Fight-or-flight response

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Cat and dog standoff (3926784260).jpg
Dog and cat showing fight or flight responses.jpg
A dog and a cat expressing the fight (top) and flight (bottom) response simultaneously

The fight-or-flight or the fight-flight-freeze-or-fawn [1] (also called hyperarousal or the acute stress response) is a physiological reaction that occurs in response to a perceived harmful event, attack, or threat to survival. [2] It was first described by Walter Bradford Cannon in 1915. [a] [3] His theory states that animals react to threats with a general discharge of the sympathetic nervous system, preparing the animal for fighting or fleeing. [4] More specifically, the adrenal medulla produces a hormonal cascade that results in the secretion of catecholamines, especially norepinephrine and epinephrine. [5] The hormones estrogen, testosterone, and cortisol, as well as the neurotransmitters dopamine and serotonin, also affect how organisms react to stress. [6] The hormone osteocalcin might also play a part. [7] [8]

Contents

This response is recognised as the first stage of the general adaptation syndrome that regulates stress responses among vertebrates and other organisms. [9]

Name

Originally understood as the "fight-or-flight" response in Cannon's research, [3] the state of hyperarousal results in several responses beyond fighting or fleeing. This has led people to calling it the "fight, flight, freeze" response, "fight-flight-freeze-fawn" [1] [ citation needed ] or "fight-flight-faint-or-freeze", among other variants. [10]

The wider array of responses, such as freezing, flop, faint, flee and fright, [11] has led researchers to use more neutral or accommodating terminology such as "hyperarousal" or the "acute stress response".

Physiology

Autonomic nervous system

The autonomic nervous system is a control system that acts largely unconsciously and regulates heart rate, digestion, respiratory rate, pupillary response, urination, and sexual arousal. This system is the primary mechanism in control of the fight-or-flight response and its role is mediated by two different components: the sympathetic nervous system and the parasympathetic nervous system. [12]

Comparison of Sympathetic and Parasympathetic nervous systems The Autonomic Nervous System.jpg
Comparison of Sympathetic and Parasympathetic nervous systems

Sympathetic nervous system

The sympathetic nervous system originates in the spinal cord and its main function is to activate the arousal responses that occur during the fight-or-flight response. [13] The sympathetic nervous system transfers signals from the dorsal hypothalamus, which activates the heart, increases vascular resistance, and increases blood flow, especially to the muscle, heart, and brain tissues. [14] It activates the adrenal medulla, releasing catecholamines that amplify the sympathetic response. Additionally, this component of the autonomic nervous system utilizes and activates the release of norepinephrine by the adrenal glands in the reaction. [15]

Parasympathetic nervous system

The parasympathetic nervous system originates in the sacral spinal cord and medulla, physically surrounding the sympathetic origin, and works in concert with the sympathetic nervous system. It is known as the calming portion of the autonomic nervous system. [16] While the sympathetic nervous system is activated, the parasympathetic nervous system decreases its response. Efferent vagal fibers originating from the nucleus ambiguous fire in parallel to the respiratory system, decreasing the vagal cardiac parasympathetic tone. [17] After the fight or flight response, the parasympathetic system's main function is to activate the "rest and digest" response and return the body to homeostasis. This system utilizes and activates the release of the neurotransmitter acetylcholine. [18]

Reaction

The reaction begins in the amygdala, which triggers a neural response in the hypothalamus. The initial reaction is followed by activation of the pituitary gland and secretion of the hormone ACTH. [19] The adrenal gland is activated almost simultaneously, via the sympathetic nervous system, and releases the hormone epinephrine. The release of chemical messengers results in the production of the hormone cortisol, which increases blood pressure, blood sugar, and suppresses the immune system. [20]

The initial response and subsequent reactions are triggered in an effort to create a boost of energy. This boost of energy is activated by epinephrine binding to liver cells and the subsequent production of glucose. [21] Additionally, the circulation of cortisol functions to turn fatty acids into available energy, which prepares muscles throughout the body for response. [22]

