Sodium astatide

Sodium astatide

Names
Preferred IUPAC name Sodium astatide
Identifiers
CAS Number	15194-75-9  Y
3D model (JSmol)	Interactive image
SMILES [Na+].[At-]
Properties
Chemical formula	NaAt
Thermochemistry
Std enthalpy of formation (ΔfH⦵298)	−257 kJ/mol (estimated) [1]
Related compounds
Related compounds	Magnesium astatide
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Sodium astatide is a binary inorganic compound, a salt of sodium and astatine with the chemical formula NaAt. ^{[2] [3]}

Synthesis

Sodium astatide solution has been prepared by distilling astatine from the bismuth alpha-ray target where it was prepared, dissolving in sodium bicarbonate solution, and reducing At⁺ and At³⁺ ions with ascorbic acid. ^[4]

Uses

Sodium astatide has been proposed for use in radiation therapy to replace ¹³¹I. ^{[5] [4]}

References

1. Burgers, Peter C.; Zeneyedpour, Lona; Luider, Theo M.; Holmes, John L. (2024). "Estimation of thermodynamic and physicochemical properties of the alkali astatides: On the bond strength of molecular astatine (At 2 ) and the hydration enthalpy of astatide (At − )". Journal of Mass Spectrometry. 59 (4). doi: 10.1002/jms.5010 . ISSN   1076-5174.
2. Watabe, Tadashi; Hosono, Makoto; Kinuya, Seigo; Yamada, Takahiro; Yanagida, Sachiko; Namba, Masao; Nakamura, Yoshihide (July 2021). "Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)". Annals of Nuclear Medicine. 35 (7): 753–766. doi:10.1007/s12149-021-01619-2. ISSN   1864-6433. PMC   8197710 . PMID   33978932.
3. Ball, Philip (17 March 2020). "An affinity for astatine". Chemistry World . Retrieved 16 June 2023.
4. Y. Shirakami. "Preparation of [211At]-labeled sodium astatide (NaAt) by reducing with ascorbic acid for the treatment of thyroid cancer" (PDF). RIKEN Accel. Prog. Rep. 53: 171. Retrieved 16 June 2023.
5. "Breakthrough alpha-ray treatment of cancer without external radiation". EurekAlert!. Retrieved 16 June 2023.