This is a detailed list of human spaceflights from 1991 to 2000, including the continuation of Russian space station Mir and the American Space Shuttle program, and the first flights to the International Space Station (ISS).
The Soviet Union broke up at the end of 1991. From this date onwards the former USSR constituent republics are shown as separate nationalities.
| # | Crew | Launch spacecraft | Habitation | Return spacecraft | Brief mission summary | |
|---|---|---|---|---|---|---|
| 141 |  Steven R. Nagel (3) Kenneth D. Cameron (1) Jerry L. Ross (3) Jerome Apt (1) Linda M. Godwin (1) | 5 April 1991 STS-37, Atlantis | 11 April 1991 STS-37, Atlantis | Deployment of Compton Gamma Ray Observatory. | ||
| 142 | Michael L. Coats (3) L. Blaine Hammond (1) Guion S. Bluford (3) Gregory J. Harbaugh (1) Richard J. Hieb (1) Donald R. McMonagle (1) Charles L. Veach (1) | 28 April 1991 STS-39, Discovery | 6 May 1991 STS-39, Discovery | U.S. Department of Defense mission. Part-classified payload, including various science experiments and observations. | ||
| 143 |  Helen Sharman | 18 May 1991 Soyuz TM-12 | Mir | 26 May 1991 Soyuz TM-11 | Mir crew rotation. Life science experiments. First Briton in space (Sharman). First European woman in space (Sharman). | |
| Anatoli Artsebarsky | 10 October 1991 Soyuz TM-12 | |||||
| Sergei Krikalev (2) | 25 March 1992 Soyuz TM-13 | |||||
| 144 | Bryan D. O'Connor (2) Sidney M. Gutierrez (1) James P. Bagian (2) Tamara E. Jernigan (1) M. Rhea Seddon (2) F. Drew Gaffney Millie E. Hughes-Fulford | 5 June 1991 STS-40, Columbia | 14 June 1991 STS-40, Columbia | Spacelab life sciences mission, studying humans, rodents and jellyfish. | ||
| 145 | John E. Blaha (3) Michael A. Baker (1) Shannon W. Lucid (3) James C. Adamson (2) G. David Low (2) | 2 August 1991 STS-43, Atlantis | 11 August 1991 STS-43, Atlantis | Deployment of Tracking and Data Relay Satellite-5. | ||
| 146 | John O. Creighton (3) Kenneth S. Reightler (1) James F. Buchli (4) Charles D. Gemar (2) Mark N. Brown (2) | 12 September 1991 STS-48, Discovery | 18 September 1991 STS-48, Discovery | Deployment of Upper Atmosphere Research Satellite (UARS). | ||
| 147 | Toktar Aubakirov  Franz Viehböck | 2 October 1991 Soyuz TM-13 | Mir | 10 October 1991 Soyuz TM-12 | Mir crew rotation. First Kazakh in space (Aubakirov). First Austrian in space (Viehböck). | |
| Aleksandr Volkov (3) | 25 March 1992 Soyuz TM-13 | |||||
| 148 | Frederick D. Gregory (3) Terence T. Henricks (1) F. Story Musgrave (4) Mario Runco (1) James S. Voss (1) Thomas J. Hennen | 24 November 1991 STS-44, Atlantis | 1 December 1991 STS-44, Atlantis | U.S. Department of Defense mission. Deployment of Defense Support Program (DSP) satellite. | ||
| 149 | Ronald J. Grabe (3) Stephen S. Oswald (1) Norman E. Thagard (4) David C. Hilmers (4) William F. Readdy (1) Roberta L. Bondar  Ulf Merbold (2) | 22 January 1992 STS-42, Discovery | 30 January 1992 STS-42, Discovery | International Microgravity Laboratory-1 (IML-1). Life sciences and materials processing experiments. First Canadian woman in space (Bondar). | ||