Catecholamine hormones, such as adrenaline (epinephrine) or noradrenaline (norepinephrine), facilitate immediate physical reactions associated with a preparation for violent muscular action. [23]

Function of physiological changes

The physiological changes that occur during the fight or flight response are activated in order to give the body increased strength and speed in anticipation of fighting or running. Some of the specific physiological changes and their functions include: [24] [25] [26]

Emotional components

Emotion regulation

In the context of the fight or flight response, emotional regulation is used proactively to avoid threats of stress or to control the level of emotional arousal. Emotional socialization can develop someone's ability to successfully regulate their emotions. Faced with a perceived threat (in the context of a fight or flight situation) those raised with supportive parental behaviors are far more likely to easily self-regulate their emotions. [27] [28]

Emotional reactivity

During the reaction, the intensity of emotion that is brought on by the stimulus will also determine the nature and intensity of the behavioral response. [29] In a experiment conducted by Clayton, Lang, Leshner and Quick (2019), they viewed the responses of 49 participants to antitobacco messages. [30] Participants reacted in two orders of fashion after seeing the message with the individual smoker and their affects on those surrounding them. [31] The first reaction was participants who had higher defense mechanisms, who decided to ignore the messages, while the other participants who had lower defense mechanisms, ended up arguing and becoming frustrated after viewing the antitobacco messages. [32] [33] Individuals with higher levels of emotional reactivity (Such as an anxiety disorder) may be prone to anxiety and aggression, which illustrates the implications of appropriate emotional reaction in the fight or flight response. [34] [35]

Cognitive components

Content specificity

The specific components of cognitions in the fight or flight response seem to be largely negative. These negative cognitions may be characterised by: attention to negative stimuli, the perception of ambiguous situations as negative, and the recurrence of recalling negative words. [36] There also may be specific negative thoughts associated with emotions commonly seen in the reaction. [37]

Perception of control

Perceived control relates to an individual's thoughts about control over situations and events. [38] Perceived control should be differentiated from actual control because an individual's beliefs about their abilities may not reflect their actual abilities. Therefore, overestimation or underestimation of perceived control can lead to anxiety and aggression. [39]

Social information processing

The social information processing model proposes a variety of factors that determine behavior in the context of social situations and preexisting thoughts. [40] The attribution of hostility, especially in ambiguous situations, seems to be one of the most important cognitive factors associated with the fight or flight response because of its implications towards aggression. [41]

Other animals

Evolutionary perspective

An evolutionary psychology explanation is that early animals had to react to threatening stimuli quickly and did not have time to psychologically and physically prepare themselves. [42] The fight or flight response provided them with the mechanisms to rapidly respond to threats against survival. [43] [44]

Examples

A typical example of the stress response is a grazing zebra. If the zebra sees a lion closing in for the kill, the stress response is activated as a means to escape its predator. The escape requires intense muscular effort, supported by all of the body's systems. The sympathetic nervous system's activation provides for these needs. A similar example involving fight is of a cat about to be attacked by a dog. The cat shows accelerated heartbeat, piloerection (hair standing on end), and pupil dilation, all signs of sympathetic arousal. [23] Note that the zebra and cat still maintain homeostasis in all states.

