Combined pulmonary fibrosis and emphysema

Last updated
Combined pulmonary fibrosis and emphysema
Other namesCPFE
Specialty Pulmonology

Combined pulmonary fibrosis and emphysema (CPFE), describes a medical syndrome involving both pulmonary fibrosis and emphysema. [1] [2] The combination is most commonly found in male smokers. Pulmonary function tests typically show preserved lung volume with very low transfer factor. [3]

Contents

Presentation

CFPE is characterised by shortness of breath, and reduced oxygen concentration (reflecting gas exchange abnormalities). Imaging shows upper-lobe emphysema, and lower-lobe interstitial fibrosis. [4] CFPE is often complicated by pulmonary hypertension, acute lung injury, lung cancer, and coronary artery disease. [4]

Diagnosis

The diagnosis is confirmed with high resolution CT scan. [5]

References

  1. ↑ Cottin, V; Cordier JF (June 2005). "Combined pulmonary fibrosis and emphysema: an experimental and clinically relevant phenotype". American Journal of Respiratory and Critical Care Medicine. 172 (12): 1605, author reply 1605–6. doi:10.1164/ajrccm.172.12.1605a. PMID   16339012. Archived from the original on 2011-09-27. Retrieved 2009-02-23.
  2. ↑ Cottin, V; Nunes H; Brillet PY; et al. (February 2006). "Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity". European Respiratory Journal. 26 (4): 586–593. doi: 10.1183/09031936.05.00021005 . PMID   16204587.
  3. ↑ Papiris, SA; Triantafillidou, C; Manali, ED (February 2013). "Combined pulmonary fibrosis and emphysema". Expert Review of Respiratory Medicine. 7 (1): 19–31. doi:10.1586/ers.12.80. PMID   23362797. S2CID   37007269.
  4. 1 2 Wand, O; Kramer, MR (January 2018). "The Syndrome of Combined Pulmonary Fibrosis and Emphysema - CPFE". Harefuah. 157 (1): 28–33. PMID   29374870.
  5. ↑ Jankowich, MD; Rounds, SI (January 2012). "Combined pulmonary fibrosis and emphysema syndrome: a review". Chest. 141 (1): 222–231. doi:10.1378/chest.11-1062. PMC   3251269 . PMID   22215830.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.