| 150 | Klaus-Dietrich Flade | 17 March 1992 Soyuz TM-14 | Mir | 25 March 1992 Soyuz TM-13 | First Soyuz mission since the collapse of the USSR. | |
| Aleksandr Viktorenko (3) Aleksandr Kaleri (1) | 10 August 1992 Soyuz TM-14 | |||||
| 151 | Charles F. Bolden (3) Brian Duffy (1) Kathryn D. Sullivan (3) David C. Leestma (3) C. Michael Foale (1) Byron K. Lichtenberg (2) Dirk Frimout | 24 March 1992 STS-45, Atlantis | 2 April 1992 STS-45, Atlantis | Atmospheric Laboratory for Applications and Science (ATLAS-1): international experiments in atmospheric and astronomical research. First Belgian in space (Frimout). | ||
| 152 | Daniel C. Brandenstein (4) Kevin P. Chilton (1) Pierre J. Thuot (2) Kathryn C. Thornton (2) Richard J. Hieb (2) Thomas D. Akers (2) Bruce E. Melnick (2) | 7 May 1992 STS-49, Endeavour | 16 May 1992 STS-49, Endeavour | Retrieval and redeployment of INTELSAT VI (F-3) satellite. Demonstration of maintenance and assembly capabilities for Space Station Freedom. | ||
| 153 | Richard N. Richards (3) Kenneth D. Bowersox (1) Bonnie J. Dunbar (3) Lawrence J. DeLucas Ellen S. Baker (2) Carl J. Meade (2) Eugene H. Trinh | 25 June 1992 STS-50, Columbia | 9 July 1992 STS-50, Columbia | United States Microgravity Laboratory-I (USML-1): various microgravity experiments. | ||
| 154 |  Michael Tognini (1) | 27 July 1992 Soyuz TM-15 | Mir | 10 August 1992 Soyuz TM-14 | Mir crew rotation. | |
| Anatoly Solovyev (3) Sergei Avdeyev (1) | 1 February 1993 Soyuz TM-15 | |||||
| 155 | Loren J. Shriver (3) Andrew M. Allen (1) Jeffrey A. Hoffman (3) Franklin R. Chang-Diaz (3) Claude Nicollier (1) Marsha S. Ivins (2) Franco Malerba | 31 July 1992 STS-46, Atlantis | 8 August 1992 STS-46, Atlantis | Deployment of ESA's EURECA (European Retrievable Carrier). Deployment of joint NASA/Italian Space Agency Tethered Satellite System (TSS) (failed). First Swiss in space (Nicollier). First Italian in space (Malerba). | ||
| 156 | Robert L. Gibson (4) Curtis L. Brown (1) Mark C. Lee (2) N. Jan Davis (1) Jerome Apt (2) Mae C. Jemison  Mamoru Mohri (1) | 12 September 1992 STS-47, Endeavour | 20 September 1992 STS-47, Endeavour | 50th Space Shuttle mission. Joint NASA and NASDA mission. Conducted microgravity investigations in materials and life sciences. First African-American woman in space (Jemison). | ||
| 157 | James B. Wetherbee (2) Michael A. Baker (2) Charles L. Veach (2) William M. Shepherd (3) Tamara E. Jernigan (2) Steven G. MacLean (1) | 22 October 1992 STS-52, Columbia | 1 November 1992 STS-52, Columbia | Deployment of Laser Geodynamic Satellite II (LAGEOS-II). US Microgravity Payload-1 (USMP-1): physics experiments. | ||
