Sodium astatide

Last updated
Sodium astatide
Na+.svg
At-.svg
Names
Preferred IUPAC name
Sodium astatide
Identifiers
3D model (JSmol)
PubChem CID
  • InChI=1S/At.Na/q-1;+1
    Key: AXOFGGQEXCHHCD-UHFFFAOYSA-N
  • [Na+].[At-]
Properties
NaAt
Molar mass 233 g·mol−1
Melting point 518 °C (964 °F; 791 K) calculated [1]
Thermochemistry
−257 kJ/mol (estimated) [2]
Related compounds
Related compounds
 Magnesium astatide
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Sodium astatide is a binary inorganic compound, a salt of sodium and astatine with the chemical formula NaAt. [3] [4]

Contents

Synthesis

Sodium astatide solution has been prepared by distilling astatine from the bismuth alpha-ray target where it was prepared, dissolving in sodium bicarbonate solution, and reducing At+ and At3+ ions with ascorbic acid. [5]

Uses

Sodium astatide has been proposed for use in radiation therapy to replace 131I. [6] [5]

References

  1. ↑ Oshchapovskii, V. V. (2014). "A new method of calculation of the melting temperatures of crystals of Group 1A metal halides and francium metal". Russian Journal of Inorganic Chemistry. 59 (6): 561–567. doi:10.1134/S0036023614060163. ISSN   0036-0236.
  2. ↑ Burgers, Peter C.; Zeneyedpour, Lona; Luider, Theo M.; Holmes, John L. (2024). "Estimation of thermodynamic and physicochemical properties of the alkali astatides: On the bond strength of molecular astatine (At 2 ) and the hydration enthalpy of astatide (At − )". Journal of Mass Spectrometry. 59 (4) e5010. doi: 10.1002/jms.5010 . ISSN   1076-5174. PMID   38488842.
  3. ↑ Watabe, Tadashi; Hosono, Makoto; Kinuya, Seigo; Yamada, Takahiro; Yanagida, Sachiko; Namba, Masao; Nakamura, Yoshihide (July 2021). "Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)". Annals of Nuclear Medicine. 35 (7): 753–766. doi:10.1007/s12149-021-01619-2. ISSN   1864-6433. PMC   8197710 . PMID   33978932.
  4. ↑ Ball, Philip (17 March 2020). "An affinity for astatine". Chemistry World . Retrieved 16 June 2023.
  5. 1 2 Y. Shirakami. "Preparation of [211At]-labeled sodium astatide (NaAt) by reducing with ascorbic acid for the treatment of thyroid cancer" (PDF). RIKEN Accel. Prog. Rep. 53: 171. Retrieved 16 June 2023.
  6. ↑ "Breakthrough alpha-ray treatment of cancer without external radiation". EurekAlert!. Retrieved 16 June 2023.
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