In July 1992, Behavioral Ecology published experimental research conducted by biologist Lee A. Dugatkin where guppies were sorted into "bold", "ordinary", and "timid" groups based upon their reactions when confronted by a smallmouth bass (i.e. inspecting the predator, hiding, or swimming away) after which the guppies were left in a tank with the bass. After 60 hours, 40 percent of the timid guppies and 15 percent of the ordinary guppies survived while none of the bold guppies did. [45] [46]

Varieties of responses

Bison hunted by dogs Ruseckas-Stumbro medziokle.jpg
Bison hunted by dogs

Animals respond to threats in many complex ways. Rats, for instance, try to escape when threatened but will fight when cornered. Some animals stand perfectly still so that predators will not see them. Many animals freeze or play dead when touched in the hope that the predator will lose interest. [47]

Other animals have alternative self-protection methods. Some species of cold-blooded animals change color swiftly to camouflage themselves. [48] These responses are triggered by the sympathetic nervous system, but, in order to fit the model of fight or flight, the idea of flight must be broadened to include escaping capture either in a physical or sensory way. Thus, flight can be disappearing to another location or just disappearing in place, and fight and flight are often combined in a given situation. [49]

The fight or flight actions also have polarity – the individual can either fight against or flee from something that is threatening, such as a hungry lion, or fight for or fly towards something that is needed, such as the safety of the shore from a raging river.

A threat from another animal does not always result in immediate fight or flight. There may be a period of heightened awareness, during which each animal interprets behavioral signals from the other. Signs such as paling, piloerection, immobility, sounds, and body language communicate the status and intentions of each animal. There may be a sort of negotiation, after which fight or flight may ensue, but which might also result in playing, mating, or nothing at all. An example of this is kittens playing: each kitten shows the signs of sympathetic arousal, but they never inflict real damage.

In criminal law

Acute stress response is a common issue in self-defense criminal cases. Expert opinions are usually required if the defender's fault becomes the focus of the case. [50]

See also

Notes

  1. ↑ Cannon referred to "the necessities of fighting or flight." in the first edition of Bodily Changes in Pain, Hunger, Fear and Rage (1915), p. 211. Some references say he first described the response in 1914 in The American Journal of Physiology .

Related Research Articles

<span class="mw-page-title-main">Fear</span> Basic emotion induced by a perceived threat

Fear is an intensely unpleasant emotion in response to perceiving or recognizing a danger or threat. Fear causes psychological changes that may produce behavioral reactions such as mounting an aggressive response or fleeing the threat. Fear in human beings may occur in response to a certain stimulus occurring in the present, or in anticipation or expectation of a future threat perceived as a risk to oneself. The fear response arises from the perception of danger leading to confrontation with or escape from/avoiding the threat, which in extreme cases of fear can be a freeze response. The fear response is also implicated in a number of mental disorders, particularly anxiety disorders.

<span class="mw-page-title-main">Stress (biology)</span> Organisms response to a stressor such as an environmental condition or a stimulus

Stress, whether physiological, biological or psychological, is an organism's response to a stressor such as an environmental condition. When stressed by stimuli that alter an organism's environment, multiple systems respond across the body. In humans and most mammals, the autonomic nervous system and hypothalamic-pituitary-adrenal (HPA) axis are the two major systems that respond to stress. Two well-known hormones that humans produce during stressful situations are adrenaline and cortisol.

<span class="mw-page-title-main">Autonomic nervous system</span> Division of the nervous system supplying internal organs, smooth muscle and glands

The autonomic nervous system (ANS), sometimes called the visceral nervous system and formerly the vegetative nervous system, is a division of the nervous system that operates internal organs, smooth muscle and glands. The autonomic nervous system is a control system that acts largely unconsciously and regulates bodily functions, such as the heart rate, its force of contraction, digestion, respiratory rate, pupillary response, urination, and sexual arousal. The fight-or-flight response, also known as the acute stress response, is set into action by the autonomic nervous system.

<span class="mw-page-title-main">Hypothalamic–pituitary–adrenal axis</span> Set of physiological feedback interactions

The hypothalamic–pituitary–adrenal axis is a complex set of direct influences and feedback interactions among three components: the hypothalamus, the pituitary gland, and the adrenal glands. These organs and their interactions constitute the HPS axis.

