RPP40

RPP40
Identifiers
Aliases	RPP40 , RNASEP1, bA428J1.3, ribonuclease P/MRP subunit p40
External IDs	OMIM: 606117 MGI: 1346084 HomoloGene: 4836 GeneCards: RPP40
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p25.1 Start 4,994,717 bp [1] End 5,004,063 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A3.3 Start 36,077,455 bp [2] End 36,090,342 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Left adrenal gland endothelial cell secondary oocyte middle temporal gyrus gastrocnemius muscle Brodmann area 23 monocyte human penis prefrontal cortex smooth muscle tissue Top expressed in morula proximal tubule yolk sac Paneth cell primitive streak sternocleidomastoid muscle spermatocyte maxillary prominence endocardial cushion temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribonuclease P activity hydrolase activity Cellular component nucleolus nucleus nucleolar ribonuclease P complex nucleoplasm Biological process RNA phosphodiester bond hydrolysis, endonucleolytic RNA phosphodiester bond hydrolysis tRNA processing tRNA 5'-leader removal Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10799 208366 Ensembl ENSG00000124787 ENSMUSG00000021418 UniProt O75818 Q8R1F9 RefSeq (mRNA) NM_001286132 NM_001286133 NM_006638 NM_145938 RefSeq (protein) NP_001273061 NP_001273062 NP_006629 NP_666050 Location (UCSC) Chr 6: 4.99 – 5 Mb Chr 13: 36.08 – 36.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribonuclease P protein subunit p40 is an enzyme that in humans is encoded by the RPP40 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000124787 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021418 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jarrous N, Eder PS, Guerrier-Takada C, Hoog C, Altman S (Jun 1998). "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P". RNA. 4 (4): 407–17. PMC   1369627 . PMID   9630247.
6. "Entrez Gene: RPP40 ribonuclease P 40kDa subunit".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC   407822 . PMID   15096576.