytruda (pembrolizumab); its success has been described as important for the pharmaceutical industry in China. [5]

See also

References

  1. "国家药监局批准依沃西单抗注射液上市". 国家药品监督管理局 (National Medical Products Administration) (in Chinese). 24 May 2024. Retrieved 6 March 2025.
  2. Zhong TT, Huang ZL, Pang XH, et al. (November 2023). "1194 Mechanism of action of ivonescimab (AK112/SMT112): a first-in-class tetravalent Fc-silent bispecific antibody with dual blockade of PD-1 and VEGF that promotes cooperative biological effects". Journal for Immunotherapy of Cancer. 11: A1316 –A1317. doi: 10.1136/jitc-2023-SITC2023.1194 .
  3. Helwick V (25 September 2024). "HARMONi-2: Ivonescimab Outperforms Pembrolizumab as First-Line Treatment in NSCLC". The ASCO Post . Retrieved 1 March 2025.
  4. Dhillon S (September 2024). "Ivonescimab: First Approval". Drugs . 84 (9): 1135–1142. doi: 10.1007/s40265-024-02073-w . PMID   39073550.
  5. Chang W, Ripley W, Cheung E (25 February 2025). "A little-known Chinese company made a drug that beat the world's biggest-selling medicine". CNN . Retrieved 1 March 2025.