| 158 | David M. Walker (3) Robert D. Cabana (2) Guion S. Bluford (4) James S. Voss (2) Michael R. Clifford (1) | 2 December 1992 STS-53, Discovery | 9 December 1992 STS-53, Discovery | Classified US Department of Defense primary payload, reportedly a reconnaissance satellite. Miscellaneous unclassified science experiments. | ||
| 159 | John H. Casper (2) Donald R. McMonagle (2) Mario Runco (2) Gregory J. Harbaugh (2) Susan J. Helms (1) | 13 January 1993 STS-54, Endeavour | 19 January 1993 STS-54, Endeavour | Deployment of fifth Tracking and Data Relay Satellite (TDRS-F). Diffuse X-ray Spectrometer (DXS) and microgravity experiments. | ||
| 160 | Gennadi Manakov (2) Aleksandr Poleshchuk | 24 January 1993 Soyuz TM-16 | Mir | 22 July 1993 Soyuz TM-16 | Docking system tests. | |
| 161 | Kenneth D. Cameron (2) Stephen S. Oswald (2) C. Michael Foale (2) Kenneth D. Cockrell (1) Ellen L. Ochoa (1) | 8 April 1993 STS-56, Discovery | 17 April 1993 STS-56, Discovery | Atmospheric Laboratory for Applications and Science-2 (ATLAS-2). Atmospheric and solar science research. | ||
| 162 | Steven R. Nagel (4) Terence T. Henricks (2) Jerry L. Ross (4) Charles J. Precourt (1) Bernard A. Harris (1) Ulrich Walter Hans Schlegel (1) | 26 April 1993 STS-55, Columbia | 6 May 1993 STS-55, Columbia | German-sponsored Spacelab flight: miscellaneous science experiments. | ||
| 163 | Ronald J. Grabe (4) Brian Duffy (2) G. David Low (3) Nancy J. Sherlock Currie (1) Peter J. Wisoff (1) Janice E. Voss (1) | 21 June 1993 STS-57, Endeavour | 1 July 1993 STS-57, Endeavour | First SPACEHAB flight: biomedical and materials sciences experiments. Retrieval of ESA's EURECA (European Retrievable Carrier). | ||
| 164 | Jean-Pierre Haigneré (1) | 1 July 1993 Soyuz TM-17 | Mir | 22 July 1993 Soyuz TM-16 | Mir crew rotation. | |
| Vasili Tsiblyev (1) Aleksandr Serebrov (4) | 13 January 1994 Soyuz TM-17 | |||||
| 165 | Frank L. Culbertson (2) William F. Readdy (2) James H. Newman (1) Daniel W. Bursch (1) Carl E. Walz (1) | 12 September 1993 STS-51, Discovery | 22 September 1993 STS-51, Discovery | Deployment of Advanced Communications Technology Satellite (ACTS). Ultraviolet astronomical observations. | ||
| 166 | John E. Blaha (4) Richard A. Searfoss (1) M. Rhea Seddon (3) William S. McArthur (1) David A. Wolf (1) Shannon W. Lucid (4) Martin J. Fettman | 18 October 1993 STS-58, Columbia | 1 November 1993 STS-58, Columbia | Spacelab life sciences mission. | ||
| 167 | Richard O. Covey (4) Kenneth D. Bowersox (2) F. Story Musgrave (5) Kathryn C. Thornton (3) Claude Nicollier (2) Jeffrey A. Hoffman (4) Thomas D. Akers (3) | 2 December 1993 STS-61, Endeavour | 13 December 1993 STS-61, Endeavour | First Hubble Space Telescope repair servicing mission. | ||
| 168 | Viktor Afanasyev (2) Yuri Usachyev (1) | 8 January 1994 Soyuz TM-18 | Mir | 9 July 1994 Soyuz TM-18 | Mir crew rotation. | |
| Valeri Polyokov (2) | 22 March 1995 Soyuz TM-20 | |||||
