PLCD1

PLCD1
Identifiers
Aliases	PLCD1 , NDNC3, PLC-III, phospholipase C delta 1
External IDs	OMIM: 602142 MGI: 97614 HomoloGene: 21252 GeneCards: PLCD1
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p22.2 Start 38,007,496 bp [1] End 38,029,642 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F3 Start 118,900,595 bp [2] End 118,922,570 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb thoracic diaphragm inferior olivary nucleus ascending aorta popliteal artery mucosa of urinary bladder tibial nerve tibia body of tongue cardia Top expressed in esophagus calvaria lip dermal bone body of femur ascending aorta corneal stroma ankle molar mandible More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activating protein binding calcium ion binding phosphatidylinositol phosphate binding phosphatidylserine binding signal transducer activity metal ion binding phosphatidic acid binding phosphoric diester hydrolase activity phospholipase C activity hydrolase activity phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding protein binding Cellular component cytoplasm cytosol plasma membrane extracellular exosome Biological process intracellular signal transduction lipid metabolism labyrinthine layer blood vessel development inositol phosphate metabolic process lipid catabolic process regulation of cell population proliferation angiogenesis phospholipid metabolic process signal transduction inositol trisphosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5333 18799 Ensembl ENSG00000187091 ENSMUSG00000010660 UniProt P51178 Q8R3B1 RefSeq (mRNA) NM_001130964 NM_006225 NM_001293648 NM_019676 RefSeq (protein) NP_001124436 NP_006216 NP_001280577 NP_062650 Location (UCSC) Chr 3: 38.01 – 38.03 Mb Chr 9: 118.9 – 118.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 is an enzyme that in humans is encoded by the PLCD1 gene. ^{[5] [6]} PLCd1 is essential to maintain homeostasis of the skin.

See also

Phospholipase C

References

1. GRCh38: Ensembl release 89: ENSG00000187091 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010660 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa S, Takahashi T, Ogawa M, Nakamura Y (Nov 1997). "Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22→p21.3". Cytogenet Cell Genet. 78 (1): 58–60. doi:10.1159/000134629. PMID   9345909.
6. "Entrez Gene: PLCD1 phospholipase C, delta 1".

Further reading

• Yagisawa H (2006). "Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+". J. Cell. Biochem. 97 (2): 233–43. doi: 10.1002/jcb.20677 . PMID   16240320. S2CID   84240929.
• Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC   329852 . PMID   1979339.
• Zauli G, Previati M, Caramelli E, et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID   7589147. S2CID   20562627.
• Cheng HF, Jiang MJ, Chen CL, et al. (1995). "Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis". J. Biol. Chem. 270 (10): 5495–505. doi: 10.1074/jbc.270.10.5495 . PMID   7890667.
• Ghosh S, Pawelczyk T, Lowenstein JM (1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expr. Purif. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID   9056492.
• Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi: 10.1074/jbc.272.36.22385 . PMID   9278385.
• Park ES, Won JH, Han KJ, et al. (1998). "Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector". Biochem. J. 331 (1): 283–9. doi:10.1042/bj3310283. PMC   1219350 . PMID   9512491.
• Shimohama S, Kamiya S, Fujii M, et al. (1998). "Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function". Biochem. Biophys. Res. Commun. 245 (3): 722–8. doi:10.1006/bbrc.1998.8307. PMID   9588182.
• Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID   9730685. S2CID   19529677.
• Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi: 10.1046/j.1471-4159.1999.0731363.x . PMID   10501179. S2CID   25410140.
• Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi: 10.4049/jimmunol.164.12.6538 . PMID   10843712.
• Nash MS, Young KW, Willars GB, et al. (2001). "Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation". Biochem. J. 356 (Pt 1): 137–42. doi:10.1042/0264-6021:3560137. PMC   1221821 . PMID   11336645.
• Ananthanarayanan B, Das S, Rhee SG, et al. (2002). "Membrane targeting of C2 domains of phospholipase C-delta isoforms". J. Biol. Chem. 277 (5): 3568–75. doi: 10.1074/jbc.M109705200 . PMID   11706040.
• Keshamouni VG, Mattingly RR, Reddy KB (2002). "Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta". J. Biol. Chem. 277 (25): 22558–65. doi: 10.1074/jbc.M202351200 . PMID   11960991.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi: 10.1006/viro.2002.1676 . PMID   12482669.
• Guo Y, Philip F, Scarlata S (2003). "The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site". J. Biol. Chem. 278 (32): 29995–30004. doi: 10.1074/jbc.M301438200 . PMID   12761218.
• Caprini M, Gomis A, Cabedo H, et al. (2003). "GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity". EMBO J. 22 (12): 3004–14. doi:10.1093/emboj/cdg294. PMC   162146 . PMID   12805215.
• Kim JY, Kim H, Lee SG, et al. (2003). "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site". Biochem. Biophys. Res. Commun. 310 (3): 904–9. doi:10.1016/j.bbrc.2003.09.100. PMID   14550290.

External links

• WikiGenes entry for PLCD1