Noravizafone desglycyl

Last updated

Noravizafone desglycyl
Noravizafone-desglycyl structure.png
Identifiers
  • 2-amino-N-(2-benzoyl-4-chlorophenyl)acetamide
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C15H13ClN2O2
Molar mass 288.73 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)C(=O)C2=C(C=CC(=C2)Cl)NC(=O)CN
  • InChI=1S/C15H13ClN2O2/c16-11-6-7-13(18-14(19)9-17)12(8-11)15(20)10-4-2-1-3-5-10/h1-8H,9,17H2,(H,18,19)
  • Key:GIBRATRQHFFRHE-UHFFFAOYSA-N

Noravizafone desglycyl is a chemical compound that can act as both a prodrug and a synthetic precursor for the benzodiazepine derivative nordiazepam, as well as forming as a breakdown product of nordiazepam during storage under certain conditions. It is inactive in vitro but has similar effects to nordiazepam in vivo due to metabolic conversion to the active benzodiazepine form. It has been detected as a designer drug, first being identified in Germany in September 2024. [1] [2] [3]

See also

References

  1. ↑ Gall M, Hester JB, Rudzik AD, Lahti RA (August 1976). "Synthesis and pharmacology of novel anxiolytic agents derived from 2-[(dialkylamino)methyl-4H-triazol-4-yl] benzophenones and related heterocyclic benzophenones". Journal of Medicinal Chemistry. 19 (8): 1057–1064. doi:10.1021/jm00230a016. PMID   9511.
  2. ↑ Barclay VK, Tyrefors NL, Johansson IM, Pettersson CE (July 2019). "Acidic transformation of nordiazepam can affect recovery estimate during trace analysis of diazepam and nordiazepam in environmental water samples by liquid chromatography-tandem mass spectrometry". Analytical and Bioanalytical Chemistry. 411 (17): 3919–3928. doi:10.1007/s00216-019-01870-7. PMC   6594989 . PMID   31104085.
  3. ↑ "European Drug Report 2025 – Full Book" (PDF). European Union Drugs Agency (euda.europa.eu). 6 June 2025.
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