| 169 | Charles F. Bolden (4) Kenneth S. Reightler (2) N. Jan Davis (2) Ronald M. Sega (1) Franklin R. Chang-Diaz (4) Sergei Krikalev (3) | 3 February 1994 STS-60, Discovery | 11 February 1994 STS-60, Discovery | SPACEHAB-2: materials science and life sciences investigations. Wake Shield Facility-1 deployment. Medical and radiological investigations. First Russian to fly aboard the Space Shuttle (Krikalev). | ||
| 170 | John H. Casper (3) Andrew M. Allen (2) Pierre J. Thuot (3) Charles D. Gemar (3) Marsha S. Ivins (3) | 4 March 1994 STS-62, Columbia | 18 March 1994 STS-62, Columbia | Miscellaneous scientific experiments. | ||
| 171 | Sidney M. Gutierrez (2) Kevin P. Chilton (2) Linda M. Godwin (2) Jerome Apt (3) Michael R. Clifford (2) Thomas D. Jones (1) | 9 April 1994 STS-59, Endeavour | 20 April 1994 STS-59, Endeavour | Radar mapping of Earth and atmospheric research. | ||
| 172 | Yuri Malenchenko (1) Talgat Musabayev (1) | 3 July 1994 Soyuz TM-19 | Mir | 4 November 1994 Soyuz TM-19 | Medical and materials science experiments. Mir repairs. | |
| 173 | Robert D. Cabana (3) James D. Halsell (1) Richard J. Hieb (3) Carl E. Walz (2) Leroy Chiao (1) Donald A. Thomas (1) Chiaki Naito-Mukai (1) | 8 July 1994 STS-65, Columbia | 23 July 1994 STS-65, Columbia | International Microgravity Laboratory-2: miscellaneous microgravity experiments. First Japanese woman in space (Naito-Mukai). | ||
| 174 | Richard N. Richards (4) L. Blaine Hammond (2) Jerry M. Linenger (1) Susan J. Helms (2) Carl J. Meade (3) Mark C. Lee (3) | 9 September 1994 STS-64, Discovery | 20 September 1994 STS-64, Discovery | Atmospheric and solar observations. | ||
| 175 | Michael A. Baker (3) Terrence W. Wilcutt (1) Thomas D. Jones (2) Steven L. Smith (1) Daniel W. Bursch (2) Peter J.K. Wisoff (2) | 30 September 1994 STS-68, Endeavour | 11 October 1994 STS-68, Endeavour | Radar imaging of Earth. | ||
| 176 | Ulf Merbold (3) | 4 October 1994 Soyuz TM-20 | Mir | 4 November 1994 Soyuz TM-19 | Mir crew rotation. | |
| Aleksandr Viktorenko (4) Yelena Kondakova (1) | 22 March 1995 Soyuz TM-20 | |||||
| 177 | Donald R. McMonagle (3) Curtis L. Brown (2) Ellen L. Ochoa (2) Scott E. Parazynski (1) Joseph R. Tanner (1) Jean-François Clervoy (1) | 3 November 1994 STS-66, Atlantis | 14 November 1994 STS-66, Atlantis | Atmospheric research. | ||
| 178 | James D. Wetherbee (3) Eileen M. Collins (1) C. Michael Foale (3) Janice E. Voss (2) Bernard A. Harris (2) Vladimir G. Titov (3) | 3 February 1995 STS-63, Discovery | 11 February 1995 STS-63, Discovery | Rendezvous maneuver with Mir. First female pilot (Collins). SPACEHAB-3: miscellaneous science experiments. First EVA by an African-American astronaut (Harris). | ||
| 179 | Stephen S. Oswald (3) William G. Gregory Tamara E. Jernigan (3) John M. Grunsfeld (1) Wendy B. Lawrence (1) Ronald A. Parise (2) Samuel T. Durrance (2) | 2 March 1995 STS-67, Endeavour | 18 March 1995 STS-67, Endeavour | Ultraviolet astronomy studies. | ||
| 180 | Norman E. Thagard (5) Vladimir Dezhurov (1) Gennady Strekalov (5) | 14 March 1995 Soyuz TM-21 | Mir | 7 July 1995 STS-71, Atlantis | First American to visit Mir (Thagard). | |
