CGP-25454A

Last updated

CGP-25454A
CGP-25454A structure.png
Identifiers
  • 4-chloro-5-cyano-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C15H20ClN3O2
Molar mass 309.79 g·mol−1
3D model (JSmol)
  • CCN(CC)CCNC(=O)C1=C(C=C(C(=C1)C#N)Cl)OC
  • InChI=1S/C15H20ClN3O2/c1-4-19(5-2)7-6-18-15(20)12-8-11(10-17)13(16)9-14(12)21-3/h8-9H,4-7H2,1-3H3,(H,18,20)
  • Key:JEMKCYHUYUPGFN-UHFFFAOYSA-N

CGP-25454A is a drug which acts as an antagonist at presynaptic D2Sh autoreceptors on dopaminergic nerve terminals, producing stimulant effects at low doses in animal studies due to increased dopamine release, but sedative effects at higher doses due to loss of selectivity and antagonism of postsynaptic D2 receptors as well. [1]

See also

References

  1. ↑ Bischoff S, Baumann P, Krauss J, Maître L, Vassout A, Storni A, et al. (September 1994). "CGP 25454A, a novel and selective presynaptic dopamine autoreceptor antagonist". Naunyn-Schmiedeberg's Archives of Pharmacology. 350 (3): 230–238. doi:10.1007/BF00175027. PMID   7824038.
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