<span class="mw-page-title-main">Sympathetic nervous system</span> Part of the autonomic nervous system which stimulates fight-or-flight responses

The sympathetic nervous system is one of the three divisions of the autonomic nervous system, the others being the parasympathetic nervous system and the enteric nervous system. The enteric nervous system is sometimes considered part of the autonomic nervous system, and sometimes considered an independent system.

Physiological psychology is a subdivision of behavioral neuroscience that studies the neural mechanisms of perception and behavior through direct manipulation of the brains of nonhuman animal subjects in controlled experiments. This field of psychology takes an empirical and practical approach when studying the brain and human behavior. Most scientists in this field believe that the mind is a phenomenon that stems from the nervous system. By studying and gaining knowledge about the mechanisms of the nervous system, physiological psychologists can uncover many truths about human behavior. Unlike other subdivisions within biological psychology, the main focus of psychological research is the development of theories that describe brain-behavior relationships.

<span class="mw-page-title-main">Arousal</span> State of being awoken

Arousal is the physiological and psychological state of being awoken or of sense organs stimulated to a point of perception. It involves activation of the ascending reticular activating system (ARAS) in the brain, which mediates wakefulness, the autonomic nervous system, and the endocrine system, leading to increased heart rate and blood pressure and a condition of sensory alertness, desire, mobility, and reactivity.

Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI) or psychoneuroendocrinoimmunology (PNEI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. It is a subfield of psychosomatic medicine. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.

<span class="mw-page-title-main">Baroreflex</span> Homeostatic mechanism in the body

The baroreflex or baroreceptor reflex is one of the body's homeostatic mechanisms that helps to maintain blood pressure at nearly constant levels. The baroreflex provides a rapid negative feedback loop in which an elevated blood pressure causes the heart rate to decrease. Decreased blood pressure decreases baroreflex activation and causes heart rate to increase and to restore blood pressure levels. Their function is to sense pressure changes by responding to change in the tension of the arterial wall. The baroreflex can begin to act in less than the duration of a cardiac cycle and thus baroreflex adjustments are key factors in dealing with postural hypotension, the tendency for blood pressure to decrease on standing due to gravity.

Acute stress reaction (ASR), also known as psychological shock, mental shock, or simply shock, and acute stress disorder (ASD), is a psychological response to a terrifying, traumatic, or surprising experience. Combat stress reaction (CSR) is a similar response to the trauma of war. The reactions may include but are not limited to intrusive or dissociative symptoms, and reactivity symptoms such as avoidance or arousal. It may be exhibited for days or weeks after the traumatic event. If the condition is not correctly addressed, it may develop into post-traumatic stress disorder (PTSD).

<span class="mw-page-title-main">Norepinephrine</span> Catecholamine hormone and neurotransmitter

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<span class="mw-page-title-main">Adrenaline</span> Hormone and medication

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<span class="mw-page-title-main">Effects of stress on memory</span> Overview of the effects of stress on memory

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<span class="mw-page-title-main">Sympathoadrenal system</span>