| 181 | Robert L. Gibson (5) Charles J. Precourt (2) Ellen S. Baker (3) Bonnie J. Dunbar (4) Gregory J. Harbaugh (3) | 27 June 1995 STS-71, Atlantis | Mir | 7 July 1995 STS-71, Atlantis | First Shuttle-Mir docking. Biomedical experiments. Mir crew rotation and resupply. | |
| Anatoly Solovyev (4) Nikolai Budarin (1) | 11 September 1995 Soyuz TM-21 | |||||
| 182 | Terence T. Henricks (3) Kevin R. Kregel (1) Nancy J. Sherlock Currie (2) Donald A. Thomas (2) Mary E. Weber (1) | 13 July 1995 STS-70, Discovery | 22 July 1995 STS-70, Discovery | Deployment of 7th Tracking and Data Relay Satellite (TDRS). Biological and biomedical studies. | ||
| 183 | Sergei Avdeyev (2) Yuri Ghidzenko (1) Thomas Reiter (1) | 3 September 1995 Soyuz TM-22 | Mir | 29 February 1996 Soyuz TM-22 | Mir crew rotation. First EVA by a German cosmonaut (Reiter). | |
| 184 | David M. Walker (4) Kenneth D. Cockrell (2) James S. Voss (3) James H. Newman (2) Michael L. Gernhardt (1) | 7 September 1995 STS-69, Endeavour | 18 September 1995 STS-69, Endeavour | Solar observations. Wake Shield Facility-2 deployment. | ||
| 185 | Kenneth D. Bowersox (3) Kent V. Rominger (1) Kathryn C. Thornton (4) Catherine G. Coleman (1) Michael E. Lopez-Alegria (1) Fred W. Leslie Albert Sacco | 20 October 1995 STS-73, Columbia | 5 November 1995 STS-73, Columbia | Microgravity experiments. | ||
| 186 | Kenneth D. Cameron (3) James D. Halsell (2) Jerry L. Ross (5) William S. McArthur (2) Chris A. Hadfield (1) | 12 November 1995 STS-74, Atlantis | Mir | 20 November 1995 STS-74, Atlantis | Second Shuttle-Mir docking. Delivery of Russian docking module and solar arrays. | |
| 187 | Brian Duffy (3) Brent W. Jett (1) Leroy Chiao (2) Daniel T. Barry (1) Winston E. Scott (1) Koichi Wakata (1) | 11 January 1996 STS-72, Endeavour | 20 January 1996 STS-72, Endeavour | Capture and return to Earth of Space Flyer Unit (Japanese microgravity research spacecraft). | ||
| 188 | Yuri Onufrienko (1) Yuri Usachyev (2) | 21 February 1996 Soyuz TM-23 | Mir | 2 September 1996 Soyuz TM-23 | ||
| 189 | Andrew M. Allen (3) Scott J. Horowitz (1) Franklin R. Chang-Diaz (5) Maurizio Cheli Jeffrey A. Hoffman (5) Claude Nicollier (3) Umberto Guidoni (1) | 22 February 1996 STS-75, Columbia | 9 March 1996 STS-75, Columbia | Deployment of Tethered Satellite System (TSS-1R) (reflight, partial success). Microgravity research. | ||
| 190 | Kevin P. Chilton (3) Richard A. Searfoss (2) Linda M. Godwin (3) Michael R. Clifford (3) Ronald M. Sega (2) | 22 March 1996 STS-76, Atlantis | Mir | 31 March 1996 STS-76, Atlantis | Mir crew rotation and resupply. First American woman on Mir (Lucid). | |
| Shannon W. Lucid (5) | 26 September 1996 STS-79, Atlantis | |||||
| 191 | John H. Casper (4) Curtis L. Brown (3) Daniel W. Bursch (3) Mario Runco, Jr. (3) J. Marc Garneau (2) Andrew S.W. Thomas (1) | 19 May 1996 STS-77, Endeavour | 29 May 1996 STS-77, Endeavour | SPACEHAB-4: miscellaneous science experiments. Deployment of Spartan-207/IAE (Inflatable Antenna Experiment) satellite. Rendezvous with experimental satellite. | ||
| 192 | Terence T. Henricks (4) Kevin R. Kregel (2) Susan J. Helms (3) Richard M. Linnehan (1) Charles E. Brady Jean-Jacques Favier Robert B. Thirsk (1) | 20 June 1996 STS-78, Columbia | 7 July 1996 STS-78, Columbia | Microgravity, human physiology and life sciences research. | ||
| 193 | Claudie Haigneré (1) | 18 August 1996 Soyuz TM-24 | Mir | 2 September 1996 Soyuz TM-23 | Mir crew rotation. Biological and medical experiments. First Frenchwoman in space (Andre-Deshays). | |
| Valery Korzun (1) Aleksandr Kaleri (2) | 2 March 1997 Soyuz TM-24 | |||||
| 194 | William F. Readdy (3) Terrence W. Wilcutt (2) Thomas D. Akers (4) Jerome Apt (4) Carl E. Walz (3) | 16 September 1996 STS-79, Atlantis | Mir | 26 September 1996 STS-79, Atlantis | Mir crew rotation and resupply. Miscellaneous scientific experiments. | |
| John E. Blaha (5) | 22 January 1997 STS-81, Atlantis | |||||
| 195 | Kenneth D. Cockrell (3) Kent V. Rominger (2) Tamara E. Jernigan (4) Thomas D. Jones (3) F. Story Musgrave (6) | 19 November 1996 STS-80, Columbia | 7 December 1996 STS-80, Columbia | Deployment and retrieval of Wake Shield Facility and German-built Orbiting and Retrievable Far and Extreme Ultraviolet Spectrograph-Shuttle Pallet Satellite II (ORFEUS-SPAS II). | ||
| 196 | Michael A. Baker (4) Brent W. Jett (2) John M. Grunsfeld (2) Marsha S. Ivins (4) Peter J.K. Wisoff (3) | 12 January 1997 STS-81, Atlantis | Mir | 22 January 1997 STS-81, Atlantis | Mir crew rotation and resupply. | |
| Jerry M. Linenger (2) | 24 May 1997 STS-84, Atlantis | |||||
| 197 | Reinhold Ewald | 10 February 1997 Soyuz TM-25 | Mir | 2 March 1997 Soyuz TM-24 | Mir crew rotation and resupply. | |
| Vasili Tsibliev (2) Aleksandr Lazutkin | 14 August 1997 Soyuz TM-25 | |||||
| 198 | Kenneth D. Bowersox (4) Scott J. Horowitz (2) Mark C. Lee (4) Steven A. Hawley (4) Gregory J. Harbaugh (4) Steven L. Smith (2) Joseph R. Tanner (2) | 11 February 1997 STS-82, Discovery | 21 February 1997 STS-82, Discovery | Hubble Space Telescope servicing mission. | ||
| 199 | James D. Halsell (3) Susan L. Still (1) Janice E. Voss (3) Donald A. Thomas (3) Michael L. Gernhardt (2) Roger K. Crouch (1) Gregory T. Linteris (1) | 4 April 1997 STS-83, Columbia | 8 April 1997 STS-83, Columbia | Microgravity experiments. Mission cut short due to fuel cell problems. | ||
| 200 | Charles J. Precourt (3) Eileen M. Collins (2) Jean-François Clervoy (2) Carlos I. Noriega (1) Edward T. Lu (1) Yelena Kondakova (2) | 15 May 1997 STS-84, Atlantis | Mir | 24 May 1997 STS-84, Atlantis | Mir crew rotation and resupply. First joint US-Russian space walk. | |
| C. Michael Foale (4) | 6 October 1997 STS-86, Atlantis | |||||