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References

  1. 1 2 Walker, Peter (2013). Complex PTSD: From Surviving to Thriving : a Guide and Map for Recovering from Childhood Trauma. An Azure Coyote Book. ISBN   978-1-4928-7184-2.
  2. ↑ Cannon, Walter (1932). Wisdom of the Body. United States: W.W. Norton & Company. ISBN   978-0-393-00205-8.
  3. 1 2 Walter Bradford Cannon (1915). Bodily changes in pain, hunger, fear, and rage. New York: Appleton-Century-Crofts. p. 211.
  4. ↑ Jansen, A; Nguyen, X; Karpitsky, V; Mettenleiter, M (27 October 1995). "Central Command Neurons of the Sympathetic Nervous System: Basis of the Fight-or-Flight Response". Science Magazine. 5236 (270): 644–6. Bibcode:1995Sci...270..644J. doi:10.1126/science.270.5236.644. PMID   7570024. S2CID   38807605.
  5. ↑ Walter Bradford Cannon (1915). Bodily Changes in Pain, Hunger, Fear and Rage: An Account of Recent Researches into the Function of Emotional Excitement. Appleton-Century-Crofts.
  6. ↑ "Adrenaline, Cortisol, Norepinephrine: The Three Major Stress Hormones, Explained". Huffington Post. April 19, 2014. Retrieved 16 August 2014.
  7. ↑ Kwon, Diana. "Fight or Flight May Be in Our Bones". Scientific American. Retrieved 2020-06-22.
  8. ↑ "Bone, not adrenaline, drives fight or flight response". phys.org. Retrieved 2020-06-22.
  9. ↑ Gozhenko, A; Gurkalova, I.P.; Zukow, W; Kwasnik, Z (2009). PATHOLOGY – Theory. Medical Student's Library. Radom. pp. 270–275.
  10. ↑ Donahue, J.J. (2020). "Fight-Flight-Freeze System". In Zeigler-Hill, V.; Shackelford, T.K. (eds.). Encyclopedia of Personality and Individual Differences. pp. 1590–1595. doi:10.1007/978-3-319-24612-3_751. ISBN   978-3-319-24610-9. S2CID   240856695.
  11. ↑ Bracha, H. Stefan (September 2004). "Freeze, Flight, Fight, Fright, Faint: Adaptationist Perspectives on the Acute Stress Response Spectrum" (PDF). CNS Spectrums. 9 (9): 679–685. doi:10.1017/S1092852900001954. PMID   15337864. S2CID   8430710 . Retrieved 31 May 2021.
  12. ↑ Schmidt, A; Thews, G (1989). "Autonomic Nervous System". In Janig, W (ed.). Human Physiology (2 ed.). New York, NY: Springer-Verlag. pp. 333–370.
  13. ↑ Myers, David G.; DeWall, C. Nathan (2021). Psychology (13 ed.). MacMillan Publishing. p. 422.
  14. ↑ Kozlowska, Kasia; Walker, Peter; McLean, Loyola; Carrive, Pascal (2015). "Fear and the Defense Cascade: Clinical Implications and Management". Harvard Review of Psychiatry . 23 (4): 263–287. doi:10.1097/HRP.0000000000000065. ISSN   1067-3229. PMC   4495877 . PMID   26062169.
  15. ↑ Chudler, Eric. "Neuroscience For Kids". University of Washington. Retrieved 19 April 2013.
  16. ↑ Myers, David G.; DeWall, C. Nathan (2021). Psychology (13 ed.). MacMillan Publishing. p. 422.
  17. ↑ Kozlowska, Kasia; Walker, Peter; McLean, Loyola; Carrive, Pascal (2015). "Fear and the Defense Cascade: Clinical Implications and Management". Harvard Review of Psychiatry . 23 (4): 263–287. doi:10.1097/HRP.0000000000000065. ISSN   1067-3229. PMC   4495877 . PMID   26062169.
  18. ↑ Chudler, Eric. "Neuroscience For Kids". University of Washington. Retrieved 19 April 2013.
  19. ↑ Margioris, Andrew; Tsatsanis, Christos (April 2011). "ACTH Action on the Adrenal". Endotext.org. Archived from the original on 6 March 2013. Retrieved 18 April 2013.