| 201 | James D. Halsell (4) Susan L. Still (2) Janice E. Voss (4) Donald A. Thomas (4) Michael L. Gernhardt (3) Roger K. Crouch (2) Gregory T. Linteris (2) | 1 July 1997 STS-94, Columbia | 17 July 1997 STS-94, Columbia | Microgravity experiments. Reflight of curtailed STS-83 mission. | ||
| 202 | Anatoly Solovyev (5) Pavel Vinogradov (1) | 6 August 1997 Soyuz TM-26 | Mir | 19 February 1998 Soyuz TM-26 | Mir repair. | |
| 203 | Curtis L. Brown (4) Kent V. Rominger (3) N. Jan Davis (3) Robert L. Curbeam (1) Stephen K. Robinson (1) Bjarni V. Tryggvason | 7 August 1997 STS-85, Discovery | 19 August 1997 STS-85, Discovery | Atmospheric research. | ||
| 204 | James D. Wetherbee (4) Michael J. Bloomfield (1) Vladimir Titov (4) Scott E. Parazynski (2) Jean-Loup Chrétien (3) Wendy B. Lawrence (2) | 25 September 1997 STS-86, Atlantis | Mir | 6 October 1997 STS-86, Atlantis | Mir crew rotation and resupply. | |
| David A. Wolf (2) | 31 January 1998 STS-89, Endeavour | |||||
| 205 | Kevin R. Kregel (3) Steven W. Lindsey (1) Winston E. Scott (2) Kalpana Chawla (1) Takao Doi (1) Leonid Kadeniuk | 19 November 1997 STS-87, Columbia | 5 December 1997 STS-87, Columbia | Miscellaneous scientific experiments. First Japanese EVA (Doi). First Ukrainian in space (Kadenyuk). | ||
| 206 | Terrence W. Wilcutt (3) Joe F. Edwards Bonnie J. Dunbar (5) Michael P. Anderson (1) James F. Reilly (1) Salizhan Sharipov (1) | 22 January 1998 STS-89, Endeavour | Mir | 31 January 1998 STS-89, Endeavour | Mir crew rotation and resupply. | |
| Andrew S.W. Thomas (2) | 12 June 1998 STS-91, Discovery | |||||
| 207 | Léopold Eyharts (1) | 29 January 1998 Soyuz TM-27 | Mir | 19 February 1998 Soyuz TM-26 | Mir crew rotation. | |
| Talgat Musabayev (2) Nikolai Budarin (2) | 25 August 1998 Soyuz TM-27 | |||||
| 208 | Richard A. Searfoss (3) Scott D. Altman (1) Richard M. Linnehan (2) Dafydd R. Williams (1) Kathryn P. Hire (1) Jay C. Buckley James A. Pawelzyk | 17 April 1998 STS-90, Columbia | 3 May 1998 STS-90, Columbia | Neuroscience research. Final Spacelab mission. | ||
| 209 | Charles J. Precourt (4) Dominic L. Pudwill Gorie (1) Wendy B. Lawrence (3) Franklin R. Chang-Diaz (6) Janet L. Kavandi (1) Valery Ryumin (4) | 2 June 1998 STS-91, Discovery | Mir | 12 June 1998 STS-91, Discovery | Final Shuttle-Mir docking. Mir crew rotation and resupply. Astrophysics research. | |
| 210 | Yuri Baturin (1) | 15 August 1998 Soyuz TM-28 | Mir | 25 August 1998 Soyuz TM-27 | Mir crew rotation. | |
| Gennady Padalka (1) | 28 February 1999 Soyuz TM-28 | |||||
| Sergei Avdeyev (3) | 28 August 1999 Soyuz TM-29 | |||||
| 211 | Curtis L. Brown (5) Steven W. Lindsey (2) Scott E. Parazynski (3) Stephen K. Robinson (2) Pedro Duque (1) Chiaki Mukai (2) John H. Glenn (2) | 29 October 1998 STS-95, Discovery | 7 November 1998 STS-95, Discovery | Miscellaneous scientific experiments. First Spaniard in space (Duque). Veteran John Glenn returned to space aged 77. | ||
| 212 | Robert D. Cabana (4) Frederick W. Sturckow (1) Nancy J. Sherlock Currie (3) Jerry L. Ross (6) James H. Newman (3) Sergei Krikalev (4) | 4 December 1998 STS-88, Endeavour | ISS | 15 December 1998 STS-88, Endeavour | First ISS construction mission. Delivery of Unity Node Module. | |
| 213 |  Ivan Bella | 20 February 1999 Soyuz TM-29 | Mir | 28 February 1999 Soyuz TM-28 | Mir crew rotation. First Slovak in space (Bella). | |
| Viktor Afanasyev (3) Jean-Pierre Haigneré (2) | 28 August 1999 Soyuz TM-29 | |||||
| 214 | Kent V. Rominger (4) Rick D. Husband (1) Ellen L. Ochoa (3) Tamara E. Jernigan (5) Daniel T. Barry (2) Julie Payette (1) Valery Tokarev (1) | 27 May 1999 STS-96, Discovery | ISS | 6 June 1999 STS-96, Discovery | Second ISS flight. ISS assembly and resupply. | |
| 215 | Eileen M. Collins (3) Jeffrey S. Ashby (1) Steven A. Hawley (5) Catherine G. Coleman (2) Michel Tognini (2) | 23 July 1999 STS-93, Columbia | 27 July 1999 STS-93, Columbia | Deployment of Chandra X-ray Observatory. First female Shuttle Commander (Collins). | ||
| 216 | Curtis L. Brown (6) Scott J. Kelly (1) Steven L. Smith (3) C. Michael Foale (5) John M. Grunsfeld (3) Claude Nicollier (4) Jean-François Clervoy (3) | 19 December 1999 STS-103, Discovery | 27 December 1999 STS-103, Discovery | Hubble Space Telescope servicing. | ||
| 217 | Kevin R. Kregel (4) Dominic L. Pudwill Gorie (2) Janet L. Kavandi (2) Janice E. Voss (5) Mamoru Mohri (2) Gerhard Thiele | 11 February 2000 STS-99, Endeavour | 22 February 2000 STS-99, Endeavour | Radar topographic mapping of Earth's surface. | ||
| 218 | Sergei Zalyotin (1) Aleksandr Kaleri (3) | 4 April 2000 Soyuz TM-30 | Mir | 16 June 2000 Soyuz TM-30 | Mir repairs. 39th and final Mir mission. | |
| 219 | James D. Halsell (5) Scott J. Horowitz (3) Mary E. Weber (2) Jeffrey N. Williams (1) James S. Voss (4) Susan J. Helms (4) Yuri Usachev (3) | 19 May 2000 STS-101, Atlantis | ISS | 29 May 2000 STS-101, Atlantis | ISS construction and supply. | |
| 220 | Terrence W. Wilcutt (4) Scott D. Altman (2) Daniel C. Burbank (1) Edward T. Lu (2) Richard A. Mastracchio (1) Yuri Malenchenko (2) Boris Morukov | 8 September 2000 STS-106, Atlantis | ISS | 19 September 2000 STS-106, Atlantis | ISS supply. Preparation for first long-term crew. | |
| 221 | Brian Duffy (4) Pamela A. Melroy (1) Koichi Wakata (2) Leroy Chiao (3) Peter J.K. Wisoff (4) Michael E. Lopez-Alegria (2) William S. McArthur (3) | 11 October 2000 STS-92, Discovery | ISS | 24 October 2000 STS-92, Discovery | ISS construction and outfitting. 100th Space Shuttle mission. | |
| 222 | Yuri Gidzenko (2) Sergei Krikalev (5) William M. Shepherd (4) | 31 October 2000 Soyuz TM-31 | ISS (crew 1) | 21 March 2001 STS-102, Discovery | First ISS Expedition Crew. | |
| 223 | Brent W. Jett (3) Michael J. Bloomfield (2) Joseph R. Tanner (3) J. Marc Garneau (3) Carlos I. Noriega (2) | 30 November 2000 STS-97, Endeavour | ISS | 11 December 2000 STS-97, Endeavour | ISS construction and supply. Delivery of the first set of solar arrays and batteries. | |