  20. ↑ Padgett, David; Glaser, R (August 2003). "How stress influences the immune response". Trends in Immunology. 24 (8): 444–448. CiteSeerX   10.1.1.467.1386 . doi:10.1016/S1471-4906(03)00173-X. PMID   12909458.
  21. ↑ King, Michael. "PATHWAYS: GLYCOGEN & GLUCOSE". Washington University in St. Louis.
  22. ↑ "HOW CELLS COMMUNICATE DURING THE FIGHT OR FLIGHT RESPONSE". University of Utah. Archived from the original on 8 August 2013. Retrieved 18 April 2013.
  23. 1 2 Henry Gleitman, Alan J. Fridlund and Daniel Reisberg (2004). Psychology (6 ed.). W. W. Norton & Company. ISBN   978-0-393-97767-7.
  24. ↑ Stress Management for Health Course. "The Fight Flight Response" . Retrieved 19 April 2013.
  25. ↑ Olpin, Michael. "The Science of Stress". Weber State University. Archived from the original on 2017-11-20. Retrieved 2013-04-25.
  26. ↑ Myers, David G.; DeWall, C. Nathan (2021). Psychology (13 ed.). MacMillan Publishing. p. 422.
  27. ↑ Cistler, Josh; Bunmi O. Olatunji; Matthew T. Feldner; John P. Forsyth (2010). "Emotion Regulation and the Anxiety Disorders: An Integrative Review". Journal of Psychopathology and Behavioral Assessment. 32 (1): 68–82. doi:10.1007/s10862-009-9161-1. PMC   2901125 . PMID   20622981.
  28. ↑ Gross, James (1998). "Sharpening the Focus: Emotion Regulation, Arousal, and Social Competence". Psychological Inquiry. 9 (4): 287–290. doi:10.1207/s15327965pli0904_8.
  29. ↑ Avero, Pedro; Calvo, M (1 July 1999). "Emotional reactivity to social-evaluative stress: genderdifferences in response systems concordance". Personality and Individual Differences. 27 (1): 155–170. doi:10.1016/S0191-8869(98)00229-3.
  30. ↑ Clayton, Russell B.; Lang, Annie; Leshner, Glenn; Quick, Brian L. (2019-07-04). "Who Fights, Who Flees? An Integration of the LC4MP and Psychological Reactance Theory". Media Psychology. 22 (4): 545–571. doi:10.1080/15213269.2018.1476157. ISSN   1521-3269.
  31. ↑ Sanders-Jackson, Ashley N.; Cappella, Joseph N.; Linebarger, Deborah L.; Piotrowski, Jessica Taylor; O'Keeffe, Moira; Strasser, Andrew A. (2011-04-01). "Visual Attention to Antismoking PSAs: Smoking Cues versus Other Attention-Grabbing Features". Human Communication Research. 37 (2): 275–292. doi:10.1111/j.1468-2958.2010.01402.x. ISSN   0360-3989. PMC   3489183 . PMID   23136462.
  32. ↑ Clayton, Russell B.; Leshner, Glenn; Tomko, Rachel L.; Trull, Timothy J.; Piasecki, Thomas M. (2017-03-04). "Who Fights, Who Flees? An Integration of the LC4MP and Psychological Reactance Theory". Media Psychology. 22 (3): 254–261. doi:10.1080/10810730.2016.1268222. ISSN   1081-0730. PMC   5451094 . PMID   28248620.
  33. ↑ Wong, Norman C. H.; Harrison, Kylie J.; Harvell, Lindsey A. (2015-09-24). "Reactance and Public Health Messages: The Unintended Dangers of Anti-tobacco PSAs". Studies in Media and Communication. 3 (2): 72–83. doi:10.11114/smc.v3i2.1022. ISSN   2325-808X.
  34. ↑ Carthy, T; Horesh N; Apter A; Edge MD; Gross JJ (May 2010). "Emotional reactivity and cognitive regulation in anxious children". Behaviour Research and Therapy. 48 (5): 384–393. doi:10.1016/j.brat.2009.12.013. PMID   20089246. S2CID   14382059.
  35. ↑ Valiente, C; Eisenberg N; Smith CL; Reiser M; Fabes RA; Losoya S; Guthrie IK; Murphy BC (December 2003). "The relations of effortful control and reactive control to children's externalising problems: A longitudinal assessment". Personality. 71 (6): 1171–1196. doi:10.1111/1467-6494.7106011. PMID   14633062.
  36. ↑ Reid, Sophie C.; Salmon, Karen; Peter F. Lovibond (October 2006). "Cognitive Biases in Childhood Anxiety, Depression, and Aggression: Are They Pervasive or Specific?". Cognitive Therapy and Research. 30 (5): 531–549. doi:10.1007/s10608-006-9077-y. S2CID   28911747.
  37. ↑ Beck, Aaron (1979). Cognitive Therapy and the Emotional Disorders. United States: Penguin Books.
  38. ↑ Weems, CF; Silverman, WK (April 2006). "An integrative model of control: implications for understanding emotion regulation and dysregulation in childhood anxiety". Journal of Affective Disorders. 91 (2): 113–124. doi:10.1016/j.jad.2006.01.009. PMID   16487599.
  39. ↑ Brendgen, M; Vitaro F; Turgeon L; Poulin F; Wanner B (June 2004). "Is there a dark side of positive illusions? Overestimation of social competence and subsequent adjustment in aggressive and nonaggressive children". Journal of Abnormal Child Psychology. 32 (3): 305–320. doi:10.1023/B:JACP.0000026144.08470.cd. PMID   15228179. S2CID   11239252.
  40. ↑ Crick, Nicki; Dodge, Kenneth (January 1994). "A review and reformulation of social information-processing mechanisms in children's social adjustment". Psychological Bulletin. 115 (1): 74–101. doi:10.1037/0033-2909.115.1.74.
  41. ↑ Dodge, Kenneth (March 1980). "Social cognition and children's aggressive behavior". Journal of Child Development. 51 (1): 162–170. doi:10.2307/1129603. JSTOR   1129603. PMID   7363732.
  42. ↑ Adamo, S. A. (2014-09-01). "The Effects of Stress Hormones on Immune Function May be Vital for the Adaptive Reconfiguration of the Immune System During Fight-or-Flight Behavior". Integrative and Comparative Biology. 54 (3): 419–426. doi: 10.1093/icb/icu005 . ISSN   1540-7063. PMID   24691569.
  43. ↑ Grohol, John. "What's the purpose of the fight or flight response?". Archived from the original on 23 March 2013. Retrieved 18 April 2013.
  44. ↑ Goldstein, David; Kopin, I (2007). "Evolution of concepts of stress". Stress. 10 (2): 109–20. doi: 10.1080/10253890701288935 . PMID   17514579. S2CID   25072963.
  45. ↑ Dugatkin, Lee Alan (1992). "Tendency to inspect predators predicts mortality risk in the guppy (Poecilia reticulata)". Behavioral Ecology . 3 (2). Oxford University Press: 125–127. doi:10.1093/beheco/3.2.124 . Retrieved September 9, 2020.
  46. ↑ Nesse, Randolph; Williams, George C. (1994). Why We Get Sick: The New Science of Darwinian Medicine. New York: Vintage Books. p. 213. ISBN   978-0-679-74674-4.
  47. ↑ Niermann, H.C.M.; Figner, F.; Roelofs, K. (January 24, 2017). "Individual differences in defensive stress-responses: the potential relevance for psychopathology". Current Opinion in Behavioral Sciences. 14: 94–101. doi:10.1016/j.cobeha.2017.01.002 – via Science Direct.
  48. ↑ Gill, A.C. (2004). Revision of the Indo-Pacific dottyback fish subfamily Pseudochrominae (Perciformes: Pseudochromidae). Smithiana Monographs. pp. 1–123.
  49. ↑ Singh, J; Aballay, A (April 8, 2019). "Microbial Colonization Activates an Immune Fight-and-Flight Response via Neuroendocrine Signaling". Developmental Cell. 49 (1): 89–99. doi: 10.1016/j.devcel.2019.02.001 . PMC   6456415 . PMID   30827896.
  50. ↑ Gawron, Tomáš (2023). Nutná obrana v právní praxi. Brno: Václav Klemm. p. 289. ISBN   978-80-87713-23-5.

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